Cervical Intraepithelial Neoplasia Outcomes After Large Loop Excision With Clear Margins

Cervical intraepithelial neoplasia recurrence after conization in HIV‐positive and HIV‐negative women

“…The present study found glandular involvement in 35% of patients who had recurrent CIN and in 4.3% of the nonrecurrent patients (OR 11.8; 95% CI, 3.98-36.30). In the multivariate analysis our results were similar to Paraskevadis et al [22], where glandular involvement was one of the independent risk factors associated with recurrence (HR 3.46; 95% CI: 1.71-7.01).…”

“…Nevertheless, dysplastic cells located deeper in glandular epithelium are protected from this destruction. Later, these dysplastic cells may recur, progress, or invade the surrounding stroma [3,7] Other studies showed that the most important factor related to recurrence was glandular involvement [7,22].…”

“…This difference was not significant (P = 0.09). Paraskevaidis et al [22] conducted a case-control study to identify risk factors for recurrent CIN after LEEP. Glandular involvement was found in 71% of patients who had recurrent lesions compared with 13% in the nonrecurrent patients.…”

Endocervical glandular involvement, multicentricity, and extent of the disease are features of high-grade cervical intraepithelial neoplasia

“…Results of Kır et al [5] was similar to ours, 25% endocervical glandular involvement in CIN 1 and 91% endocervical glandular involvement in CIN 3. Previously reported studies related endocervical glandular involvement to higher recurrence after LEEP [2,[8][9][10][11][12]. Opposing results were also reported [13,14].…”

Minimally Invasive Therapy of Cervical Intraepithelial Neoplasia for Fertility Preservation

“…Eighteen mm is the minimal cone length needed to prevent residual CIN III on the apex in multiparous and 15 mm in nulliparous patients. We have to emphasize that shorter cone (10-12 mm) at nulliparous may result in residual CIN III at the cone apex and obligatory reconization which may seriously disrupt the fertile function [24][25][26][27]. Since the cone apex was free from CIN in 116/124 (95%) of patients, we propose the cone length of 15 mm for women who are planning pregnancy.…”