Open cell foams are considered promising catalytic substrates providing high surface area and a tortuous structure resulting in enhanced mass transfer characteristics. CFD analysis, recently, has focused in pointing structures with favourable reactivity-flow resistance characteristics. In order to reduce the geometrical complexity and computational efforts, foams have been modelled as regular (polyhedric) open cell structures. In this study a comprehensive comparison of real foams with equivalent Kelvin cell lattices is performed in CFD. Therefore 4 typical foams (two ceramic and two metallic) have been chosen. Geometric properties have been accessed with Micro-Tomography scans. Randomised Kelvin cell lattices have been generated matching porosity and specific surface area of the scanned real foams. Geometric, momentum and mass transfer characteristics of real foams and Kelvin cell lattices are analysed with CFD. Kelvin cell lattices showed similar behaviour in respect to their real foam equivalents, had though clearly better reactivity-pressure drop trade-offs. Based on the results presented best performances as a catalyst can be expected by 3D printed, additive manufactured, high porosity polyhedric structures