In this work, a coarse‐grained Dense Discrete Phase Model (DDPM) coupled with the Energy‐Minimization Multi‐Scale (EMMS) drag, was used to simulate the hydrodynamics of a 3D semi‐industrial scale Circulating Fluidized Bed (CFB) with Geldart A particles. The effect of particle numbers in a parcel, an important parameter in a coarse‐grained approach, was investigated. It was found that when parcel diameter falls into the size range of clusters, simulation results are insensitive to particle number in a parcel and generally agree with the experimental data. Further, a comparison between DDPM and Eulerian Two‐Fluid Modelling (TFM) approaches was investigated, both coupled with EMMS and conventional homogenous drag. The simulation results suggested that the effect of meso‐scale structures on drag force needs to be considered in both modelling approaches.