cGMP signaling pathway that modulates NF-κB activation in innate immune responses

Kanoh, Hirotaka; Iwashita, Shinzo; Kuraishi, Takayuki; Goto, Ayumu; Fuse, Naoyuki; Ueno, Hisanori; Nimura, Mariko; Oyama, Tomohito; Tang, Chang; Watanabe, Ryoji; Hori, Ariyuki; Momiuchi, Yoshiki; Ishikawa, Hiroki; Suzuki, Hiroaki; Nabe, Kumiko; Takagaki, Takeshi; Fukuzaki, Masataka; Tong, Lili; Yamada, So; Oshima, Yoshiteru; Aigaki, Toshiro; Dow, Julian A. T.; Davies, Shireen-A.; Kurata, Shoichiro

doi:10.1016/j.isci.2021.103473

Cited by 10 publications

(3 citation statements)

References 65 publications

(86 reference statements)

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“…However, in the current study we couldn't observe the two lipogenic enzymes as nsP3 interacting partners in THP1 derived macrophages. In our study, cGMP-PKG signaling pathways were found to be modulated which directly regulate the NF Kappa beta pathway, facilitating the activation of innate immune responses (33). Surfeit 4, another interacting partner, is a well-known protein in HCV infection.…”

Section: Discussionmentioning

confidence: 63%

Decoding chikungunya virus non-structural protein 3 interacting partners in THP-1 derived infected macrophages through proteomic profiling

Srivastava,

Mishra,

Chaudhary

et al. 2024

Front. Virol.

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IntroductionChikungunya virus (CHIKV), an alphavirus transmitted by mosquitoes, has instigated several epidemics in recent years, sparking intensive efforts to understand its biology. Despite progress, the understanding of CHIKV’s molecular interactions with host cell constituents, especially in susceptible cells such as macrophages remains limited.MethodsWe used a mass spectrometry platform to characterize the interactions between CHIKV-nsP3, a viral nonstructural protein, and proteins in human THP-1 macrophage cells.Results and DiscussionOur findings revealed 196 high-confidence interactions primarily involving nsP3. Further, the sub-cellular localization, and pathways these interacting proteins might be involved in were deduced using computational methods. The interacting partners were further incorporated into a comprehensive host-virus interaction network derived from extensive literature on alphavirus-host interactions. Collectively, this study offers the first interaction map between CHIKV nsP3 protein and THP-1 cells, illuminating new probable roles of host cell proteins in CHIKV’s replication cycle.

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Section: Discussionmentioning

confidence: 63%

Decoding chikungunya virus non-structural protein 3 interacting partners in THP-1 derived infected macrophages through proteomic profiling

Srivastava,

Mishra,

Chaudhary

et al. 2024

Front. Virol.

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“…STAT3 is a transcription factor for fibrotic genes such as collagen I and α-SMA [ 42 , 54 ]. cGMP is generated as a result of relaxin activity, and its signaling pathway may inhibit NF- κB activation in innate immunity [ 95 ]. cGMP is cyclic guanosine monophosphate, ERK1/2 is extracellular-signal regulated kinase 1/2, NOS is nitric oxide synthase, RXFP1 is relaxin family peptide receptor 1, and TGFβ is transforming growth factor-β.…”

Section: Discussionmentioning

confidence: 99%

Relaxin Affects Airway Remodeling Genes Expression through Various Signal Pathways Connected with Transcription Factors

Wieczfińska

Pawliczak

2022

IJMS

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Fibrosis is one of the parameters of lung tissue remodeling in asthma. Relaxin has emerged as a natural suppressor of fibrosis, showing efficacy in the prevention of a multiple models of fibrosis. Therefore, the aim of this study was to analyze the aptitudes of relaxin, in the context of its immunomodulatory properties, in the development of airway remodeling. WI-38 and HFL1 fibroblasts, as well as epithelial cells (NHBE), were incubated with relaxin. Additionally, remodeling conditions were induced with two serotypes of rhinovirus (HRV). The expression of the genes contributing to airway remodeling were determined. Moreover, NF-κB, c-Myc, and STAT3 were knocked down to analyze the pathways involved in airway remodeling. Relaxin decreased the mRNA expression of collagen I and TGF-β and increased the expression of MMP-9 (p < 0.05). Relaxin also decreased HRV-induced expression of collagen I and α-SMA (p < 0.05). Moreover, all the analyzed transcription factors—NF-κB, c-Myc, and STAT3—have shown its influence on the pathways connected with relaxin action. Though relaxin requires further study, our results suggest that this natural compound offers great potential for inhibition of the development, or even reversing, of factors related to airway remodeling. The presented contribution of the investigated transcription factors in this process additionally increases its potential possibilities through a variety of its activity pathways.

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“…In D. melanogaster , the cGMP-dependent signaling pathway regulates NF-κB in the immune system. Engineered NPs exhibit a heightened ability to target DCs and promote the development of a tolerogenic phenotype during the induction of immune tolerance [ 97 , 98 ]. Table 5 summarizes the diverse mechanisms and pathways that offer promising targets for the therapeutic regulation and intervention of the immune system.…”

Section: Immunomodulatory Strategies In Drug Deliverymentioning

confidence: 99%

Nanomaterial-Driven Precision Immunomodulation: A New Paradigm in Therapeutic Interventions

Aljabali,

Obeid,

Gammoh

et al. 2024

Cancers

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Immunotherapy is a rapidly advancing field of research in the treatment of conditions such as cancer and autoimmunity. Nanomaterials can be designed for immune system manipulation, with precise targeted delivery and improved immunomodulatory efficacy. Here, we elaborate on various strategies using nanomaterials, including liposomes, polymers, and inorganic NPs, and discuss their detailed design intricacies, mechanisms, and applications, including the current regulatory issues. This type of nanomaterial design for targeting specific immune cells or tissues and controlling release kinetics could push current technological frontiers and provide new and innovative solutions for immune-related disorders and diseases without off-target effects. These materials enable targeted interactions with immune cells, thereby enhancing the effectiveness of checkpoint inhibitors, cancer vaccines, and adoptive cell therapies. Moreover, they allow for fine-tuning of immune responses while minimizing side effects. At the intersection of nanotechnology and immunology, nanomaterial-based platforms have immense potential to revolutionize patient-centered immunotherapy and reshape disease management. By prioritizing safety, customization, and compliance with regulatory standards, these systems can make significant contributions to precision medicine, thereby significantly impacting the healthcare landscape.

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cGMP signaling pathway that modulates NF-κB activation in innate immune responses

Cited by 10 publications

References 65 publications

Decoding chikungunya virus non-structural protein 3 interacting partners in THP-1 derived infected macrophages through proteomic profiling

Decoding chikungunya virus non-structural protein 3 interacting partners in THP-1 derived infected macrophages through proteomic profiling

Relaxin Affects Airway Remodeling Genes Expression through Various Signal Pathways Connected with Transcription Factors

Nanomaterial-Driven Precision Immunomodulation: A New Paradigm in Therapeutic Interventions

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