cGAS regulates the DNA damage response to maintain proliferative signaling in gastric cancer cells

Liu, Bin; LIU, HAIPENG; Ren, Feifei; LIU, HANGFAN; BUKHARI, IHTISHAM; FU, YUMING; WU, WANQING; ZHAO, MINGHAI; ZHU, SHAOGONG; Hui, Ming; LI, FAZHAN; ZHENG, MICHAEL B.; Tang, Youcai; Zheng, Peng‐Yuan; Mi, Yang

doi:10.32604/or.2022.03529

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…cGAS expression and MRN complex activation were directly correlated, suggesting that cGAS could be directly involved in the formation of the MRN complex. This theory is supported by the finding that cGAS and MRE11 were detected in the immunoprecipitated lysates of AGS cell lines ( Liu et al, 2021 ). The authors concluded that cGAS overexpression leads to the activation of the MRN complex, thereby promoting genomic instability in gastric cancer cells and leading to tumor progression.…”

Section: Cgas Signaling Pathways In Gi Malignanciesmentioning

confidence: 73%

“…Increased expression of cGAS has been found in gastric cancer tissue in comparison to normal gastric mucosa utilizing the TCGA database. There is a stepwise increase in cGAS expression during the progression from normal gastric mucosa to T4 disease ( Liu et al, 2021 ). Using human AGS and MKN45 gastric cancer cell lines with siRNA knocked-down cGAS, it was demonstrated that cGAS-deficient gastric cells have reduced cell viability compared to non-gastric cancer cells with cGAS knocked down.…”

Section: Cgas Signaling Pathways In Gi Malignanciesmentioning

confidence: 99%

“…The authors concluded that cGAS overexpression leads to the activation of the MRN complex, thereby promoting genomic instability in gastric cancer cells and leading to tumor progression. Thus, downregulation of the MRN complex leading to the deactivation of cell cycle checkpoints could be a potential target for therapy ( Liu et al, 2021 ).…”

Section: Cgas Signaling Pathways In Gi Malignanciesmentioning

confidence: 99%

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The role of cGAS in epithelial dysregulation in inflammatory bowel disease and gastrointestinal malignancies

Ramos,

Bizri,

Novak

et al. 2024

Front. Pharmacol.

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The gastrointestinal tract is lined by an epithelial monolayer responsible for selective permeability and absorption, as well as protection against harmful luminal contents. Recognition of foreign or aberrant DNA within these epithelial cells is, in part, regulated by pattern recognition receptors such as cyclic GMP-AMP synthase (cGAS). cGAS binds double-stranded DNA from exogenous and endogenous sources, resulting in the activation of stimulator of interferon genes (STING) and a type 1 interferon response. cGAS is also implicated in non-canonical pathways involving the suppression of DNA repair and the upregulation of autophagy via interactions with PARP1 and Beclin-1, respectively. The importance of cGAS activation in the development and progression of inflammatory bowel disease and gastrointestinal cancers has been and continues to be explored. This review delves into the intricacies of the complex role of cGAS in intestinal epithelial inflammation and gastrointestinal malignancies, as well as recent therapeutic advances targeting cGAS pathways.

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Section: Cgas Signaling Pathways In Gi Malignanciesmentioning

confidence: 73%

Section: Cgas Signaling Pathways In Gi Malignanciesmentioning

confidence: 99%

Section: Cgas Signaling Pathways In Gi Malignanciesmentioning

confidence: 99%

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