Cervical microRNA expression and spontaneous preterm birth

Burris, Heather H.; Gerson, Kristin D.; Woodward, Alexa; Redhunt, Allyson M.; Ledyard, Rachel; Brennan, Kasey; Baccarelli, Andrea A.; Collier, Ai‐ris Y.; Hacker, Michele R.

doi:10.1016/j.ajogmf.2022.100783

Cited by 10 publications

(5 citation statements)

References 42 publications

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“…Burris et al addressed the challenge of predicting spontaneous preterm birth, identifying a subset of upregulated microRNAs associated with subsequent spontaneous preterm birth. This study emphasizes the potential of microRNA expression as a predictive biomarker, with implications for reducing infant morbidity and mortality [43].…”

Section: Resultsmentioning

confidence: 94%

MicroRNA Associations with Preterm Labor—A Systematic Review

Kondracka,

Stupak,

Rybak-Krzyszkowska

et al. 2024

IJMS

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This systematic review delves into the connections between microRNAs and preterm labor, with a focus on identifying diagnostic and prognostic markers for this crucial pregnancy complication. Covering studies disseminated from 2018 to 2023, the review integrates discoveries from diverse pregnancy-related scenarios, encompassing gestational diabetes, hypertensive disorders and pregnancy loss. Through meticulous search strategies and rigorous quality assessments, 47 relevant studies were incorporated. The synthesis highlights the transformative potential of microRNAs as valuable diagnostic tools, offering promising avenues for early intervention. Notably, specific miRNAs demonstrate robust predictive capabilities. In conclusion, this comprehensive analysis lays the foundation for subsequent research, intervention strategies and improved outcomes in the realm of preterm labor.

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Section: Resultsmentioning

confidence: 94%

MicroRNA Associations with Preterm Labor—A Systematic Review

Kondracka,

Stupak,

Rybak-Krzyszkowska

et al. 2024

IJMS

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“…It was documented that lead exposure caused abnormal birth outcomes during pregnancy. [ 13 14 ] Uniquely, biological changes during pregnancy can make people more sensitive to toxic exposures. Through the air, food, water, and consumer goods, pregnant women are exposed to a variety of environmental toxins, including pesticides, plasticizers, and flame retardants.…”

Section: Discussionmentioning

confidence: 99%

Blood lead levels in pregnant women and their newborn infants at an Indian teaching hospital

Sahu,

Yogeshbhai,

Oza

et al. 2024

Journal of Family Medicine and Primary Care

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Background and Aim: With the growth of the world’s economy and industrialization, lead (Pb) contamination in the environment has become a major issue on a global scale. Lead is typically linked to unfavorable pregnancy outcomes such as stillbirth, low birth weight preterm, and spontaneous abortion. In this study, we evaluated the blood lead levels of pregnant women and their birth outcomes attending an Indian tertiary care teaching hospital, those who were not exposed to any lead-associated industry or shops. Methods: A descriptive study was undertaken to evaluate blood lead estimation in pregnant women and umbilical blood lead levels in a community hospital. Blood samples from 104 mothers during the 1st trimester, 90 mothers during 3rd trimester, and from the umbilical cord were collected. Self-administered questionnaires were used to collect information on demographics, medical history, and concerns linked to pregnancy. Following acid digestion, the levels of lead in whole blood were determined by an atomic absorption spectrometer. The DNA damage in high blood lead-concentrated pregnant women was evaluated by comet assay methods. Results: Among 194 blood samples of pregnant women, 31 (15.98%) samples revealed ≥5 μg/dL blood lead levels. High lead concentration (≥5 µg/dL) in 1st trimester pregnant women, end of 3rd trimester and cord blood were detected 20.19%, 11.11% and 1.11% respectively. The mean blood lead levels in 1st trimester, 3rd trimester, and cord blood were 3.88 ± 3.19, 2.66 ± 1.82, and 1.53 ± 1.06 mg/dL, respectively. The blood lead concentrations were significantly higher in the 1st trimester of pregnancy than in the 3rd trimester of pregnancy (P < 0.0017). A positive correlation between maternal and infant blood lead levels was revealed (P < 0.0001). When the comet assay was used to assess the genotoxic consequences of elevated blood lead levels during pregnancy, higher amounts of DNA damage were found in the samples (P < 0.01). Conclusion: In this descriptive study, there was a significant amount of lead transferred from mother to baby through the placenta. All mothers were not exposed to lead-associated industry and most were housewives. This article may be viewed as an eye-opener for understanding the blood lead concentration during pregnancy to avoid abnormal birth outcomes. To minimize exposure to environmental lead, all possible measures should be undertaken.

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“…38 Many miRNAs are aberrantly expressed in PTB pregnancies, including miR-18a-3p, miR-222-3p, miR-494-3p, miR-98-3p, miR-224-5p, miR-760, miR-143, miR-30e-3p, miR-199b, and miR-125a-3p. [39][40][41][42] Pavlek et al reported that miR-29b was associated with perinatal inflammation in preterm infants. 43 In addition, Peng and co-workers revealed that miR-199a-3p suppressed cervical epithelial cell inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway in PTB.…”

Section: Discussionmentioning

confidence: 99%

“…MiRNAs exert a critical effect on gene expression as well as various physiological and pathological processes, due to their posttranscriptional regulation through binding to the 3′UTR of target genes 38 . Many miRNAs are aberrantly expressed in PTB pregnancies, including miR‐18a‐3p, miR‐222‐3p, miR‐494‐3p, miR‐98‐3p, miR‐224‐5p, miR‐760, miR‐143, miR‐30e‐3p, miR‐199b, and miR‐125a‐3p 39–42 . Pavlek et al reported that miR‐29b was associated with perinatal inflammation in preterm infants 43 .…”

Section: Discussionmentioning

confidence: 99%

MiRNA‐26a‐5p inhibits preterm labor initiation by targeting and regulating TRPC3 ion channel protein expression

Chen,

Liu,

Cui

et al. 2023

Environmental Toxicology

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The incidence of preterm birth (PTB) is increasing annually worldwide, leading to various health problems or even fetal deaths. Our previous work demonstrated the activation of transient receptor potential cation channel subfamily C 3 (TRPC3) in mice with PTB, and its activation could promote inward flow of calcium ions and uterine smooth muscle (USM) contraction via regulation of Cav3.2, Cav3.1, and Cav1.2. However, the upstream regulators of TRPC3 and its mechanisms remain unknown. In the present study, the binding of miR‐26a‐5p to the 3′ untranslated region of TRPC3 was predicted by bioinformatics databases (TargetScanHuman and starBase v3.0) and confirmed by a dual‐luciferase assay. MiR‐26a‐5p was downregulated, while TRPC3 was upregulated in the USM tissues of patients with PTB compared to people without PTB. The results showed that miR‐26a‐5p mimic transfection markedly reduced TRPC3 expression in LPS‐stimulated USM cells. Additionally, miR‐26a‐5p regulated intracellular Ca2+ levels in USM cells by targeting TRPC3. Furthermore, miR‐26a‐5p inhibited the CPI17/PKC/PLCγ signaling pathway and reduced the expression of Cav3.2, Cav3.1, and Cav1.2. In conclusion, miR‐26a‐5p regulated the initiation of PTB by targeting TRPC3 and regulating intracellular Ca2+ levels. This study provides a promising diagnostic biomarker and therapeutic target for PTB.

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Cervical microRNA expression and spontaneous preterm birth

Cited by 10 publications

References 42 publications

MicroRNA Associations with Preterm Labor—A Systematic Review

MicroRNA Associations with Preterm Labor—A Systematic Review

Blood lead levels in pregnant women and their newborn infants at an Indian teaching hospital

MiRNA‐26a‐5p inhibits preterm labor initiation by targeting and regulating TRPC3 ion channel protein expression

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