CEUS LI-RADS: a pictorial review

Bartolotta, Tommaso Vincenzo; Terranova, Maria Chiara; Gagliardo, Cesare; Taibbi, Adele

doi:10.1186/s13244-019-0819-2

Cited by 41 publications

(48 citation statements)

References 67 publications

(78 reference statements)

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“…Nonetheless, their proposal was considered misleading by the ACR and consequently denied [110]. [59,111]. This table includes only CEUS pure blood pool agents (SonoVue, Luminity).…”

Section: Diagnostic Features Of Hepatocellular Carcinoma On Ceusmentioning

confidence: 99%

“…Yang et al [98] reported no significant difference on the dynamic enhancement of HCC using CEUS in patients with or without cirrhosis. [59,111]. This table includes only CEUS pure blood pool agents (SonoVue, Luminity).…”

Section: Hcc Particularities In Nafld Patientsmentioning

confidence: 99%

“…Figure 4. CEUS LI-RADS classification and management of FLLs according to the American College of Radiology[59,111]. This table includes only CEUS pure blood pool agents (SonoVue, Luminity).…”

mentioning

confidence: 99%

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Performance of Ultrasound Techniques and the Potential of Artificial Intelligence in the Evaluation of Hepatocellular Carcinoma and Non-Alcoholic Fatty Liver Disease

Lupșor-Platon

Şerban

Silion

et al. 2021

Cancers

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Global statistics show an increasing percentage of patients that develop non-alcoholic fatty liver disease (NAFLD) and NAFLD-related hepatocellular carcinoma (HCC), even in the absence of cirrhosis. In the present review, we analyzed the diagnostic performance of ultrasonography (US) in the non-invasive evaluation of NAFLD and NAFLD-related HCC, as well as possibilities of optimizing US diagnosis with the help of artificial intelligence (AI) assistance. To date, US is the first-line examination recommended in the screening of patients with clinical suspicion of NAFLD, as it is readily available and leads to a better disease-specific surveillance. However, the conventional US presents limitations that significantly hamper its applicability in quantifying NAFLD and accurately characterizing a given focal liver lesion (FLL). Ultrasound contrast agents (UCAs) are an essential add-on to the conventional B-mode US and to the Doppler US that further empower this method, allowing the evaluation of the enhancement properties and the vascular architecture of FLLs, in comparison to the background parenchyma. The current paper also explores the new universe of AI and the various implications of deep learning algorithms in the evaluation of NAFLD and NAFLD-related HCC through US methods, concluding that it could potentially be a game changer for patient care.

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“…Nonetheless, their proposal was considered misleading by the ACR and consequently denied [110]. [59,111]. This table includes only CEUS pure blood pool agents (SonoVue, Luminity).…”

Section: Diagnostic Features Of Hepatocellular Carcinoma On Ceusmentioning

confidence: 99%

Section: Hcc Particularities In Nafld Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Performance of Ultrasound Techniques and the Potential of Artificial Intelligence in the Evaluation of Hepatocellular Carcinoma and Non-Alcoholic Fatty Liver Disease

Lupșor-Platon

Şerban

Silion

et al. 2021

Cancers

View full text Add to dashboard Cite

show abstract

“…Several international guidelines currently recommend CEUS as a useful imaging modality for the radiological work-up of HCC, such as the LI-RADS lexicon of the American College of Radiology[ 22 , 30 , 31 ].…”

Section: Contrast-enhanced Usmentioning

confidence: 99%

New frontiers in liver ultrasound: From mono to multi parametricity

Bartolotta¹,

Taibbi²,

Randazzo³

et al. 2021

WJGO

Self Cite

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Modern liver ultrasonography (US) has become a “one-stop shop” able to provide not only anatomic and morphologic but also functional information about vascularity, stiffness and other various liver tissue properties. Modern US techniques allow a quantitative assessment of various liver diseases. US scanning is no more limited to the visualized plane, but three-dimensional, volumetric acquisition and consequent post-processing are also possible. Further, US scan can be consistently merged and visualized in real time with Computed Tomography and Magnetic Resonance Imaging examinations. Effective and safe microbubble-based contrast agents allow a real time, dynamic study of contrast kinetic for the detection and characterization of focal liver lesions. Ultrasound can be used to guide loco-regional treatment of liver malignancies and to assess tumoral response either to interventional procedures or medical therapies. Microbubbles may also carry and deliver drugs under ultrasound exposure. US plays a crucial role in diagnosing, treating and monitoring focal and diffuse liver disease. On the basis of personal experience and literature data, this paper is aimed to review the main topics involving recent advances in the field of liver ultrasound.

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“…This algorithm accounts for size, arterial phase hyperenhancement and wash out phenomenon in later phases. Arterial phase hyperenhancement (APHE) of liver lesions is a major determining factor for the classification of HCC by CEUS 9 , 11 , 15 . APHE reflects the process of arterial angiogenesis which is a key component of HCC pathogenesis, where predominantly arterial rather than portal-venous blood supply is drawn by HCC 16 .…”

Section: Introductionmentioning

confidence: 99%

Alteration of contrast enhanced ultrasound (CEUS) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (TIPS)

Chang

Dumitrache

Böhling

et al. 2020

Sci Rep

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Transjugular intrahepatic portosystemic shunt (TIPS) can treat portal hypertensive complications and modifies hepatic hemodynamics. Modification of liver perfusion can alter contrast enhancement dynamics of liver nodules. This study investigated the diagnostic performance of contrast-enhanced ultrasound (CEUS) to diagnose hepatocellular carcinoma (HCC) in cirrhosis with TIPS. In this prospective monocentric observational study, CEUS was used to characterize focal liver lesions in patients at risk for HCC with and without TIPS. Times of arterial phase hyperenhancement (APHE) und washout were quantified. Perfusion-index (PI) and resistance-index (RI) of hepatic artery and portal venous flow parameters were measured via doppler ultrasonography. Diagnostic gold standard was MRI/CT or histology. This study included 49 liver lesions [23 TIPS (11 HCC), 26 no TIPS (15 HCC)]. 26 were diagnosed as HCC by gold standard. Sensitivity and specificity of CEUS to diagnose HCC with and without TIPS were 93.3% and 100% vs. 90.9% and 93.3%, respectively. APHE appeared significantly earlier in patients with TIPS compared to patients without TIPS. TIPS significantly accentuates APHE of HCC in CEUS. CEUS has good diagnostic performance for diagnosis of HCC in patients with TIPS.

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CEUS LI-RADS: a pictorial review

Cited by 41 publications

References 67 publications

Performance of Ultrasound Techniques and the Potential of Artificial Intelligence in the Evaluation of Hepatocellular Carcinoma and Non-Alcoholic Fatty Liver Disease

Performance of Ultrasound Techniques and the Potential of Artificial Intelligence in the Evaluation of Hepatocellular Carcinoma and Non-Alcoholic Fatty Liver Disease

New frontiers in liver ultrasound: From mono to multi parametricity

Alteration of contrast enhanced ultrasound (CEUS) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (TIPS)

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