CGRP

King, R; Brain, Susan D.

doi:10.1016/b978-0-12-385095-9.00189-5

Cited by 4 publications

(8 citation statements)

References 35 publications

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“…Patients receiving CGRP intravenously at room temperature have a proper digital vasoconstriction. At 5°C the effect of CGRP administration is poor [3].…”

Section: Prace Oryginalnementioning

confidence: 98%

“…Eight patients had higher CGRP plasma levels in the delayed headache-free period. However, a small number of patients were enrolled in this study, and the CGRP plasma levels in the cranial and peripheral circulation may be undetectable [3]. Eccentric muscle contraction and rapid stretching produces scattered myofibres and intramuscular plasma extravasation [25].…”

Section: Prace Oryginalnementioning

confidence: 99%

“…thyroid tissue of aging rats [3]. A human form of CGRP was first isolated from medullary thyroid carcinomas.…”

Section:  Prace Oryginalnementioning

confidence: 99%

“…A human form of CGRP was first isolated from medullary thyroid carcinomas. Two isoforms of CGRP have been discovered (α CGRP, ß CGRP), but the ß CGRP is poorly understood [3]. Human α CGRP is primarily located in unmyelinated, small-diameter sensory C fibres, commonly found in close contact with the vasculature, especially the arterial side.…”

Section:  Prace Oryginalnementioning

confidence: 99%

“…Vasodilator activity of CGRP was first described by Brain in 1985, who characterised it as the most potent microvascular vasodilator [4]. An intradermal injection of CGRP was sufficient to induce erythema and increase blood flow in that area [3]. Small doses injected into human skin produce an erythema that lasts for 5-6 hours [4].…”

Section:  Prace Oryginalnementioning

confidence: 99%

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Venopunkcja żyły odłokciowej jako alternatywne podejście dla oceny stężenia CGRP w osoczu krwi u pacjentów z dysfunkcją układu ruchowego narządu żucia

Nitecka-Buchta¹,

Marek

Kapustecka³

et al. 2017

Endokrynologia Polska

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“…Patients receiving CGRP intravenously at room temperature have a proper digital vasoconstriction. At 5°C the effect of CGRP administration is poor [3].…”

Section: Prace Oryginalnementioning

confidence: 98%

Section: Prace Oryginalnementioning

confidence: 99%

“…thyroid tissue of aging rats [3]. A human form of CGRP was first isolated from medullary thyroid carcinomas.…”

Section:  Prace Oryginalnementioning

confidence: 99%

Section:  Prace Oryginalnementioning

confidence: 99%

Section:  Prace Oryginalnementioning

confidence: 99%

See 3 more Smart Citations

Venopunkcja żyły odłokciowej jako alternatywne podejście dla oceny stężenia CGRP w osoczu krwi u pacjentów z dysfunkcją układu ruchowego narządu żucia

Nitecka-Buchta¹,

Marek

Kapustecka³

et al. 2017

Endokrynologia Polska

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Natriuretic Peptides as the Basis of Peptide Drug Discovery for Cardiovascular Diseases

Lerner

Hanout

Ben-Uliel

et al. 2020

CTMC

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: : Cardiovascular diseases (CVDs) are the leading global cause of death, accounting for more than 17.6 million deaths per year in 2016, a number that is expected to grow to more than 23.6 million by 2030. While many technologies are currently under investigation to improve the therapeutic outcome of CVD complications, only few medications have been approved. Therefore, new approaches to treat CVD are urgently required. Peptides regulate numerous physiological processes, mainly by binding to specific receptors and inducing a series of signals, neurotransmissions or the release of growth factors. Importantly, peptides have also been shown to play an important role in the circulatory system both in physiological and pathological conditions. Peptides, such as angiotensin II, endothelin, urotensin-II, urocortins, adrenomedullin and natriuretic peptides have been implicated in the control of vascular tone and blood pressure as well as in CVDs such as congestive heart failure, atherosclerosis, coronary artery disease, and pulmonary and systemic hypertension. Hence it is not surprising that peptides are becoming important therapeutic leads in CVDs. This article will review the current knowledge about peptides and their role in the circulatory system, focusing on the physiological roles of natriuretic peptides in the cardiovascular system and their implications in CVDs.

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Nociceptor–Macrophage Interactions in Apical Periodontitis: How Biomolecules Link Inflammation with Pain

Menon,

Kishen

2023

Biomolecules

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Periradicular tissues have a rich supply of peripheral afferent neurons, also known as nociceptive neurons, originating from the trigeminal nerve. While their primary function is to relay pain signals to the brain, these are known to be involved in modulating innate and adaptive immunity by initiating neurogenic inflammation (NI). Studies have investigated neuroanatomy and measured the levels of biomolecules such as cytokines and neuropeptides in human saliva, gingival crevicular fluid, or blood/serum samples in apical periodontitis (AP) to validate the possible role of trigeminal nociceptors in inflammation and tissue regeneration. However, the contributions of nociceptors and the mechanisms involved in the neuro-immune interactions in AP are not fully understood. This narrative review addresses the complex biomolecular interactions of trigeminal nociceptors with macrophages, the effector cells of the innate immune system, in the clinical manifestations of AP.

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CGRP

Cited by 4 publications

References 35 publications

Venopunkcja żyły odłokciowej jako alternatywne podejście dla oceny stężenia CGRP w osoczu krwi u pacjentów z dysfunkcją układu ruchowego narządu żucia

Venopunkcja żyły odłokciowej jako alternatywne podejście dla oceny stężenia CGRP w osoczu krwi u pacjentów z dysfunkcją układu ruchowego narządu żucia

Natriuretic Peptides as the Basis of Peptide Drug Discovery for Cardiovascular Diseases

Nociceptor–Macrophage Interactions in Apical Periodontitis: How Biomolecules Link Inflammation with Pain

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