Cetylpyridiniumâiodomercurate PVC membrane ion selective electrode for the determination of cetylpyridinium cation in Ezafluor mouth wash and as a detector for some potentiometric titrations

Abbas, Mohammed Nooredeen; Mostafa, Gamal A. E.; Homoda, Atef M.A.

doi:10.1016/s0039-9140(00)00496-3

Cited by 43 publications

(12 citation statements)

References 11 publications

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“…ISE's are known to offer an excellent low cost tool for the selective, sensitive and rapid determination of a vast variety of analytes in different fields of application, 9-13 including pharmaceutical analysis. 9,11,12 The present study aims to develop a potentiometric sensor for the selective, accurate and fast determination of fexofenadine in its pharmaceutical preparations.…”

Section: Introductionmentioning

confidence: 99%

A Novel Membrane Sensor for Histamine H1-Receptor Antagonist “Fexofenadine”

2004

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The construction and general performance of thirteen new polymeric membrane sensors for the determination of fexofenadine hydrochloride based on its ion exchange with reineckate, tetraphenylborate and tetraiodomercurate have been studied. The effects of membrane composition, type of plasticizer, pH value of sample solution and concentration of the analyte in the sensor internal solution have been thoroughly investigated. The novel sensor based on reineckate exchanger shows a stable, potentiometric response for fexofenadine in the concentration range of 1 × 10 -2 -2.5 × 10 -6 M at 25˚C that is independent of pH in the range of 2.0 -4.5. The sensor possesses a Nernstian cationic slope of 62.3 ± 0.7 mV/concentration decade and a lower detection limit of 1.3 × 10 -6 M with a fast response time of 20 -40 s. Selectivity coefficients for a number of interfering ions and excipients relative to fexofenadine were investigated. There is negligible interference from almost all studied cations, anions, and pharmaceutical excipients, however, citrizine that has a structure homologous to that of fexofenadine was found to interfere. The determination of fexofenadine in aqueous solution shows an average recovery of 99.83% with a mean relative standard deviation (RSD) of 0.5%. Direct potentiometric determination of fexofenadine in tablets gave results that compare favorably with those obtained by standard spectrophotometric methods. Potentiometric titration of fexofenadine with phosphomolybdic acid as a titrant has been monitored with the proposed sensor as an end point indicator electrode.

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Section: Introductionmentioning

confidence: 99%

A Novel Membrane Sensor for Histamine H1-Receptor Antagonist “Fexofenadine”

2004

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“…This composition is given in Table 1. For all constructed electrodes, the percentage of ion-pair ranging between 1 and 2% was found to offer better slopes and correlation coefficients, in agreement with literature data. 10,16,17 The results obtained with 2% ion-pair content (PTA or PMA or TPB) for the two plasticizers are summarized in Table 2. The limit of detection was estimated by the IUPAC recommendations.…”

Section: Resultsmentioning

confidence: 99%

Potentiometric Sensors for the Determination of Trifluoperazine Hydrochloride in Pharmaceutical Preparations

et al. 2009

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“…[3][4][5] Potentiometric methods using ion-selective electrodes have wide applications [6][7][8][9][10][11] because they are simple, economical and available over a wide range of different areas, and offer sufficient selectivity towards the drug in the presence of various pharmaceutical excipients. The low cost, ease of use and maintenance, the simplicity and speed of assay procedure and the reliability of the analytical information make the ionselective electrodes very attractive for the assay of pharmaceutical products.…”

Section: Introductionmentioning

confidence: 99%

Mebendazole Selective Membrane Sensor and Its Application to Pharmaceutical Analysis

et al. 2007

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IntroductionMebendazole (MBZ) (5-benzoyl-2-benzimidazolylcarbamic acid methyl ester) (C16H13N3O2) is a broad spectrum anthelmintic drug producing high cure rates in infestations by ascaris, thread worms, hook worms and whip worms.1,2 MBZ causes slow immobilization and death of the worms by selectively and irreversibly blocking uptake of glucose and other nutrients in susceptible adult intestines where helminths dwell.In recent years, potentiometric membrane sensors have been widely used in pharmaceutical analysis. [3][4][5] Potentiometric methods using ion-selective electrodes have wide applications 6-11 because they are simple, economical and available over a wide range of different areas, and offer sufficient selectivity towards the drug in the presence of various pharmaceutical excipients. The low cost, ease of use and maintenance, the simplicity and speed of assay procedure and the reliability of the analytical information make the ionselective electrodes very attractive for the assay of pharmaceutical products.The different analytical techniques available in the literature for the quantitative determination of MBZ include spectrophotometry, 12 high performance liquid chromatography, [13][14][15][16][17][18] liquid chromatography, 19 thin layer chromatography 20 and cathodic stripping voltammetry. 21 Most of these methods are complicated and need sophisticated instruments.In continuation to our work on drug analysis, 22-25 an attempt has been made to develop an electrochemical sensor for the anthelmintic drug mebendazole.The present work describes the fabrication, optimization and some possible applications of a novel MBZ PVC sensor based on the use of a mebendazole-silicotungstate ion pair complex as the electro active material and bis(2-ethylhexyl)phthalate (BEP) as plasticizer. The developed sensor displays high selectivity, long term stability, fast response and applicability over a wide range of pH and drug concentrations. Experimental Reagents and chemicalsAll chemicals used in the study were of highest purity available and were used without further purification. Polyvinyl chloride powder (PVC) of high molecular weight was supplied by Merck. Dibutyl sebacate (DBS), bis(2-ethylhexyl)phthalate (BEP), bis(2-ethylhexyl)adipate (BEA), bis(2-ethylhexyl)sebacate (BES), di-n-butyl phthalate (DBP), phosphotungstic acid (PTA), molybdophosphoric acid (MPA) and silicotungstic acid (STA) were purchased from Lancaster and used as received. Tetrahydrofuran (THF) was obtained from s.d. fine chemicals and all of the metal salts used (all from Merck) were of the highest purity available. Aqueous solutions of the salts were prepared by dissolving the appropriate salt or diluting standard solutions as specified in doubly distilled water. Aqueous solutions of the drug were freshly prepared by accurate dilutions of a standard 10 -1 M stock drug solution using dilute nitric acid (10% v/v) as solvent. Pure-grade MBZ was obtained as a gift sample. Pharmaceutical formulations containing MBZ were obtained from local drug stores....

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Cetylpyridiniumâiodomercurate PVC membrane ion selective electrode for the determination of cetylpyridinium cation in Ezafluor mouth wash and as a detector for some potentiometric titrations

Cited by 43 publications

References 11 publications

A Novel Membrane Sensor for Histamine H1-Receptor Antagonist “Fexofenadine”

A Novel Membrane Sensor for Histamine H1-Receptor Antagonist “Fexofenadine”

Potentiometric Sensors for the Determination of Trifluoperazine Hydrochloride in Pharmaceutical Preparations

Mebendazole Selective Membrane Sensor and Its Application to Pharmaceutical Analysis

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Cetylpyridiniumâiodomercurate PVC membrane ion selective electrode for the determination of cetylpyridinium cation in Ezafluor mouth wash and as a detector for some potentiometric titrations

Cited by 43 publications

References 11 publications

A Novel Membrane Sensor for Histamine H1-Receptor Antagonist “Fexofenadine”

A Novel Membrane Sensor for Histamine H1-Receptor Antagonist “Fexofenadine”

Potentiometric Sensors for the Determination of Trifluoperazine Hydrochloride in Pharmaceutical Preparations

Mebendazole Selective Membrane Sensor and Its Application to Pharmaceutical Analysis

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Product

Resources

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Cetylpyridiniumâiodomercurate PVC membrane ion selective electrode for the determination of cetylpyridinium cation in Ezafluor mouth wash and as a detector for some potentiometric titrations