CGRP receptor antagonist olcegepant (BIBN4096BS) does not prevent glyceryl trinitrate-induced migraine

Tvedskov, Jesper Filtenborg; Tfelt‐Hansen, Peer; Petersen, KA; Jensen, L. L.; Olesen, Jes

doi:10.1177/0333102410363491

Cited by 50 publications

(47 citation statements)

References 27 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased plasma CGRP level was reported previously in GTN-induced migraine attacks, supporting the concept that NO may be involved in basic mechanisms in migraine attacks. On the other hand, although CGRP antagonists may be helpful in migraine attacks, they do not relieve GTN-induced migraine attacks (16). The most important effect of NO is the activation of the soluble guanylate cyclase.…”

Section: Discussionmentioning

confidence: 99%

Elevated plasma total nitrite levels may be related to migraine attacks

Neyal¹,

Geyik²,

Çekmen³

et al. 2014

Gaziantep Med J

View full text Add to dashboard Cite

Both vascular and neuronal mechanisms are the main foci of investigation in defining the pathophysiology of migraine attacks. This study was designed to evaluate the possible role of nitric oxide (NO) in migraine patients in the natural course of unprovoked attacks and attack-free periods. The mean plasma nitrite levels of 26 migraine patients during attacks and attack-free periods were compared within group and with those of 26 healthy controls. Plasma total nitrite levels were measured by Greiss reaction. Mean plasma total nitrite levels of migraine patients during attacks and attack-free periods and of controls were 36.5±7.5 μmol/l, 27.81±4.8 μmol/l and 25.19±4.1 μmol/l, respectively. These results demonstrated that total nitrite levels during attacks were significantly higher in migraineurs than both during attack-free periods and those of controls (P=0.001 and P=0.001, respectively). No significant difference was observed between migraineurs during attack-free periods and controls in this regard (P=0.534). Based on these results, we suggest that NO pathway may play a key role in the pathogenesis of migraine attacks.

show abstract

Section: Discussionmentioning

confidence: 99%

Elevated plasma total nitrite levels may be related to migraine attacks

Neyal¹,

Geyik²,

Çekmen³

et al. 2014

Gaziantep Med J

View full text Add to dashboard Cite

show abstract

“…Also, CGRP receptor antagonists do not prevent the headaches induced by nitroglycerin, thus confirming that these headaches are not CGRP dependent. 70 Other studies 71À73 have reported that vasodilation of the middle cerebral artery is induced with the nitroglycerin infusion, and its onset correlates with that of the immediate-type headache, but the vasodilatation abates prior to termination of the headache. Therefore, it is possible that MCA dilatation initiates immediate-type headaches, but it is not necessary for maintenance of these headaches.…”

Section: Nitric Oxidementioning

confidence: 96%

Newer Research and its Significance

Martin

2015

Headache and Migraine Biology and Management

View full text Add to dashboard Cite

“…NO-inhibitors are currently under research as possible new therapy target for migraine [65]. Although more studies are needed to draw categorical conclusions, the GTN migraine model may not be suitable to study the effects of CGRP receptor antagonists, since Tvedskov et al showed that GTN-induced migraine was not prevented by olcegepant [66]. A possible explanation could be that CGRP exerts its effect earlier than NO in the events leading to migraine after GTN infusion.…”

Section: Imaging Models In Humanmentioning

confidence: 99%

Discovery techniques for calcitonin gene-related peptide receptor antagonists for potential antimigraine therapies

Labruijere

Ibrahimi²,

Chan³

et al. 2013

Expert Opinion on Drug Discovery

View full text Add to dashboard Cite

Although triptans were a major breakthrough in migraine treatment, they are not effective for every patient and contraindicated in patients with cardiovascular disease. There is still a demand for other acute antimigraine acting drugs with CGRP receptor antagonists being the most promising candidates. CGRP plays a role in protection against ischemia, but CGRP receptor antagonists do not seem to affect this protection to a harmfull extent, when used incidentally as acute antimigraine treatment. In order for drug specificity to be increased, the site of action needs to be identified; this consequently may lead to a decrease in dosing with fewer side effects.

show abstract

CGRP receptor antagonist olcegepant (BIBN4096BS) does not prevent glyceryl trinitrate-induced migraine

Abstract: The present study indicates that NO does not induce migraine by liberating CGRP. The most likely explanation for our findings is that CGRP has its effect higher than NO in the cascade of events leading to MO attacks.

Cited by 50 publications

References 27 publications

Elevated plasma total nitrite levels may be related to migraine attacks

Elevated plasma total nitrite levels may be related to migraine attacks

Newer Research and its Significance

Discovery techniques for calcitonin gene-related peptide receptor antagonists for potential antimigraine therapies

Contact Info

Product

Resources

About