Cervical vagotomy increased the distal colon distention to urinary bladder inhibitory reflex in male rats

Kaddumi, Ezidin G.

doi:10.1007/s10286-015-0326-6

Cited by 3 publications

(2 citation statements)

References 27 publications

(31 reference statements)

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“…Further investigations are needed to specify the pathways responsible on the results of the present study.The effect of distal colon distention (DCD) on bladder function following DEI reveled that only 3 ml colon distention was able to affect the bladder function. 3 ml DCD, which is considered a nociceptive stimulus, significantly decreased the micturition frequency via increasing the storage time rather than results are consistent with results of previous studies(Kaddumi 2016a). The deference in neural circuitry mediating the effects of DEI and DCD may explain the remaining effect of DCD following DEI.…”

supporting

confidence: 76%

“…It also forms the base for functional disturbance in certain visceral pathologies (Whorwell et al 1986). In our previous studies, nociceptive mechanical distention of distal colon, which is in the same pelvic territory, was able to inhibit the activity of urinary bladder (Kaddumi 2016a). Whereas, the nociceptive mechanical distention of the distal esophagus, which is in the vagal territory, was able to excite the activity of urinary bladder (Kaddumi et al 2012).…”

Section: Introductionmentioning

confidence: 88%

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Effect of distal esophageal irritation on the changes of cystometry parameters to esophagus and colon distentions in rats

Kaddumi

2019

Can. J. Physiol. Pharmacol.

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The coexistence of different visceral pathologies in patients suffering from irritable bowel syndrome, interstitial cystitis, and other pathologies, necessitates the study of these pathologies under complicated conditions. In the present study, cystometry recordings were used to investigate the effect of distal esophageal chemical irritation on the urinary bladder interaction with distal colon distention, distal esophageal distention, and electrical stimulation of abdominal branches of vagus nerve. Distal esophageal chemical irritation significantly decreased the intercontraction time via decreasing the voiding time. Also, distal esophageal chemical irritation significantly decreased the pressure amplitude by decreasing the maximum pressure. Following distal esophageal chemical irritation, distal esophageal distention was able to significantly decrease the intercontraction time by decreasing the storage time. However, 3 mL distal colon distention significantly increased the intercontraction time by increasing the storage time. On the other hand, following distal esophageal chemical irritation, electrical stimulation of abdominal branches of vagus nerve did not have any significant effect on intercontraction time. However, electrical stimulation of abdominal branches of vagus nerve significantly increased the pressure amplitude by increasing the maximum pressure. The results of this study demonstrate that urinary bladder function and interaction of bladder with other viscera can be affected by chemical irritation of distal esophagus.

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supporting

confidence: 76%

Section: Introductionmentioning

confidence: 88%

Effect of distal esophageal irritation on the changes of cystometry parameters to esophagus and colon distentions in rats

Kaddumi

2019

Can. J. Physiol. Pharmacol.

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Vagal afferent responses to cystometry in rat models of urinary bladder irritation: c-fos immunohistochemistry study

Kaddumi,

Fararjeh,

Udwan

2023

Int Urol Nephrol

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Effect of low-threshold versus high-threshold genitalia stimuli on the cystometry parameters in male rats

Kaddumi

Khader

Tahaineh

2021

American Journal of Physiology-Regulatory, Integrative and Comp

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The cross talk between external genitalia and urinary bladder could be utilized as part of management to certain pathological conditions affecting urinary bladder. Since urinary bladder function is also affected by pathologies of other organs (e.g., colon and esophagus), the effect of genitalia stimuli on parameters of bladder function in normal or under different pathological conditions needs to be characterized. Cystometry recordings in male rats were used to examine the effect of low threshold (LT) and high threshold (HT) stimulation of the scrotum and penis on urinary bladder function. These effects were studied in intact, colon irritation (CI), and esophagus irritation (EI) groups. Although, HT penile stimulation had a significant inhibitory effect on micturition reflex in all groups, CI hypersensitized the penile-bladder inhibitory reflex. In addition, LT penile stimulation had a significant inhibitory effect on micturition, which was significant in CI group, only. On the other hand, HT penile stimulation, in CI group, significantly increased the timing parameters of cystometry. While, LT and HT penile stimuli, in EI group, had a significantly increasing effect on all pressure parameters of cystometry. The scrotal stimuli had minimal effect on bladder function in all groups except for HT scrotal stimulation in the CI group, where it had a significant inhibitory effect on micturition reflex and significantly increased the maximum pressure and pressure amplitude of micturition cycles. These results show that CI and EI exacerbate the effects of genitalia stimuli, especially penile stimuli, on urinary bladder function.

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Cervical vagotomy increased the distal colon distention to urinary bladder inhibitory reflex in male rats

Abstract: These results demonstrate the presence of supraspinal inhibitory regulation, via the vagus nerve, over the distal colon to urinary bladder inhibitory reflex.

Cited by 3 publications

References 27 publications

Effect of distal esophageal irritation on the changes of cystometry parameters to esophagus and colon distentions in rats

Effect of distal esophageal irritation on the changes of cystometry parameters to esophagus and colon distentions in rats

Vagal afferent responses to cystometry in rat models of urinary bladder irritation: c-fos immunohistochemistry study

Effect of low-threshold versus high-threshold genitalia stimuli on the cystometry parameters in male rats

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