CFTR anion channel regulation by phosphorylation of focal adhesion kinase at tyrosine 407 in osmosensing mitochondria‐rich ion transporting cells of killifish (Fundulus heteroclitus)
Abstract:Focal adhesion kinase (FAK) is a tyrosine kinase with multiple Y sites and an ezrin/radixin/moesin binding site. Antibodies to the phosphorylated form of FAK at Y407 and Y587 are colocalized with the Cl− channel CFTR in the apical membrane of mitochondria‐rich (MR) cells of seawater‐acclimated euryhaline killifish opercular epithelium. Hypotonic treatment (80%, 224 mOsm/kg) causes rapid, reversible cell swelling (observed via confocal microscopy of living cells in situ), inhibition of Cl− secretion and dephosp… Show more
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