cGAS-STING pathway in pathogenesis and treatment of osteoarthritis and rheumatoid arthritis
XiCheng Yang,
LiLi Zhao,
YinQuan Pang
Abstract:Osteoarthritis (OA) and Rheumatoid Arthritis (RA) are significant health concerns with notable prevalence and economic impact. RA, affecting 0.5% to 1.0% of the global population, leads to chronic joint damage and comorbidities. OA, primarily afflicting the elderly, results in joint degradation and severe pain. Both conditions incur substantial healthcare expenses and productivity losses. The cGAS-STING pathway, consisting of cyclic GMP–AMP synthase (cGAS) and stimulator of interferon genes (STING), is a cruci… Show more
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