Cesarean myomectomy for solitary uterine fibroids: Is it a safe procedure?

Özcan, Aykut; Kopuz, Aycan; Turan, Volkan; Şahin, Çağdaş; Töz, Emrah; Aksoy, Selin; Özeren, Mehmet

doi:10.17772/gp/57833

Cited by 17 publications

(13 citation statements)

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“…ULs are asymptomatic in 50-40% of women over 35 years old; however, it could be associated with symptoms such as menorrhagia, pain, infertility, and recurrent pregnancy loss [2]. UL may affect the pregnancy in one third of women and enlarge its size in the first and third trimesters of pregnancy due to altered levels of hormones especially estrogen [3]. Different risk factors may affect UL development including: obesity, ethnicity, family history, diet rich in meat, smoking, age increasing, use of oral contraceptive pills, and biological biomarkers [4].…”

Section: Introductionmentioning

confidence: 99%

The −2549 insertion/deletion polymorphism of VEGF gene associated with uterine leiomyoma susceptibility in women from Southeastern Iran

Keshavarzi

Salimi

Mohammadpour‐Gharehbagh

et al. 2017

Ginekol Pol

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Objectives: Vascular endothelial growth factor (VEGF) is an important angiogenic factor that regulates angiogenesis and mediates sex steroid-induced cell growth. The present study investigated the association of VEGF gene-2578C/A (rs699947) and −2549 insertion/deletion polymorphisms in the promoter region of VEGF-A gene and uterine leiomyoma susceptibility in Southeast of Iran. Material and methods:One hundred and fifty five women with uterine leiomyoma and 157 age, BMI, and ethnicity matched healthy women were enrolled in this study. VEGF gene -2578C/A polymorphism genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, and the -2549 insertion/deletion polymorphism was analyzed by PCR method. Results:The frequency of alleles and genotypes of VEGF-2578C/A polymorphism was not different between women with uterine leiomyoma and the controls; however, a significant association was revealed between II genotype of -2549 insertion/deletion (I/D) polymorphism of VEGF gene and uterine leiomyoma. Conclusions:The findings showed that VEGF gene -2549 insertion/deletion polymorphism was associated with uterine leiomyoma.

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Section: Introductionmentioning

confidence: 99%

The −2549 insertion/deletion polymorphism of VEGF gene associated with uterine leiomyoma susceptibility in women from Southeastern Iran

Keshavarzi

Salimi

Mohammadpour‐Gharehbagh

et al. 2017

Ginekol Pol

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“…Ozcan et al, retrospectively reviewed 306 patients with leiomyoma. 8 There were 82 women who underwent CM and 224 women with myomas had caesarean only (CO). They observed a significant difference in hospital stay (p=0.006) and operation duration (p<0.05) in both groups but no significant difference in the mean postoperative Hb.…”

Section: Resultsmentioning

confidence: 99%

“…Incidence of uterine myomas in pregnancy varies from 1.6% to 12.6% with higher prevalence in elderly pregnant women or women undergoing in vitro fertilization. [7][8][9][10][11] They are commonly seen in African-American women with an incidence of 18% followed by 8% in white women and 10% in Hispanic women. 10 They are more common in primigravida over 35 years of age due to responsive growth to ovarian steroid hormones, estrogen and progesterone and are rarely seen before puberty.…”

Section: Myomas In Pregnancymentioning

confidence: 99%

“…10,12 Adverse obstetric complications are reported in 10%-40% of cases like spontaneous miscarriage, labor dystocia, intrauterine growth restriction, preterm labor, placental abruption, Placenta Previa, fetal malpresentation and postpartum haemorrhage. 4,[8][9][10]12,14…”

Section: Myomas In Pregnancymentioning

confidence: 99%

“…4 The exact mechanism by which they exert obstetric complications in pregnancy is not completely understood. 8,12…”

Section: Management Controversy and Complications Of Myomasmentioning

confidence: 99%

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Navigating through the maze of caesarean myomectomy: generating evidence

Khan

Itua

2019

Int J Reprod Contracept Obstet Gynecol

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Management of myomas during pregnancy and labor is a contested subject so far. Currently no recommended national or international guidelines are in place resulting in conflicted opinion and management variation across the globe. Many obstetricians still discourage its practice due to fear of uncontrolled haemorrhage which may lead to unwanted hysterectomy in a reproductive age. However, some researchers have challenged the conventional perspective and argue that caesarean myomectomy (CM) is a safe procedure. The aim of this study is to examine all aspects of CM with an evaluative lens and to weigh its risk-benefit ratio. For this purpose, we conducted a literature review of studies, including those from low-resource countries indexed in scientific databases like PubMed, Google Scholar and Scopus. Most recent articles that reported benefits, complications and different techniques to safely perform caesarean myomectomy with proven benefit for the patient were examined thoroughly so that solid evidence on pros and cons of caesarean myomectomy could be generated. There is a dire need to conduct large sample size studies or randomized controlled trials for the risk-benefit evaluation of CM and to produce evidence-based clinical conclusion.

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Myomectomy During Cesarean Section: Why Do We Abstain From?

Güler

Kıncı

et al. 2020

J Obstet Gynecol India

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Cesarean myomectomy for solitary uterine fibroids: Is it a safe procedure?

Cited by 17 publications

References 0 publications

The −2549 insertion/deletion polymorphism of VEGF gene associated with uterine leiomyoma susceptibility in women from Southeastern Iran

The −2549 insertion/deletion polymorphism of VEGF gene associated with uterine leiomyoma susceptibility in women from Southeastern Iran

Navigating through the maze of caesarean myomectomy: generating evidence

Myomectomy During Cesarean Section: Why Do We Abstain From?

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