Cetones α perfluorees

Strategies for nucleophilic, electrophilic, and radical trifluoromethylations

“…Replacement of CFCs and halons led to an increased commercial production of trifluoromethyl iodide, in particular for application as a fire extinguishing agent, etching gas, coolant, and trifluoromethylating agent. In early works, trifluoromethyl iodide was exploited, for example, in the photochemical trifluoromethylation of steroids [121][122][123] and in the photochemical reaction with enamines to produce a-trifluoromethyl ketones [124,125].…”

Copper‐Catalyzed Trifluoromethylation of Unactivated Olefins

“…Early research into C À CF 3 bond formation primarily focused on the exploration of nucleophilic and radical sources of the CF 3 group. [5] These efforts resulted in the development of many trifluoromethylation reactions, including nucleophilic addition to carbonyl electrophiles, [6,7] halotrifluoromethylation of olefins, [8] enolate addition to the CF 3 radical, [9] and formation of aryl À CF 3 bonds. [10,11] While less extensively explored, the use of electrophilic trifluoromethylating reagents enabled the trifluoromethylation of a range of nucleophiles.…”

Versatile Fluorinated Building Blocks by Stereoselective (Per)fluoroalkenylation of Ketones

“…In the past, perfluoroalkyl halides ( R f ‐X) have been applied for the synthesis of perfluoroalkyl‐substituted carbonyl compounds, olefins, alkanes, and (hetero)arenes[7a], [7b], [7c], [7d], due to their cost‐efficiency, step economy, and scalability. However, much less attention focused on their use as perfluoroalkenyl‐precursors (Scheme A).…”