CFL1-dependent dynamicity of surface ectoderm filopodia-like protrusions enhances neurulation zippering speed in mice
Abigail R Marshall,
Andrea Krstevski,
Henry Croswell
et al.
Abstract:Progression of caudally-directed embryonic neural tube closure must exceed that of body axis elongation, otherwise closure is incomplete and neural tube defects arise. Genetic deletion and pharmacological antagonism studies establish the critical role of actomyosin regulation in this closure process in mice, but many models of impaired F-actin regulation are limited by early embryonic lethality, which precludes mechanistic insightin vivo. Here, we test the physiological functions of the F-actin severing protei… Show more
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