CGRP Inhibits Neurons of the Bed Nucleus of the Stria Terminalis: Implications for the Regulation of Fear and Anxiety

Gungor, Nur Zeynep; Paré, Denis

doi:10.1523/jneurosci.3473-13.2014

Cited by 33 publications

(27 citation statements)

References 46 publications

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“…In relation to anxiety-related behavior, previous study indicated that CGRP potentiates anxiety-related behavior. 30 If the DKT acts on the colorectum through CGRP release, DKT increases anxiety-related behavior, but the effects were not observed in our study. Also, one previous study indicated that CGRP did not affect anxiety-related behavior estimated by EPM.…”

Section: Cgrpcontrasting

confidence: 73%

Dai-Kenchu-To, a Herbal Medicine, Attenuates Colorectal Distention-induced Visceromotor Responses in Rats

Nakaya

Nagura

Hasegawa

et al. 2016

J Neurogastroenterol Motil

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Background/AimsDai-kenchu-to (DKT), a traditional Japanese herbal medicine, is known to increase gastrointestinal motility and improve ileal function. We tested our hypotheses that (1) pretreatment with DKT would block the colorectal distention-induced visceromotor response in rats, and (2) pretreatment with DKT would attenuate colorectal distention-induced adrenocorticotropic hormone (ACTH) release and anxiety-related behavior. MethodsRats were pretreated with vehicle or DKT (300 mg/kg/5 mL, per os). Visceromotor responses were analyzed using electromyography in response to colorectal distention (10,20, 40, 60, and 80 mmHg for 20 seconds at 3-minutes intervals). Anxiety-related behavior was measured during exposure to an elevated-plus maze after colorectal distention. Plasma ACTH and serum corticosterone levels were measured after exposure to the elevated-plus maze. ResultsColorectal distention produced robust contractions of the abdominal musculature, graded according to stimulus intensity, in vehicletreated rats. At 40, 60, and 80 mmHg of colorectal distention, the visceromotor responses of DKT-treated rats was significantly lower than that of vehicle-treated rats. At 80 mmHg, the amplitude was suppressed to approximately one-third in DKT-treated rats, compared with that in vehicle-treated rats. Smooth muscle compliance and the velocity of accommodation to 60 mmHg of stretching did not significantly differ between the vehicle-treated and DKT-treated rats. Similarly, the DKT did not influence colorectal distentioninduced ACTH release, corticosterone levels, or anxiety-related behavior in rats. ConclusionsOur results suggest that DKT attenuates the colorectal distention-induced visceromotor responses, without increasing smooth muscle compliance, ACTH release or anxiety-related behavior in rats.

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Section: Cgrpcontrasting

confidence: 73%

Dai-Kenchu-To, a Herbal Medicine, Attenuates Colorectal Distention-induced Visceromotor Responses in Rats

Nakaya

Nagura

Hasegawa

et al. 2016

J Neurogastroenterol Motil

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“…Vertebrate CGRP has been implicated in controlling anxiety [65, 66] and stress response [67, 68]. While not previously addressed experimentally, the intimate relationship between stress, anxiety, and sleep [5] suggest that CGRP might regulate sleep.…”

Section: Discussionmentioning

confidence: 99%

Calcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila

et al. 2014

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Summary Background Imbalances in amount and timing of sleep are harmful to physical and mental health. Therefore, the study of the underlying mechanisms is of great biological importance. Proper timing and amount of sleep is regulated by both the circadian clock and homeostatic sleep drive. However, very little is known about the cellular and molecular mechanisms by which the circadian clock regulates sleep. In this study we describe a novel role for DIURETIC HORMONE 31 (DH31), the fly homologue of the vertebrate neuropeptide CALCITONIN GENE RELATED PEPTIDE (CGRP), as a circadian wake-promoting signal that awakens the fly in anticipation of dawn. Results Analysis of loss-of-function and gain-of-function Drosophila mutants demonstrates that DH31 suppresses sleep late at night. DH31 is expressed by a subset of dorsal circadian clock neurons that also express the receptor for the circadian neuropeptide PIGMENT DISPERSING FACTOR (PDF). PDF secreted by the ventral pacemaker subset of circadian clock neurons acts on PDF receptors in the DH31-expressing dorsal clock neurons to increase DH31 secretion before dawn. Activation of PDFR in DH31 positive DN1 specifically affects sleep and has no effect on circadian rhythms, thus constituting a dedicated locus for circadian regulation of sleep. Conclusions We identified a novel signaling molecule (DH31) as part of a neuropeptide relay mechanism for circadian control of sleep. Our results indicate that outputs of the clock controlling sleep and locomotor rhythms are mediated via distinct neuronal/cellular channels.

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“…Based on findings from a recent study [95•], CGRP is likely to contribute to migraine pathology by facilitating anxiety-like states mediated via projections of the bed nucleus of the stria terminalis to autonomic and neuroendocrine regulatory structures of the brain. Injection of CGRP was shown to potentiate anxiety-like behaviors and increase neural activity in bed nucleus of the stria terminalis targets.…”

Section: Migraine Risk Factors and Cgrp: Role Of Stress Anxiety Andmentioning

confidence: 99%

Diverse Physiological Roles of Calcitonin Gene-Related Peptide in Migraine Pathology: Modulation of Neuronal-Glial-Immune Cells to Promote Peripheral and Central Sensitization

Durham

2016

Curr Pain Headache Rep

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The neuropeptide calcitonin gene-related peptide (CGRP) is implicated in the underlying pathology of migraine by promoting the development of a sensitized state of primary and secondary nociceptive neurons. The ability of CGRP to initiate and maintain peripheral and central sensitization is mediated by modulation of neuronal, glial, and immune cells in the trigeminal nociceptive signaling pathway. There is accumulating evidence to support a key role of CGRP in promoting cross excitation within the trigeminal ganglion that may help to explain the high co-morbidity of migraine with rhinosinusitis and temporomandibular joint disorder. In addition, there is emerging evidence that CGRP facilitates and sustains a hyperresponsive neuronal state in migraineurs mediated by reported risk factors such as stress and anxiety. In this review, the significant role of CGRP as a modulator of the trigeminal system will be discussed to provide a better understanding of the underlying pathology associated with the migraine phenotype.

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CGRP Inhibits Neurons of the Bed Nucleus of the Stria Terminalis: Implications for the Regulation of Fear and Anxiety

Cited by 33 publications

References 46 publications

Dai-Kenchu-To, a Herbal Medicine, Attenuates Colorectal Distention-induced Visceromotor Responses in Rats

Dai-Kenchu-To, a Herbal Medicine, Attenuates Colorectal Distention-induced Visceromotor Responses in Rats

Calcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila

Diverse Physiological Roles of Calcitonin Gene-Related Peptide in Migraine Pathology: Modulation of Neuronal-Glial-Immune Cells to Promote Peripheral and Central Sensitization

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