Cestocidal activity of Acacia auriculiformis

Abstract

The cestocidal activity of Acacia auriculiformis was evaluated using rats each harbouring a single adult worm oi Hymenolepis diminuta. The ethanol extract (300 mg/kg/day) and the saponins (200 mg/kg/day) obtained from the funicles of A. auriculiformis, were administered orally to two groups each of 10 rats, respectively, on day 20 after oral inoculation with a single cysticercoid of H. diminuta. Adult worms were expelled within 5 days from rats treated with the ethanol extract and within 3 days from those treated with saponins. No appreciable side effects were observed in the treated rats.

Anthelmintic activity ofAcacia oxyphyllastem bark againstAscaridia galli

“…Following this basic technique, several medicinal plants such as Albizzia lebbek Bentham (Mimosaceae), Allium sativum Linnaeus (Liliaceae), A. santonica Linnaeus (Liliaceae), Cardiospermum halicacabum Linnaeus (Sapindaceae), Coriandrum sativum Linnaeus, Cucurbita mexicana Damm (Cucurbitaceae), Neurolaena lobata Linnaeus (Asteraceae), Perilla frutescens Linnaeus (Lamiaceae), Spigelia anthelmia Linnaeus (Loganiaceae), Spondias mombin Linnaeus (Anacardiaceae), Polyalthia suaveolens Engler & Diels (Annonaceae), Vernonia amygdalina Linnaeus (Asteraceae), and Zingiber officinale Roscoe (Zingiberaceae) have already been documented to show anthelmintic activity against different nematodes of veterinary importance (Akhtar et al, 2000;El Garhy & Mahmoud, 2002;Iqbal et al, 2003;Boonmars et al, 2005;Fujimaki et al, 2005;Ademola et al, 2005Ademola et al, , 2007Eguale et al, 2007;Adedapo et al, 2007). A closely related species of Acacia used in the present study, A. auriculiformis Cunningham extract, reportedly caused significant activity against the nematode Dirofilaria immitis Leidy of dogs (Chakraborty et al, 1995), the bovine nematode Setaria cervi Kunth (Ghosh et al, 1993) and a cestode Hymenolepis diminuta Sturdevant (Ghosh et al, 1996). Feeding of A. karoo Hayne (Leguminosae) leaves also caused significant decrease in the fecal egg count of the nematode Haemonchus contortus Rudolphi in goats (Kahiya et al, 2003).…”

Antigenotoxic activities of crude extracts from Acacia salicina leaves

“…Acacia (Fabaceaes) is an evergreen tree that is a native of Australia, but now is widely distributed in the Mediterranean area. Acacia species are frequently used for the treatment of various illnesses because of their reputed pharmacological effects; published information indicates that Acacia has hypoglycemic effects [Wadood et al, 1989], anti-inflammatory activity [Dafallah and Al-Mustapha, 1996], cestocial activity [Ghosh et al, 1996], activity against platelet aggregation [Shah et al, 1997], spasmogenic and vasoconstrictor activities [Amos et al, 1999], antihypertensive and antispasmodic activities [Gilani et al, 1999], and inhibitory effects against hepatitis C virus [Hussein et al, 2000]. In Tunisian traditional medicine, the uses of Acacia differ according to the species and according to the region of the country.…”

Antiparasitic activity of methanolic extract of Acacia oxyphylla (Leguminosae) against Raillietina echinobothrida

“…The most active components of this genus are supposed to be the condensed tannins (CTs), a class of phenolic secondary metabolites that rarely have toxic effects. The genus also contains saponins like Acaciaside A and B which have been proven to have nematocidal and cestocidal activity (Ghosh et al 1993(Ghosh et al , 1996. Acacia oxyphylla, used widely against gastrointestinal worms in the rural traditional medicine practised among the Mizo natives in North-East India, has recently been reported as responsible for alteration of surface ultrastructure in cestode (Roy et al 2007;Dasgupta et al 2010).…”