Cervical Lymph Node Metastases in Thoracic Esophageal Cancer and Their Prognostic Role

Yoshioka, Masakazu; Okuma, Toshitada; Kaneko, Hirofumi; Torigoe, Yoshitsugu; Miyauchi, Yoshimasa

doi:10.1007/978-4-431-68246-2_91

Cited by 1 publication

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“…For the tumors of mid‐thoracic esophagus, the metastasis is located in the cervical region (28.6%), upper mediastinum (33%), subcarinal (34%) or cardia (37%) 24,25 . The incidence of cervical lymph node metastasis for lower esophageal carcinoma is 28% 5,8,10,25–28 Table 3. describes the distribution of lymphatic spread in thoracic esophageal tumors.…”

Section: Discussionmentioning

confidence: 99%

Three-field lymph node dissection in the treatment of thoracic esophageal carcinoma: the Turkish experience

Ferahköşe

Anadol

Gökbayir

et al. 2006

Diseases of the Esophagus

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The role of extended lymphatic dissection on the prognosis and outcome of thoracic esophageal carcinoma is still controversial. The aim of this study was to determine the impact of three-field lymphatic dissection on the survival and recurrence rates of patients with thoracic carcinoma of the esophagus. Forty-six patients with primary squamous cell carcinoma of the thoracic esophagus underwent esophagectomy with three-field lymphatic dissection between 1992 and 2003. Recurrence and survival rates were examined as well as complications. Overall survival for the patients was 45.6 months and 5-year survival rate was 56%. Five-year survival rates for patients with Stage 2A, 2B, 3 and 4 were 68%, 0%, 53% and 33%, respectively. There was no Stage 1 patient. Mean disease-free survival was 41.4 months. Sixty three percent of patients had node-negative disease (5-year survival rate, 68.9%) and 37% had nodal metastases (5-year survival rate, 33.7%) (P = 0.002). Surgical morbidity was seen in 35 patients (76.1%). Conclusively, lymph node involvement in patients with thoracic esophageal carcinoma is the major determinant of prognosis and survival. Extended lymphatic dissection provides higher disease-free and overall survival rates and our study revealed the highest survival rate for thoracic esophageal carcinoma, to best of our knowledge.

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Section: Discussionmentioning

confidence: 99%