Cervico-facial adenoid cystic carcinoma: Study of 102 cases. Influence of radiation therapy

Miglianico, Laurent; Eschwège, F.; Marandas, P.; Wibault, P.

doi:10.1016/0360-3016(87)90284-7

Cited by 133 publications

(90 citation statements)

References 15 publications

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“…Moreover, 14-3-3 s was induced in normal salivary glands by irradiation, while 14-3-3 s was not induced in ACCY cells. Although the affect of factors other than 14-3-3 s could be considered, this fragility to the irradiation in ACC cells is in agreement with the clinical observations described previously (Simpson et al, 1984;Vikram et al, 1984;Miglianico et al, 1987;Garden et al, 1995;Parsons et al, 1996). These results indicate that DNA-damaging therapy might be more effective in cancers, such as ACC, with hypermethylation of 14-3-3 s gene than in cancers, such as MEC, without hypermethylation of 14-3-3 s gene.…”

Section: -3-supporting

confidence: 90%

“…However, the radiosensitivity is reported to be quite different in ACC and MEC. Combination radical surgery with radiotherapy in ACC has led to superior results in many studies (Simpson et al, 1984;Vikram et al, 1984;Miglianico et al, 1987;Garden et al, 1995;Parsons et al, 1996), but in MEC such combination treatment is generally less effective (Nascimento et al, 1986;Grenman et al, 1992). These findings suggest that cell cyclerelated gene(s) at the G2 checkpoint might play important roles in the difference in radiosensitivity between these cancers, since the G2-residing cells are normally more sensitive to irradiation.…”

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confidence: 99%

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Frequent downregulation of 14-3-3 σ protein and hypermethylation of 14-3-3 σ gene in salivary gland adenoid cystic carcinoma

Uchida

Almofti

et al. 2004

Br J Cancer

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14-3-3 σ , a target gene of the p53 tumour suppressor protein, has been shown to regulate the cell cycle at the G2/M checkpoint. Recent studies have demonstrated that 14-3-3 σ is downregulated by hypermethylation of the CpG island in several types of cancer. In this study, we investigated the expression and methylation status of 14-3-3 σ in human salivary gland adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC). Immunohistochemical analysis revealed that the positive expression rate of 14-3-3 σ in ACC (one out of 14) was markedly lower than that in MEC (ten out of 10). Since most of the ACCs carried the wild-type p53 protein, downregulation of 14-3-3 σ in ACC may not be due to the dysfunction of p53 pathway. Microdissection–methylation-specific PCR revealed that frequent hypermethylation of the 14-3-3 σ gene was observed in ACC when compared to that in MEC. In cultured-ACC cells, we confirmed the downregulation of 14-3-3 σ via hemimethylation of the gene by sequencing analysis after sodium bisulphite treatment. Furthermore, re-expression of 14-3-3 σ in the ACC cells was induced by the treatment with DNA demethylating agent, 5-aza-2′-deoxycytidine. Irradiation apparently induced the enhanced expression of 14-3-3 σ and G2/M arrest in normal salivary gland cells; however, in the ACC cells, neither induction of 14-3-3 σ nor G2/M arrest was induced by irradiation. These results suggest that downregulation of 14-3-3 σ might play critical roles in the neoplastic development and radiosensitivity of ACC.

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Section: -3-supporting

confidence: 90%

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confidence: 99%

Frequent downregulation of 14-3-3 σ protein and hypermethylation of 14-3-3 σ gene in salivary gland adenoid cystic carcinoma

Uchida

Almofti

et al. 2004

Br J Cancer

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“…Although data from randomized trials is lacking, most practitioners consider such treatment to be beneficial 42, 51, 52. In 1 retrospective study, the 5‐year local control rate for patients treated with surgery followed by radiation therapy was 78% compared to 44% for those treated with surgery alone 53. In another report, 10‐year local control rates were 83% and 25% for patients who had surgery with or without postoperative radiation, respectively 54.…”

Section: Introductionmentioning

confidence: 99%

Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials

Chakraborty²,

et al. 2015

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BackgroundAdenoid cystic carcinoma (ACC) is a rare tumor of secretory glands. In this study, recent advances in molecular characterization and in therapeutics are reviewed.MethodsA search of articles in PubMed and of abstracts from national meetings was performed regarding ACC.ResultsRecent genetic analyses found that recurrent chromosome 6:9 translocations in ACC generate an MYB:NFIB gene fusion resulting in overexpression of the MYB oncoprotein. Several other frequent mutations are recently published that may be relevant for drug development. Several trials of targeted drugs are reviewed. Some agents delay tumor progression, but tumor responses remain rare.ConclusionACCs have a characteristic chromosomal translocation, but also frequently pick up additional mutations. Clinical research is limited by the rarity and slow growth of ACC. Several ongoing trials are testing agents that inhibit fibroblast growth factor receptor signaling or other signaling pathways. Novel treatments based on the recently sequenced tumor genome are under development. © 2015 The Authors Head & Neck Published by Wiley Periodicals, Inc. 38: 620–627, 2016

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“…The natural history of adenoid cystic carcinoma is characterized by an indolent growth rate, 1,6 a relatively low probability of regional lymph node metastases, 5 -8 and a high likelihood of hematogenous dissemination. 1,9 The most common site of distant metastases is the lung.…”

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confidence: 99%

“…1,9 The most common site of distant metastases is the lung. 3, 10 Miglianico et al 6 at the Institut Gustave Roussy ( Villejuif, France) reported a 38% 5-year survival rate after the diagnosis of distant metastases; two patients lived longer than 10 years.…”

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confidence: 99%

Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck

et al. 2004

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Background. The purpose of this study was to analyze the results of radiotherapy (RT) alone or combined with surgery for adenoid cystic carcinoma.Methods. Between September 1966 and November 2001, 101 previously untreated patients were treated with curative intent with RT alone or combined with surgery. Follow-up ranged from 0.4 to 30.6 years (median, 6.6 years). All living patients had follow-up for at least 1 year.Results. The 5-and 10-year rates of local control were as follows: RT alone, 56% and 43%; surgery and RT, 94% and 91%; and overall, 77% and 69%. Multivariate analysis of local control revealed that T stage ( p = .0101) and treatment group ( p = .0008) significantly influenced this endpoint. The 5-and 10-year rates of distant metastases-free survival were 80% and 73%. The 5-and 10-year absolute survival rates were as follows: RT alone, 57% and 42%; surgery and RT, 77% and 55%; and overall, 68% and 49%. Multivariate analysis of absolute survival revealed that T stage ( p = .0043) and clinical nerve invasion ( p = .0011) significantly influenced this endpoint. The 5-and 10-year causespecific survival rates were as follows: RT alone, 65% and 48%; surgery and RT, 81% and 71%; and overall, 74% and 61%. Multivariate analysis revealed that T stage ( p = .0008) and clinical nerve invasion ( p = .0005) significantly influenced causespecific survival.Conclusions. The optimal treatment for patients with adenoid cystic carcinoma is surgery and adjuvant RT. A significant proportion of patients with incompletely resectable disease are cured after RT alone. Improvements in locoregional control are offset, in part, by the relatively high incidence of distant metastases.

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Cervico-facial adenoid cystic carcinoma: Study of 102 cases. Influence of radiation therapy

Cited by 133 publications

References 15 publications

Frequent downregulation of 14-3-3 σ protein and hypermethylation of 14-3-3 σ gene in salivary gland adenoid cystic carcinoma

Frequent downregulation of 14-3-3 σ protein and hypermethylation of 14-3-3 σ gene in salivary gland adenoid cystic carcinoma

Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials

Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck

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