CFD Analysis Study on the Impact of the Coronary Anatomy on the Efficiency of the Coronary Thrombectomy: The Effect of Bend Angles

Li, Yan; Nallamothu, Rajeev; Rafiroiu, D.; Iancu, Adrian Corneliu; Díaz‐Zuccarini, Vanessa; Narracott, Andrew; Hose, D.R.; Lawford, Patricia

doi:10.1007/978-3-642-22586-4_64

Cited by 2 publications

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“…First, the role of hole design in aspiration of the clot was investigated, considering the lowest-viscosity clot and low vacuum pressure (simulations 1-7). Then, the bestperforming hole design for such conditions of low clot viscosity and low vacuum pressure was compared with a generic catheter with no lateral hole (NH) for a range of values of viscosity and pressure (simulations [8][9][10][11][12][13][14][15][16][17]. The results are shown in the form of aspirated clot mass percentage over time period evaluated at the catheter outlet section.…”

Section: Computational Fluid Dynamics Simulationsmentioning

confidence: 99%

“…Computational simulation suggested that the presence of additional holes, axially aligned on the upper side of the catheter, might not be effective (and might even be disadvantageous compared with a single central lumen) if the holes were not in contact with the clot. The two-phase flow approach was also adopted by Li et al (11), who investigated the influence of clot age (simulated with different viscosity values) and catheter bending following the coronary artery curvature. As expected, older thrombi required longer aspiration times, whereas no role for catheter bending was found.…”

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confidence: 99%

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Possible Benefits of Catheters With Lateral Holes in Coronary Thrombus Aspiration: A Computational Study for Different Clot Viscosities and Vacuum Pressures

2014

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According to a number of clinical studies, coronary aspiration catheters are useful tools to remove a thrombus (blood clot) blocking a coronary artery. However, these thrombectomy devices may fail to remove the blood clot entirely. Few studies have been devoted to a systematic analysis of factors affecting clot aspiration. The geometric characteristics of the aspiration catheter, the physical properties of the thrombus, and the applied vacuum pressure are crucial parameters. In this study, the aspiration of a blood clot blocking a coronary bifurcation is computationally simulated. The clot is modeled as a highly viscous fluid, and a two-phase (blood and clot) problem is solved. The effects of geometric variations in the tip of the coronary catheter, including lateral hole size and location, are investigated considering different aspiration pressures and clot viscosities. A Bird-Carreau model is adopted for blood viscosity, while a power law model is used to describe the clot rheology. Computational results for blood clot aspiration show that the presence of holes in the lateral part of the tip of the catheter can be beneficial depending on clot viscosity, hole features, and applied aspiration pressure. In general, the holes are beneficial when the clot viscosity is low, while aspiration catheters without any extra lateral holes exhibit better performance for higher clot viscosity. However, when higher aspiration pressures are applied, the catheters tend to behave relatively similarly in removing clots with various viscosities, reducing the role of the clot viscosity.

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Section: Computational Fluid Dynamics Simulationsmentioning

confidence: 99%

mentioning

confidence: 99%

Possible Benefits of Catheters With Lateral Holes in Coronary Thrombus Aspiration: A Computational Study for Different Clot Viscosities and Vacuum Pressures

2014

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Thrombus Aspiration, from “Heart to Soul”

Iancu

Rafiroiu

Dregoesc

2016

Journal of Cardiovascular Emergencies

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Microvascular obstruction (MVO) is one of the most frequent complications encountered during primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction. The embolization of thrombotic material seems to be the leading cause of MVO, and many clinical trials have demonstrated that thrombus aspiration (TA) may be a useful means of preventing this phenomenon. Continuous advancements in technology have contributed to the development of various devices for thrombus aspiration. However, a review of the literature indicates that there is disagreement regarding the role of TA in the prevention and treatment of MVO. TA is increasingly used in the treatment of acute stroke in patients who are admitted to the hospital within eight hours from the onset of symptoms. This review presents the current knowledge regarding the role of TA in the prevention of MVO.

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CFD Analysis Study on the Impact of the Coronary Anatomy on the Efficiency of the Coronary Thrombectomy: The Effect of Bend Angles

Cited by 2 publications

References 4 publications

Possible Benefits of Catheters With Lateral Holes in Coronary Thrombus Aspiration: A Computational Study for Different Clot Viscosities and Vacuum Pressures

Possible Benefits of Catheters With Lateral Holes in Coronary Thrombus Aspiration: A Computational Study for Different Clot Viscosities and Vacuum Pressures

Thrombus Aspiration, from “Heart to Soul”

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