CFD–PBE Model and Simulation of Continuous Antisolvent Crystallization in an Impinging Jet Crystallizer with a Multiorifice at Different Positions

Chen, Mingyu; Wang, Jingkang; Li, Shuyu; Wang, Ting; Huang, Xin; Hao, Hongxun

doi:10.1021/acs.iecr.1c01610

Cited by 11 publications

(4 citation statements)

References 32 publications

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“…Additionally, an industrial large‐scale pharmaceutical production should consider the hydrodynamics of the crystallization process as another important factor. CFD simulations can be used as a powerful tool to optimize the reactor design, flow rate, agitation speed, and addition rate of species [106–111]. Both aspects mentioned require precise determination of the crystal's size, shape, polymorph, or other chemical/physical properties of the solution and species, which necessitate accurate in‐line measurement tools.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Haghighizadeh,

Mahdavi,

Rajabi

2024

Chem Eng & Technol

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Continuous crystallization of pharmaceuticals has been in the center of attention during the past two decades, with a more focus on the large‐scale production of active pharmaceutical ingredients. The increasing demand for pharmaceuticals requires high‐throughput production of drug crystals with different solubilities, stabilities, shapes, habits, polymorphs, and size distributions. With numerous advantages including low cost, ease of scale‐up, and superior control over polymorph and size distribution of drug crystals, antisolvent crystallization is one of the most promising crystallization methods recently attempted. However, it fails to deliver the required characteristic where the crystal systems tend to grow and for the preparation of metastable polymorphs. This review focuses on the most recent efforts to tackle these drawbacks by coupling antisolvent crystallization with cooling, supercritical‐assisted, microfluidics‐assisted, and membrane‐assisted crystallization. This systematic review aims to provide a concise summary of each coupled antisolvent technique and their positive and negative aspects. This review can be used as a guideline for pharmacist, biologists, and chemists, who are interested in the crystal engineering of pharmaceuticals to pave the way for further developments in this field.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Haghighizadeh,

Mahdavi,

Rajabi

2024

Chem Eng & Technol

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“…Wu et al found that the antisolvent crystallization was independent of mixing with the multiorifice-impinging transverse jet crystallizer due to its high mixing efficiency. Chen et al found that the mixing and crystal size in the multiorifice-impinging jet crystallizer can still be improved by a higher jet-to-cross-flow velocity ratio of 6 and a moderate feed point number of 3. Valeh-e-Sheyda and Mir found that the crystal size and CSD width decreased with the large confluence angle of 135° in the microchannel reactors.…”

Section: Phase Change For Separation and Purificationmentioning

confidence: 99%

Recent Advances in CFD Simulations of Multiphase Flow Processes with Phase Change

Zhu

Zhang

et al. 2023

Ind. Eng. Chem. Res.

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Phase change is a phenomenon that has been extensively utilized in chemical engineering, energy, electronics, vehicle, and space exploration. From both the science and engineering perspectives, gaining a profound understanding of the intricacies of multiphase flow processes accompanied by heat and mass transfer due to phase change is of fundamental importance. Indeed, the computational fluid dynamics (CFD) has been increasingly applied as an effective tool to give an in-depth and efficient analysis of the phase change processes, thereby enhancing our understanding and capacity to control and optimize the phase change effects in these processes. This paper seeks to provide a comprehensive review of the utilization of CFD methodologies in the simulations of phase change flows across various applications, including temperature management, drying, separation and purification, and others. First, the CFD models at various scales that are developed to elucidate the phase change processes are summarized. Second, the noteworthy advances in the recent CFD simulation work on various phase change processes are presented, respectively. Finally, the challenges and potential prospects to facilitate the application of the phase change flow are discussed. The current review aims to offer insightful guidance for the CFD modeling of phase change processes in numerous engineering application scenarios.

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“…Research on crystallizer modeling using computational fluid dynamics (CFD) simulation is ongoing. The population balance equation (PBE) proposed by Hulburt and Katz is widely used to predict the crystal size distribution (CSD). − Coupled CFD–PBE research is being conducted actively for various crystallizer designs and operating conditions to improve the crystallizer performance. ,− However, such studies have mostly investigated nonslug tubular crystallizers. Tubular crystallizers, such as the Archimedes tube crystallizer and slug-flow crystallizer, , have also been subjected to many numerical studies.…”

Section: Introductionmentioning

confidence: 99%

Computational Fluid Dynamics Simulation for Controllable Residence Time Distribution in a Slug Flow Crystallizer

Lee,

Mou,

Kim

et al. 2024

Crystal Growth & Design

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Recently, slug-flow crystallizers have been proposed for controlling the product quality and generating uniform crystals. However, there is still a lack of understanding of the residence time distribution (RTD) of slug flow with liquid films. Herein, we developed a computational fluid dynamics model to simulate a gas−liquid slug flow with liquid film phenomenon to obtain the RTD. The proposed model was validated by comparing the resulting slug geometries and RTDs with experiments using various solvents. The results highlighted the appropriate solvent properties and operating conditions required to generate a narrow RTD. Unfavorable conditions yielded wide RTDs with multiple peaks due to liquid-film diffusion. Furthermore, the higher the flow rate, the lower the RTD variance, but the resulting slug formation was unstable and broken. In summary, analysis using the proposed methodology led to controllable slug formation with a sharp RTD, which facilitated the manufacture of high-quality uniform crystals.

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CFD–PBE Model and Simulation of Continuous Antisolvent Crystallization in an Impinging Jet Crystallizer with a Multiorifice at Different Positions

Cited by 11 publications

References 32 publications

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Recent Advances in CFD Simulations of Multiphase Flow Processes with Phase Change

Computational Fluid Dynamics Simulation for Controllable Residence Time Distribution in a Slug Flow Crystallizer

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