Cetyltrimethylammonium Bromide (CTAB)-Loaded SiO2–Ag Mesoporous Nanocomposite as an Efficient Antibacterial Agent

Abstract

To date, Ag-based nanomaterials have demonstrated a high potential to overcome antibiotic resistance issues. However, bare Ag nanomaterials are prone to agglomeration in the biological environment, which results in a loss of antibacterial activity over time. Furthermore, it is still challenging to collect small-sized Ag nanomaterials right after the synthesis process. In this study, spherical-shaped Ag nanoparticles (NPs) (~6–10 nm) were attached on the surface of cetyltrimethylammonium bromide (CTAB)-loaded mesoporous silica nanoparticles (MSNs) (~100–110 nm). Antibacterial activity tests suggested that the obtained nanocomposite can be used as a highly efficient antibacterial agent against both Gram-negative and Gram-positive bacterial strains. The minimum inhibitory concentration (MIC) recalculated to pure Ag weight in nanocomposite was found to be ~1.84 µg/mL (for Escherichia coli) and ~0.92 µg/mL (for Staphylococcus aureus)—significantly smaller compared to values reported to date. The improved antibacterial activity of the prepared nanocomposite can be attributed to the even distribution of non-aggregated Ag NPs per volume unit and the presence of CTAB in the nanocomposite pores.

Green Synthesis of Silver Nanoparticles as an Effective Antibiofouling Material for Polyvinylidene Fluoride (PVDF) Ultrafiltration Membrane

“…In a recent study by Abduraimova and coworkers, the AgNPs were linked to the surface of mesoporous silica nanoparticles (MSN) loaded with cetyltrimethylammonium bromide (CTAB). Due to the antibacterial properties of both CTAB and AgNPs, the nanocomposite showed unprecedented antibacterial effect when recalculated to Ag weight in the composite [34].…”

PVC-SiO2-Ag composite as a powerful biocide and anti-SARS-CoV-2 material

“…Due to its unique characteristics, it has been employed in a wide range of applications, such as cosmetics, food, pharmaceuticals and medicine [ 34 , 35 ]. Taking advantage of SiO 2 as an efficient host for stabilizing Ag NPs and the SiO 2 -Ag heterojunction has attracted considerable attention due to its excellent properties [ 36 – 38 ], in the following study by our research group, Ag NPs were stabilized with semiconductor amorphous SiO 2 to form a SiO 2 -Ag heterojunction. This heterojunction was immobilized in a polymeric matrix (ethyl vinyl acetate), to render a highly virucide material [ 31 ].…”

Green Synthesis and Incorporation of Sericin Silver Nanoclusters into Electrospun Ultrafine Cellulose Acetate Fibers for Anti-Bacterial Applications

“…It is believed that the bacterial cell can be destroyed upon its the interaction with the Ag ion. The positively charged Ag ions, due to their strong affinity to sulfur proteins, adhere to the cell wall and cytoplasmic membrane [ 5 , 6 , 7 ]. This results into the blockage of bacterial respiratory system and demolishing the cell production.…”