CEUS – Einsatzmöglichkeiten am Bewegungsapparat

Jäschke, Malte; Weber, Marc‐André; Fischer, Christian

doi:10.1007/s00117-018-0404-6

Cited by 10 publications

(3 citation statements)

References 70 publications

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“…Außerhalb der Oberbauchorgane gibt es ebenfalls Anwendungsmöglichkeiten für CEUS, beispielsweise an der Skelettmuskulatur zur Visualisierung und Quantifizierung der Mikroperfusion [7]. Eine innovative Anwendungsmöglichkeit des CEUS zeigen die Arbeiten von Fischer [10].…”

Section: Kontrastverstärkter Ultraschall (Ceus)unclassified

Ultrasound 2020 – Diagnostics & Therapy: On the Way to Multimodal Ultrasound: Contrast-Enhanced Ultrasound (CEUS), Microvascular Doppler Techniques, Fusion Imaging, Sonoelastography, Interventional Sonography

Kloth

Kratzer

Schmidberger

et al. 2020

Rofo

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Background Ultrasound as a non-ionizing imaging procedure is one of the most important diagnostic procedures in everyday clinical practice. The technology is widely used. Due to constant technical innovations, sonographic procedures, such as contrast-enhanced ultrasound (CEUS), sonoelastography, new microvascular Doppler modalities and, as an example of interventional procedures, sonographically controlled microwave ablation (MWA), are becoming increasingly important in diagnostic imaging and interventional medicine alongside CT and MRI. However, this also requires greater expertise, specialization and qualification on the part of users. Method This review article provides information about the range of technical innovations in ultrasound in recent years and describes the underlying technology, the clinical applications, and their diagnostic value. These are presented in the context of the current literature, explaining their advantages and disadvantages and their clinical value. Results and Conclusion Contrast-enhanced ultrasound (CEUS), microvascular Doppler modalities, fusion imaging and elastography complement B-scan ultrasound and conventional Doppler procedures for various problems. Microwave ablation (MWA) has a firm place as an ablative procedure for local tumor therapy in different organ systems and can be performed under ultrasound guidance. Thanks to new developments, the possibilities of ultrasound are now greater than ever. Knowledge of the technology, indications, and possible applications of newer procedures is essential for adequate patient care. Key Points: Citation Format

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Section: Kontrastverstärkter Ultraschall (Ceus)unclassified

Ultrasound 2020 – Diagnostics & Therapy: On the Way to Multimodal Ultrasound: Contrast-Enhanced Ultrasound (CEUS), Microvascular Doppler Techniques, Fusion Imaging, Sonoelastography, Interventional Sonography

Kloth

Kratzer

Schmidberger

et al. 2020

Rofo

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“…Contrast-enhanced ultrasound (CEUS) can display the tumor microvessel in real time with almost no side effects and a wide range of applications (10,11). The relationship between tumor microvascular angiogenesis regulated by vascular endothelial growth factor (VEGF) and Ki-67 LI has been confirmed in previous research (12).…”

Section: Introductionmentioning

confidence: 99%

Correlation between quantitative parameters of CEUS and Ki-67 labeling index in soft-tissue sarcoma

Wang

et al. 2022

Acta Radiol

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Background Apart from the immunohistochemical Ki-67 labeling index (LI), clinicians need a non-invasive and convenient way to predict the prognosis of patients with soft-tissue sarcoma (STS). Purpose To investigate the correlation between quantitative parameters of contrast-enhanced ultrasound (CEUS) and Ki-67 LI in STS. Material and Methods A total of 25 patients diagnosed with STS who underwent CEUS examination using SonoVue®, between January 2019 to November 2020, were included in the study. They were then divided into a high-proliferation group and low-proliferation group according to 30% Ki-67 positive tumor cells. The quantitative parameters in the semi-automatic time intensity curve analysis software, including arrival time, time to peak, peak intensity, rise time (RT), rise slope, 50% wash-out time, and 50% wash-out intensity, were extracted from the time intensity curve of CEUS by two independent observers. Statistical evaluation of the correlation and difference between CEUS quantitative parameters and Ki-67 LI between the two groups was performed. According to the area under the curve (AUC) analysis, optimal cutoff points of parameters with significant difference were determined. Results CEUS RT of the high-proliferation group in STS was significantly higher than that of the low-proliferation group (ρ = 0.509, P = 0.01). The most reasonable cutoff to distinguish between low- and high-proliferation groups was 10.84 s. The sensitivity, specificity, and the AUC were 86.7%, 80%, and 0.80, respectively. Conclusion CEUS RT was correlated with Ki-67 LI of STS, which can be used as a minimally invasive auxiliary tool to predict the prognosis of STS in clinical practice.

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“…It is easily accessible, cost-efficient, and quick to use [ 9 ]. Furthermore, the used ultrasound contrast agent SonoVue © (Bracco Imaging, Milan, Italy) has a low complication rate [ 10 , 12 ] and CEUS offers real-time examination in the contrast dynamics of the inspected tissues [ 9 ]. In a recent study, CEUS has been shown to be effective in monitoring the vascularity of non-unions [ 9 ] and distinguishing preoperatively based on the microperfusion between infected and non-infected non-unions [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

A Preliminary Study of Contrast-Enhanced Ultrasound (CEUS) and Cytokine Expression Analysis (CEA) as Early Predictors for the Outcome of Tibial Non-Union Therapy

et al. 2018

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The current study investigates if contrast-enhanced ultrasound (CEUS) or cytokine expression analysis (CEA) evaluating vascularization are capable of predicting the outcome of non-union therapy. Patients with tibial non-unions were surgically treated and participated in our follow-up program including perioperative collection of blood as well as CEUS analysis. Two groups were formed: Responders in group 1 (G1, N = 8) and Non-Responders in group 2 (G2, N = 5). Serum cytokine expression and local microperfusion were compared and correlated to the radiologic outcome. Evaluation of TNF-α expression revealed significantly lower values prior to first surgery in G1 (G1: 9.66 ± 0.96 pg/mL versus G2: 12.63 ± 1.2 pg/mL; p = 0.045); whereas after treatment both CEA and CEUS indicated a higher potential for angiogenesis in Responders. Logistic regression modelling revealed the highest predictive power regarding eventual osseous consolidation for the combination of both CEUS and serum CEA. The results provide first evidence regarding a link between changes in the serum expression of distinct pro-angiogenic cytokines and alterations in the local microperfusion assessed via both non-invasive and radiation-free diagnostic modalities. In addition, a combination of CEUS and CEA is a promising novel tool in early prediction of the outcome of non-union therapy.

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CEUS – Einsatzmöglichkeiten am Bewegungsapparat

Abstract: CEUS of the musculoskeletal system is used in clinical trials or off-label. Therefore, it is not well established in clinical routine. However, considering the increasing number of musculoskeletal CEUS applications, this could change in the future.

Cited by 10 publications

References 70 publications

Ultrasound 2020 – Diagnostics & Therapy: On the Way to Multimodal Ultrasound: Contrast-Enhanced Ultrasound (CEUS), Microvascular Doppler Techniques, Fusion Imaging, Sonoelastography, Interventional Sonography

Ultrasound 2020 – Diagnostics & Therapy: On the Way to Multimodal Ultrasound: Contrast-Enhanced Ultrasound (CEUS), Microvascular Doppler Techniques, Fusion Imaging, Sonoelastography, Interventional Sonography

Correlation between quantitative parameters of CEUS and Ki-67 labeling index in soft-tissue sarcoma

A Preliminary Study of Contrast-Enhanced Ultrasound (CEUS) and Cytokine Expression Analysis (CEA) as Early Predictors for the Outcome of Tibial Non-Union Therapy

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