Cetirizine reduces inflammatory cell recruitment and ICAM-1 (or CD54) expression on conjunctival epithelium in both early- and late-phase reactions after allergen-specific challenge

Ciprandi, Giorgio; Buscaglia, S; Pesce, Giampaola; Passalacqua, Giovanni; Rihoux, J P; Bagnasco, Marcello; Canonica, Giorgio Walter

doi:10.1016/s0091-6749(95)70324-1

Cited by 133 publications

(79 citation statements)

References 33 publications

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“…The hyperexpression of ICAM–1 on epithelial conjunctival cells after allergen–specific conjunctival challenge in atopics was also inhibited [27] as well as the hyperexpression of VCAM–1 in the skin of atopic dermatitic subjects [28]. …”

Section: Modulation Of Cell Trafficking and Adhesion Molecule Expressionmentioning

confidence: 99%

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

Rihoux

Michel²,

Arnold³

et al. 1999

Int Arch Allergy Immunol

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Some recent clinical studies carried out with the potent H₁–antihistamine cetirizine (CTZ) suggest that this drug could be useful for the treatment of mild to moderate asthma and even for the prevention of the disease. Besides a potent antagonism of H₁–receptors at bronchial level, this drug was also shown to exert a large series of anti–inflammatory effects in in vitro, ex vivo and in vivo pharmacological models and also in clinical situations in atopic subjects. All the data collected up to now suggest the possible existence in the molecule of a central key mechanism of action on resident cells especially involved in cell trafficking and bronchial inflammation, i.e a down–regulating effect on the nuclear factor_KB (NF_KB). This hypothesis was tested on human endothelial cells and a human epithelial pulmonary cell line using different experimental methods. The results showed that CTZ down–regulates the TNF–α–induced hyperactivation of NF_KB in these two different resident cells at physiological concentrations.

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Section: Modulation Of Cell Trafficking and Adhesion Molecule Expressionmentioning

confidence: 99%

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

Rihoux

Michel²,

Arnold³

et al. 1999

Int Arch Allergy Immunol

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“…The clinical benefit of H1R blockade lies largely in inhibition of pruritus. However, broader antiinflammatory effects have been ascribed to H1R blockers, including inhibitory effects on adhesion molecule expression (21,22) and inhibition of eosinophil chemotaxis (23). An H1R antagonist has also been shown to inhibit the generation of IL-4 and IL-13 by human basophils (24).…”

Section: Introductionmentioning

confidence: 99%

The H1 histamine receptor regulates allergic lung responses

Bryce¹

2006

Journal of Clinical Investigation

123

102

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Histamine, signaling via the type 1 receptor (H1R), has been shown to suppress Th2 cytokine production by in vitro cultured T cells. We examined the role of H1R in allergic inflammation in vivo using a murine asthma model. Allergen-stimulated splenic T cells from sensitized H1R -/-mice exhibited enhanced Th2 cytokine production. Despite this Th2 bias, allergen-challenged H1R -/-mice exhibited diminished lung Th2 cytokine mRNA levels, airway inflammation, goblet cell metaplasia, and airway hyperresponsiveness (AHR). Restoration of pulmonary Th2 cytokines in H1R -/-mice by intranasal IL-4 or IL-13 restored inflammatory lung responses and AHR. Further investigation revealed that histamine acts as a T cell chemotactic factor and defective T cell trafficking was responsible for the absence of lung inflammation. Cultured T cells migrated in response to histamine in vitro, but this was ablated by blockade of H1R but not H2R. In vivo, allergen-specific WT but not H1R -/-CD4 + T cells were recruited to the lungs of naive recipients following inhaled allergen challenge. H1R -/-T cells failed to confer airway inflammation or AHR observed after transfer of WT T cells. Our data establish a role for histamine and H1R in promoting the migration of Th2 cells into sites of allergen exposure.

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“…In response to the third question, antihistamines, specifically cetirizine, may have an anti-inflammatory effect [39,40]. This regulation of inflammatory processes can positively impact ADHD endpoints in children with comorbid diseases.…”

Section: Discussionmentioning

confidence: 99%

Attention Deficit Disorder and Allergic Rhinitis - Are They Related?

Melamed¹

2016

Int J Aller Medcations

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The association between ADHD and allergy remains controversial. Our previous findings suggest that nerve growth factor may link the nervous and immune systems. The primary objective of this study was to determine if a combination of cetirizine + methylphenidate is effective in children with comorbid ADHD and allergic rhinitis. We also examined the role of nerve growth factor in these comorbidities. Our randomized, double-blind, placebo-controlled, crossover study enrolled 38 children diagnosed with comorbid ADHD and allergy using cetirizine ( = 12), sustained-release methylphenidate ( = 12), or cetirizine + methylphenidate ( = 14). Endpoints compared baseline to posttreatment evaluations for allergic rhinitis and ADHD scores. Serum nerve growth factor levels were measured using ELISA. For allergy endpoints, combination therapy produced results superior to individual therapy. For ADHD, similar scores were achieved for individual therapy; however, combination therapy resulted in improved scores. Nerve growth factor levels were downregulated following this trend. We conclude that ADHD and allergic rhinitis may have common mechanism and represent a comorbid condition that links the nervous system to the immune system. Further studies are needed.

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Cetirizine reduces inflammatory cell recruitment and ICAM-1 (or CD54) expression on conjunctival epithelium in both early- and late-phase reactions after allergen-specific challenge

Cited by 133 publications

References 33 publications

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

The H1 histamine receptor regulates allergic lung responses

Attention Deficit Disorder and Allergic Rhinitis - Are They Related?

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