Cervical phIGFBP‐1 in the evaluation of the risk of preterm delivery

Paternoster, Delia Maria; Muresan, Dana; Vitulo, Anna; Serena, A.; Battagliarin, G.; Dell'Avanzo, M.; Nicolini, Umberto

doi:10.1080/00016340600935730

Cited by 36 publications

(29 citation statements)

References 24 publications

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“…Kekki et al [17] also discussed the high negative predictive value of determining IGFBP-1, and Bittar [18] also tested pregnant women without symptoms of preterm delivery and found that the sensitivity of the test was 83%, positive predictive value 63%, specificity 80%, and negative predictive value 92%. Similar results of high specificity and negative predictive value in asymptomatic pregnant women were shown in other studies published last year [19,20,21,22].…”

Section: Discussionsupporting

confidence: 91%

Insulin-like growth factor-binding protein-1 (IGFBP-1) in cervical secretions as a predictor of preterm delivery

Balić

Latifagić

Hudić

2008

The Journal of Maternal-Fetal & Neonatal Medicine

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Section: Discussionsupporting

confidence: 91%

Insulin-like growth factor-binding protein-1 (IGFBP-1) in cervical secretions as a predictor of preterm delivery

Balić

Latifagić

Hudić

2008

The Journal of Maternal-Fetal & Neonatal Medicine

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“…146,150 Otherwise all studies used cohorts of pregnant women; all except two 151,152 reported prospective data collection design and, with one exception, 151 had provided adequate test description. The methodological quality of the included primary studies is summarised in Figure 18.…”

Section: Study Characteristics and Qualitymentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

185

146

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For primary prevention, an effective, affordable and safe intervention applied to all mothers without preceding testing is likely to be the most cost-effective approach in asymptomatic women in early pregnancy. For secondary prevention among women at risk of preterm labour in later pregnancy, a management strategy based on the results of testing is likely to be more cost-effective. Implementation of a treat-all strategy with simple interventions, such as fish oils, would be premature for asymptomatic women. Universal provision of high-quality ultrasound machines in labour wards is more strongly indicated for predicting spontaneous preterm birth among symptomatic women than direct management, although staffing issues and the feasibility and acceptability to mothers and health providers of such strategies need to be explored. Further research should include investigations of low-cost and effective tests and treatments to reduce and delay spontaneous preterm birth and reduce the risk of perinatal mortality arising from preterm birth.

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“…Nine studies provided data on cervicovaginal phosphorylated insulin-like growth factor binding protein-1 (phI-GFBP-1), [65][66][67]69,[72][73][74]77,79 seven studies provided data on relaxin, 34,60,61,70,71,75,78 three studies provided data on cervicovaginal human chorionic gonadotrophin (hCG), 63,68,76 two studies provided data on cervicovaginal prolactin, 62,64 four studies provided data on pregnancy-associated plasma protein-A (PAPP-A), 81,84,85,87 two studies provided data on activin-A, 80,82 and one study each provided data on placental protein-13 (PP13) 83 and pregnancy-specific-b1 glycoprotein (SP1). 86 For cervicovaginal levels of hCG, phIGFBP-1, and prolactin, the pooled sensitivities, specificities, positive and negative LRs to predict preterm birth before 32, 34, and 37 weeks of gestation ranged between 33 and 83% (median, 67%), 62 and 97% (median, 79%), 1.6 and 19.0 (median, 3.2), and 0.2 and 0.8 (median, 0.5), respectively (Table 1).…”

Section: Placental Protein/hormone-related Biomarkersmentioning

confidence: 99%

Novel biomarkers for the prediction of the spontaneous preterm birth phenotype: a systematic review and meta-analysis

Conde-Agudelo

Papageorghiou

Kennedy

et al. 2011

BJOG: An International Journal of Obstetrics &Amp; Gynaecology

145

114

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Background Being able to predict preterm birth is important, as it may allow a high-risk population to be selected for future interventional studies and help in understanding the pathways that lead to preterm birth.Objective To investigate the accuracy of novel biomarkers to predict spontaneous preterm birth in women with singleton pregnancies and no symptoms of preterm labour.Search strategy Electronic searches in PubMed, Embase, Cinahl, Lilacs, and Medion, references of retrieved articles, and conference proceedings. No language restrictions were applied.Selection criteria Observational studies that evaluated the accuracy of biomarkers proposed in the last decade to predict spontaneous preterm birth in asymptomatic women. We excluded studies in which biomarkers were evaluated in women with preterm labour.Data collection and analysis Two reviewers independently extracted data on study characteristics, quality, and accuracy. Data were arranged in 2 · 2 contingency tables and synthesised separately for spontaneous preterm birth before 32, 34, and 37 weeks of gestation. We used bivariate meta-analysis to estimate pooled sensitivities and specificities, and calculated likelihood ratios (LRs).Main results A total of 72 studies, including 89 786 women and evaluating 30 novel biomarkers, met the inclusion criteria. Only three biomarkers (proteome profile and prolactin in cervicovaginal fluid, and matrix metalloproteinase-8 in amniotic fluid) had positive LRs > 10. However, each of these biomarkers was evaluated in only one small study. Four biomarkers had a moderate predictive accuracy (interleukin-6 and angiogenin, in amniotic fluid; human chorionic gonadotrophin and phosphorylated insulin-like growth factor binding protein-1, in cervicovaginal fluid). The remaining biomarkers had low predictive accuracies.Conclusions None of the biomarkers evaluated in this review meet the criteria to be considered a clinically useful test to predict spontaneous preterm birth. Further large, prospective cohort studies are needed to evaluate promising biomarkers such as a proteome profile in cervicovaginal fluid.

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Cervical phIGFBP‐1 in the evaluation of the risk of preterm delivery

Cited by 36 publications

References 24 publications

Insulin-like growth factor-binding protein-1 (IGFBP-1) in cervical secretions as a predictor of preterm delivery

Insulin-like growth factor-binding protein-1 (IGFBP-1) in cervical secretions as a predictor of preterm delivery

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Novel biomarkers for the prediction of the spontaneous preterm birth phenotype: a systematic review and meta-analysis

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