Cetyltrimethylammonium bromide promoted dispersing and incorporation of curcumin into silica particles in alkaline ethanol/water mixture

Liang, Feng; Wang, Min; Hu, Yang; Guo, Zilong; Yang, Wensheng

doi:10.1016/j.colsurfa.2021.126789

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…In the case of curcumin encapsulation in micelles from cetyltrimethylammonium bromide, and their subsequent coating with silica [ 31 ], using thermogravimetric analysis it was determined that about 40% of curcumin was packed into silica particles. A higher cytotoxicity of such a form was found as compared to unmodified curcumin [ 32 ].…”

Section: Nanoparticlesmentioning

confidence: 99%

Methods to Improve the Solubility of Curcumin from Turmeric

Górnicka

Mika

Wróblewska

et al. 2023

Life

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Turmeric is a strong-taste component of spices characteristic of Indian cuisine. It is obtained from the turmeric rhizome (Curcumae longae rhizoma) and has been used for thousands of years not only for culinary purposes, but also for medicinal purposes. It contains a group of organic compounds called curcuminoids. Curcumin is the main representative of this group of compounds which is also most frequently studied. In recent years, bioactive curcuminoids (including curcumin in the first place) have become more and more popular due to a wide spectrum of their biological activity. The anticancer, antibacterial, anti-inflammatory, and antiaging effects of curcumin have been confirmed by numerous in vitro and in vivo studies, as well as in clinical trials. However, an obstacle to simple, clinical application of curcumin is its poor bioavailability (which is due to its hydrophobic nature) and its very weak water solubility. Therefore, many scientists are working on improving the solubility of curcumin in water, which is the topic of the present article. Attempts have been made to combine curcumin with nanoparticles (polysaccharide or silica). Nanosuspensions or complexes with cyclodextrins are also considered. A promising direction is the search for new polymorphic varieties as well as obtaining cocrystals with curcumin which are characterized by better water solubility.

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Section: Nanoparticlesmentioning

confidence: 99%

Methods to Improve the Solubility of Curcumin from Turmeric

Górnicka

Mika

Wróblewska

et al. 2023

Life

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“…Because of its flavoring properties, CUR is used as a food coloring, and as a traditional medicine in India and China for the treatment and prevention of several diseases, such as neurological, oncological, autoimmune, metabolic, cardiovascular, and diabetes, due to its extraordinary activities [3][4][5]23], which have attracted increasing interest from researchers to CUR [25]. However, the use of CUR in therapeutic applications has been limited due to its poor bioavailability and water solubility [4,26,27]. In fact, CUR belongs to Class IV of the Biopharmaceutics Classification System (BCS), whose solubility is about 7.8 µg mL −1 , which can be improved by various strategies of synthesizing appropriate formulations (e.g., solid lipid nanoparticles, solid dispersion, colloidal drug delivery systems, microemulsions, and multi-component crystals) [24].…”

Section: Preparation Of the Cs-and Cs-cur-based Macrobeadsmentioning

confidence: 99%

“…In fact, CUR belongs to Class IV of the Biopharmaceutics Classification System (BCS), whose solubility is about 7.8 µg mL −1 , which can be improved by various strategies of synthesizing appropriate formulations (e.g., solid lipid nanoparticles, solid dispersion, colloidal drug delivery systems, microemulsions, and multi-component crystals) [24]. Encapsulation of CUR within materials, such as CS-based materials, is a strategic approach to improve its dispersibility in aqueous media, chemical stability, controlled release ability, bioactivity, and, thus, use in therapeutic treatment [4,26,28,29]. By way of example, Asif et al [30] reported the synthesis, characterization, and in vitro study of CUR-loaded CS-nanoparticles to enhance the solubility and bioavailability of CUR and to determine the anti-inflammatory and anti-arthritic activities.…”

Section: Preparation Of the Cs-and Cs-cur-based Macrobeadsmentioning

confidence: 99%

Effect of Sodium Hydroxide and Tripolyphosphate on Curcumin Release from Chitosan-Based Macroparticles

Pistone,

de Gaetano,

Piperopoulos

et al. 2023

Materials

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This work deals with the synthesis of bare and curcumin (CUR)-loaded chitosan (CS)-based macroparticles by ionic gelation using sodium hydroxide (NaOH) or sodium tripolyphosphate (TPP). The resulting spherical-shaped macroparticles were studied using various characterization techniques, Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), and Differential Scanning Calorimetry (DSC). The release of CUR from the CS-based particles with respect to time was analyzed, and the encapsulation efficiency and degree of swelling were studied. All formulations showed excellent CUR trapping efficiency, exceeding 90%. In particular, the TPP-crosslinked macrobeads released 34 wt% of the charged CUR within minutes, while the remaining 66 wt% was released slowly. The results indicate that the correct choice of gelling agent and its concentration leads to spherical particles capable of encapsulating CUR and releasing it in a wide range of kinetics so that macrospheres can be used in different applications.

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