Cetrorelix in an oral contraceptive-pretreated stimulation cycle compared with buserelin in IVF/ICSI patients treated with r-hFSH: a randomized, multicentre, phase IIIb study

Huirne, Judith A F; Hugues, Jean‐Noël; Pirard, Céline; Fischl, Franz; Sage, Julien; Pouly, J ­L; Obruca, A.; Braat, D.; Loenen, Andre C.D. van; Lambalk, Cornelis B.

doi:10.1093/humrep/del030

Cited by 49 publications

(45 citation statements)

References 18 publications

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“…Ovarian stimulation regimens, sperm handling, oocyte retrieval and conventional IVF/ICSI procedures were carried out as previously described, and remained constant for the whole study period [10,11]. Fertilization was assessed 18 h after IVF/ICSI.…”

Section: Ivf and Laboratory Proceduresmentioning

confidence: 99%

Clinical predictive criteria associated with live birth following elective single embryo transfer

Sifer

Herbemont

Adda-Herzog

et al. 2014

European Journal of Obstetrics & Gynecology and Reproductiv

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Section: Ivf and Laboratory Proceduresmentioning

confidence: 99%

Clinical predictive criteria associated with live birth following elective single embryo transfer

Sifer

Herbemont

Adda-Herzog

et al. 2014

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Ovarian stimulation regimens, sperm preparation, oocyte retrievals, and cIVF/ICSI procedures were carried out as previously described (15,16). Fertilization was assessed 18 hours after IVF/ ICSI.…”

mentioning

confidence: 99%

Biological predictive criteria for clinical pregnancy after elective single embryo transfer

Sifer¹,

Sermondade²,

Poncelet³

et al. 2011

Fertility and Sterility

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“…Estrogen pretreatment was also recently found useful in programming GnRH antagonist cycles [23]. Oral contraceptive [24,25,26] and luteal progesterone pretreatment [24] have also been studied in the same context. In addition, early initiation of the GnRH antagonist on cycle day 1 has been studied in normo- [27] or high-responding [28] patients.…”

Section: Discussionmentioning

confidence: 99%

Controlled Ovarian Stimulation Using a Long Gonadotropin-Releasing Hormone<b> </b>Antagonist Protocol: A Proof of Concept and Feasibility Study

Weissman

Ravhon²,

Steinfeld³

et al. 2013

Gynecol Obstet Invest

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Background/Aims: To evaluate the feasibility of a long protocol of controlled ovarian stimulation prior to in vitro fertilization (IVF) and embryo transfer with a gonadotropin-releasing hormone (GnRH) antagonist used for pituitary and ovarian suppression. Methods: Thirty patients undergoing IVF/intracytoplasmic sperm injection were randomized into two groups. The control group (n = 16) received a standard flexible GnRH antagonist protocol. Ovarian stimulation consisted of 225 IU/day of recombinant follicle-stimulating hormone for 5 days, followed by 225 IU/day of human menopausal gonadotropin until human chorionic gonadotropin (hCG) administration. The study group (n = 14) received 0.25 mg of GnRH antagonist daily for 7 days, thereafter, upon confirmation of pituitary and ovarian suppression, ovarian stimulation was commenced with the same protocol as used in the control group. Hormone and follicle dynamics, as well as laboratory characteristics and cycle outcome, were compared for both groups. Results: Both groups were comparable in baseline characteristics. Pituitary and ovarian suppression were effectively achieved in 12/14 patients in the study group. The duration of ovarian stimulation and gonadotropin consumption were similar in both groups, as was also the number and size of follicles on hCG day. Conclusion: The results of our study confirm the feasibility of a long GnRH antagonist protocol. This regimen could become another option to optimize GnRH antagonist protocols, and should thus be further explored.

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Cetrorelix in an oral contraceptive-pretreated stimulation cycle compared with buserelin in IVF/ICSI patients treated with r-hFSH: a randomized, multicentre, phase IIIb study

Abstract: Cetrorelix pretreated with OCs resulted in similar number of oocytes retrieved compared with a long buserelin protocol. Both regimens were well tolerated and allowed scheduling of the oocyte retrieval, with only small number of retrievals falling on a weekend or public holiday.

Cited by 49 publications

References 18 publications

Clinical predictive criteria associated with live birth following elective single embryo transfer

Clinical predictive criteria associated with live birth following elective single embryo transfer

Biological predictive criteria for clinical pregnancy after elective single embryo transfer

Controlled Ovarian Stimulation Using a Long Gonadotropin-Releasing Hormone<b> </b>Antagonist Protocol: A Proof of Concept and Feasibility Study

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