Cetoacidosis diabética

Hofheinz, Sylvia Belda; Guerra, Pablo; Cuesta, Alba Palacios

doi:10.1016/s1696-2818(14)70169-6

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…The worldwide prevalence is 0.8 to 4.6/1,000 population, being higher in the group of 10 to 14 years, while its incidence is increasing, it is estimated that 86,000 children have DM1 each year [2,3]. Diabetic ketoacidosis (DKA) is the most serious and frequent state of decompensation, presenting at diagnosis in up to 70% of cases; in patients already known to be diagnosed with DM1, the risk of presenting DKA is 1 to 10% per patient/year, more frequently in patients with poor control [4]. It is caused by a decrease in insulin concentration and an increase in counter-regulatory hormones (catecholamines, cortisol, growth hormone and glucagon), with an increase in glucose production in the liver and a decrease in the peripheral utilization of glucose, causing hyperglycemia and hyperosmolar state.…”

Section: Introductionmentioning

confidence: 99%

Glycemic status and hyperchloremia as risk factors for acute kidney injury in children with diabetic ketoacidosis

Ornelas-Carreón

Rojas-Artiaga

Ruiz-Jaramillo

et al. 2023

Preprint

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Introduction. Acute kidney injury (AKI) is a frequent complication in diabetic ketoacidosis (DKA). OBJECTIVE. To analyze the factors associated with nephrotoxicity in pediatric patients with DKA. Material and methods. We performed a case-control study. Records of patients under 18 years of age with DKA were analyzed from January 2016 to January 2021 at the Hospital General Leon, Guanajuato, Mexico. Those who presented AKI diagnosed with KDIGO criteria were defined as cases and clinical and biochemical data were compared with the group that did not present AKI. Results. Thirty records of patients with DKA were reviewed, of which 15 developed AKI (50%) which on average resolved by the fourth day of treatment. In this group there were higher values of serum chloride (112±4 mEq/L vs. 105±4 mEq/L, p<0.001, power 99%) and glycosylated hemoglobin (HbA1c) (14.2±2.4% vs 11.5±2.4%, p=0.003, power 90%). The ROC curve analysis for serum chlorine and LRA had an area under the curve (AUC) of 0.9 (95% CI 0.69-0.97) with a cut-off point of 110 mEq/L and for HbA1c AUC of 0.8 (95% CI 0.6-0.9) with a cut-off point of 12.9%. The level of HbA1c ≥13% at admission as a risk factor for developing AKI showed an OR of 11 (95% CI 2-60) (p=0.006) and serum chloride ≥110 mEq/L an OR of 42 (95% CI 5 -346) (p=0.0005). Conclusions. Half of the children with DKA had some degree of AKI. Serum chloride level ≥110 mEq/L or HbA1c ≥13% at admission increases the risk of AKI.

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Section: Introductionmentioning

confidence: 99%

Glycemic status and hyperchloremia as risk factors for acute kidney injury in children with diabetic ketoacidosis

Ornelas-Carreón

Rojas-Artiaga

Ruiz-Jaramillo

et al. 2023

Preprint

View full text Add to dashboard Cite

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Cetoacidosis diabética: un cuadro de importancia en pediatría

Brizuela¹

2023

Acta Médica Grupo Ángeles

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La diabetes mellitus es una de las enfermedades crónicas más frecuentes de la edad pediátrica, mientras que la que la cetoacidosis es la principal causa de morbimortalidad en niños que padecen diabetes mellitus tipo 1. Éste es uno de los motivos de urgencias más comunes en la población adolescente, para quienes es de vital importancia la fluidoterapia, así como un manejo minucioso que evite complicaciones, dentro de las cuales el edema cerebral es la más temida; este padecimiento fue descrito desde 1930 y es una de las principales causas de muerte. Por ello es importante conocer datos acerca del mismo, como son sus criterios diagnósticos, además de la manera en que puede llegar a tratarse y prevenirse.

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Cetoacidosis diabética

Cited by 2 publications

References 32 publications

Glycemic status and hyperchloremia as risk factors for acute kidney injury in children with diabetic ketoacidosis

Glycemic status and hyperchloremia as risk factors for acute kidney injury in children with diabetic ketoacidosis

Cetoacidosis diabética: un cuadro de importancia en pediatría

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