Cervicovaginal washing prolactin assay in prediction of preterm delivery

Leylek, O.A.; Songur, Selda; Erselcan, Taner; Çetin, Ali; Izgiç, Ertan

doi:10.1016/s0020-7292(97)00121-5

Cited by 6 publications

(12 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There were five primary studies, two evaluating the test in a population of asymptomatic women (n = 80) 137,138 and five evaluating the test in symptomatic women (n = 265), [137][138][139][140][141] presenting with threatened preterm labour, including two studies that evaluated the test in both populations. 137,138 The study enrolment ranged from 35 women 138 to 66 women.…”

Section: Study Characteristics and Qualitymentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

185

146

View full text Add to dashboard Cite

For primary prevention, an effective, affordable and safe intervention applied to all mothers without preceding testing is likely to be the most cost-effective approach in asymptomatic women in early pregnancy. For secondary prevention among women at risk of preterm labour in later pregnancy, a management strategy based on the results of testing is likely to be more cost-effective. Implementation of a treat-all strategy with simple interventions, such as fish oils, would be premature for asymptomatic women. Universal provision of high-quality ultrasound machines in labour wards is more strongly indicated for predicting spontaneous preterm birth among symptomatic women than direct management, although staffing issues and the feasibility and acceptability to mothers and health providers of such strategies need to be explored. Further research should include investigations of low-cost and effective tests and treatments to reduce and delay spontaneous preterm birth and reduce the risk of perinatal mortality arising from preterm birth.

show abstract

Section: Study Characteristics and Qualitymentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

185

146

View full text Add to dashboard Cite

show abstract

“…9 Existen cinco estudios previos que determinaron las concentraciones de prolactina en secreción cervicovaginal, tanto en embarazadas sintomáticas como asintomáticas. 12,[17][18][19][20] Hasta el momento la presente investigación es la que mayor cantidad de pacientes ha seleccionado, ya que en los estudios previos 66 fue el mayor tamaño muestral. 20 En comparación con esos estudios, la presente investigación demostró que un valor de corte de 1 ng/mL fue útil para la predicción del parto en embarazadas asintomáticas durante el segundo trimestre que posteriormente presentaron parto pretérmino.…”

Section: I S C U S I ó Nunclassified

“…12,[17][18][19][20] Hasta el momento la presente investigación es la que mayor cantidad de pacientes ha seleccionado, ya que en los estudios previos 66 fue el mayor tamaño muestral. 20 En comparación con esos estudios, la presente investigación demostró que un valor de corte de 1 ng/mL fue útil para la predicción del parto en embarazadas asintomáticas durante el segundo trimestre que posteriormente presentaron parto pretérmino. Este valor es inferior a lo reportado previamente por O´Brien y col 12 quienes consideraron que valores superiores de 2 ng/mL eran positivos.…”

Section: I S C U S I ó Nunclassified

“…De igual manera, este valor de corte también es menor al reportado en esas otras investigaciones previas, en las que se identificaron cifras de corte de 1,5 ng/mL, 1,8 ng/mL y 50 ng/ mL. 17,19,20 En esta investigación, la sensibilidad de las concentraciones cervicovaginales de prolactina para la predicción de parto pretérmino fue 73%, mayor que el 61% publicado antes por O´Brien y col.…”

Section: I S C U S I ó Nunclassified

“…12,20 Los valores de ambas razones de probabilidad en esta investigación están incluidos dentro del rango de esas investigaciones.…”

Section: I S C U S I ó Nunclassified

See 2 more Smart Citations

Prolactina cervicovaginal en la predicción de parto pretérmino

et al. 2018

View full text Add to dashboard Cite

Objetivo: establecer la utilidad de las concentraciones cervicovaginales de prolactina en el segundo trimestre para la predicción del parto pretérmino. Métodos: las muestras cervicovaginales se tomaron entre 24 y 28 semanas de embarazo. Todos los embarazos fueron seguidos hasta el parto y divididos en grupos A (parto pretérmino) y B (parto a término). Se evaluaron las características generales, concentraciones séricas de prolactina y eficacia pronóstica. Resultados: la edad gestacional al momento de la determinación de la toma de muestra cervicovaginal fue de 26,2 +/- 1,1 semanas para el grupo A y 25,9 +/- 1,1 semanas para el B (p = ns). No se encontraron diferencias estadísticamente significativas en la edad materna, índice de masa corporal y antecedentes de parto pretérmino (p = ns). Las pacientes del grupo A (1,6 +/- 0,8 ng/mL) presentaron concentraciones cervicovaginales significativas más altas de prolactina comparadas con las del grupo B (0,5 +/- 0,3 ng/mL; p < 0,0001). Un valor de corte de 1 ng/mL presentó un valor por debajo de la curva de 0,87 con sensibilidad 73,1%, especificidad 91,6%, valor predictivo positivo 44,7% y valor predictivo negativo 97,3%. Conclusión: las concentraciones cervicovaginales de prolactina son útiles en la predicción del parto pretérmino.

show abstract

Early pregnancy peripheral blood gene expression and risk of preterm delivery: a nested case control study

Enquobahrie

Williams

Qiu

et al. 2009

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

BackgroundPreterm delivery (PTD) is a significant public health problem associated with greater risk of mortality and morbidity in infants and mothers. Pathophysiologic processes that may lead to PTD start early in pregnancy. We investigated early pregnancy peripheral blood global gene expression and PTD risk.MethodsAs part of a prospective study, ribonucleic acid was extracted from blood samples (collected at 16 weeks gestational age) from 14 women who had PTD (cases) and 16 women who delivered at term (controls). Gene expressions were measured using the GeneChip® Human Genome U133 Plus 2.0 Array. Student's T-test and fold change analysis were used to identify differentially expressed genes. We used hierarchical clustering and principle components analysis to characterize signature gene expression patterns among cases and controls. Pathway and promoter sequence analyses were used to investigate functions and functional relationships as well as regulatory regions of differentially expressed genes.ResultsA total of 209 genes, including potential candidate genes (e.g. PTGDS, prostaglandin D2 synthase 21 kDa), were differentially expressed. A set of these genes achieved accurate pre-diagnostic separation of cases and controls. These genes participate in functions related to immune system and inflammation, organ development, metabolism (lipid, carbohydrate and amino acid) and cell signaling. Binding sites of putative transcription factors such as EGR1 (early growth response 1), TFAP2A (transcription factor AP2A), Sp1 (specificity protein 1) and Sp3 (specificity protein 3) were over represented in promoter regions of differentially expressed genes. Real-time PCR confirmed microarray expression measurements of selected genes.ConclusionsPTD is associated with maternal early pregnancy peripheral blood gene expression changes. Maternal early pregnancy peripheral blood gene expression patterns may be useful for better understanding of PTD pathophysiology and PTD risk prediction.

show abstract

Cervicovaginal washing prolactin assay in prediction of preterm delivery

Cited by 6 publications

References 16 publications

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Prolactina cervicovaginal en la predicción de parto pretérmino

Early pregnancy peripheral blood gene expression and risk of preterm delivery: a nested case control study

Contact Info

Product

Resources

About