Cetirizine-induced urticarial reaction

Karamfilov, Theodor; Wilmer, A.; Hipler, Uta‐Christina; Wollina, Uwe

doi:10.1046/j.1365-2133.1999.02849.x

Cited by 29 publications

(13 citation statements)

References 11 publications

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“…Patients with urticaria have normal or negative reactions to IgE, other immunologic workup, and a prick test, so it can be said that the eruption is caused by non-IgE-dependent pathogenesis. 9,10 The instant patient's serum has a normal level of IgE. A negative result to prick tests with hydroxyzine and cetirizine strongly suggests the patient has a non-IgE-dependent intolerance reaction, which is not a type I sensitization.…”

Section: Discussionmentioning

confidence: 96%

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Cutaneous drug eruption from cetirizine and hydroxyzine

Lew

Haw

Lee

2004

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 96%

“…[8][9][10][11][12][13][14][15][16][17][18][19][20] According to the reports, drug eruption from cetirizine, unlike eruptions from hydroxyzine and other drugs, is usually in the form of urticaria. Because of that, it is sometimes misinterpreted as urticaria that fails to respond to antihistamines.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous drug eruption from cetirizine and hydroxyzine

Lew

Haw

Lee

2004

Journal of the American Academy of Dermatology

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“…Hypersensitivity to a single antihistamine resulting in hives and even anaphylaxis has been reported for cetirizine, levocetirizine, hydroxyzine, ebastine, and fexofenadine [3489]. Hypersensitivity between different classes of antihistamines has rarely been reported.…”

Section: Discussionmentioning

confidence: 99%

Bepotastine-induced urticaria, cross-reactive with other antihistamines

Kang

Lee

2016

Asia Pacific Allergy

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Second-generation antihistamines are widely prescribed for the control of symptoms of allergic inflammation such as itchy hives, coryza, and itchy eyes. In rare circumstances, these drugs might provoke allergic inflammation. Hypersensitivity to bepotastine besilate, a second-generation antihistamine has never been reported. A 17-year-old schoolgirl, whose paroxysmal itchy hives had been controlled with bepotastine, experienced aggravation of the hives. An oral provocation test confirmed her hypersensitivity to bepotastine and cross-reactivity to levocetirizine. She showed no reaction to chlorpheniramine, ketotifen, or olopatadine among the 13 antihistamines tested. While searching for an antihistamine to control her itchy hives, we found that she also exhibited cross-reactivity to various antihistamines with different chemical structures from that of bepotastine, which is not predicted according to the chemical classification of antihistamines. We report a case of hypersensitivity to bepotastine besilate in a patient with chronic spontaneous urticaria.

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“…Although cetirizine is well tolerated when administered orally, it can rarely cross-react with other piperazine derivatives and cause a drug eruption [5] , usually in the form of urticaria or fixed drug eruption. To our knowledge, only 8 cases of skin eruption due to cetirizine have been reported so far [2,[5][6][7][8][10][11][12] ; moreover, only 2 adverse reactions have recently been reported with levocetirizine (a case of fixed drug eruption [3] and a case of urticaria [9] ).…”

Section: Discussionmentioning

confidence: 99%