CFD Challenge: Predicting Patient-Specific Hemodynamics at Rest and Stress through an Aortic Coarctation

Abstract

Abstract. The here presented work is part of a CFD challenge investigating the potential for computational fluid dynamics (CFD) simulations to predicted pressures and flows in an aortic coarctation during stress when conditions for the rest case are known. In our approach, we choose to couple a three element Windkessel model to the outlet boundary conditions. Good reproducibility of flow and pressures for the rest case were achieved. In the stress case, where only the inflow boundary condition was changed, baseline pressure was too high, indicating that the total resistance in the Windkessel models may need to be reduced. This would correspond to dilating the blood vessels as might be the result of a pharmacological stress test. Future work is needed to develop an optimization strategy to tune the Windkessel data for matching the clinical results.

Thermal-electrical analogy and inertia for thermal performance of building envelops

“…The Windkessel model is validated by experimental data. Blood flow information was acquired using a cardiacgated, 2D, respiratory compensated, phase-contrast (PC) cine sequence with through-plane velocity encoding [14]. The cardiac output of the patient was 3.71 L/min, the heart rate 47 beats per minute (cardiac cycle T = 1.277 sec).…”

“…Figure (4) shows measured and reconstructed time-dependent flow rate at the level of the ascending aorta. A 15-term Fourier reconstruction of the flow waveforms is given by [14] (9)…”

“…Pulsatile blood flow. Ascending aortic flow waveforms (in ml/sec) measured by the (PC)-MRI sequence [14]. The electrical analogy in fluid mechanics, where inertia is represented by an inductor, could be explained by the magnetic field flux of the inductance.…”

Characterization of Hemodynamics in Great Arteries of Wild-Type Mouse Using Computational Fluid Dynamics Based on Ultrasound Images

“…13,14 We extracted and adjusted the flow boundary conditions from small animal microultrasound imaging measurement of the mice AAR into 3D digital geometry model reconstruction made by image CAD system in BUAA (Beihang University, Beijing). All boundaries were extended, and the geometry was meshed into refined grid model by the mathematical interpolation technique with high precision.…”