“…20 potential candidates underwent full-text review, of which 10 ( Bengala et al, 2009;Pinto et al, 2011;Dewdney et al, 2012;Sun et al, 2012;Helbling et al, 2013;Liang et al, 2017;Hasegawa et al, 2017;Merx et al, 2017;Leichman et al, 2018;Pinto et al, 2018)were adequate for eligibility, after excluding 10 studies which were deemed inadequate because they did not focus on KRAS-wild type LARC patients (shown in Figure 1). Among the eligible studies, six (Bengala et al, 2009;Dewdney et al, 2012;Sun et al, 2012;Liang et al, 2017;Hasegawa et al, 2017;Leichman et al, 2018) focus on the efficacy of cetuximab while the other four (Pinto et al, 2011;Helbling et al, 2013;Merx et al, 2017;Pinto et al, 2018) panitumumab. Concerning the country/ district where these trials were conducted, three (Bengala et al, 2009;Pinto et al, 2011;Pinto et al, 2018) were in Italy, one (Merx et al, 2017) in Germany, one (Helbling et al, 2013) in Switzerland & Hungary, one (Dewdney et al, 2012) in the United Kingdom, Spain & Sweden, one (Leichman et al, 2018) in the United States of America, one (Sun et al, 2012) in the mainland of China, one (Liang et al, 2017) in Taiwan, and one (Hasegawa et al, 2017) in Japan.…”