Cervical dysplasia in Nigerian women infected with HIV

Agaba, Patricia A; Thacher, Tom D.; Cc, Ekwempu; Idoko, John

doi:10.1016/j.ijgo.2009.06.006

Cited by 38 publications

(66 citation statements)

References 22 publications

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“…The prevalence of 28.2% as found in this study is high but comparable to 27% reported in UK by Hotonu et al (2010) and 31.3% in Maiduguri, Northern Nigeria by Chama et al (2005). It is however lower than 68.3 and 43.7% prevalence rates reported in Jos, Nigeria by Agaba et al (2009) and in Kenya by Mabeya et al (2012). A lower rate of 12.6% was reported in Enugu by Dim et al (2011).…”

Section: Discussionsupporting

confidence: 60%

Sociodemographic determinants of abnormal cervical cytology among HIV positive women in Nnewi, Nigeria

Ugboaja¹,

Oguejiofor²,

Anya³

2017

Int. J. Med. Med. Sci.

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Women living with human immunodeficiency virus (HIV) infection have a higher burden of premalignant.7, p=0.03) and the Anglicans ( 2 =6.7, p=0.04). The prevalence rate was also the highest among women who were para 0-1 (36.6%), unemployed (100.0%), with no formal education (33.3%), and those who were separated from their husbands (100.0%), but these were not statistically significant. The prevalence of cervical cytological abnormalities among the HIV positive women attending the HIV clinic in NAUTH was high. Younger age, being a trader and Anglican Christian denomination were significantly associated with increased risk of premalignant lesions of the cervix.

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Section: Discussionsupporting

confidence: 60%

Sociodemographic determinants of abnormal cervical cytology among HIV positive women in Nnewi, Nigeria

Ugboaja¹,

Oguejiofor²,

Anya³

2017

Int. J. Med. Med. Sci.

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“…In countries where women have poor access to medical care, rates of CIN2/3 or more severe lesions could be higher. 18 HIV-infected women have a higher prevalence of HPV infection overall and high-risk HPV infection in particular. 19 We found an overall HPV prevalence of 69.2% among 494 HIV-infected women.…”

Section: Discussionmentioning

confidence: 99%

“…HPV detection by PCR was carried out in a nested-PCR system, using the primers MY09/11 and GP5+/6+. DNA was amplified with specific primers for HPV types 6,11,16,18,31,33 and 35, in independent reactions. Sequencing reaction of nested-PCR product was used when HPV types were not identified by the former primers.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors for cervical intraepithelial neoplasia among HIV-infected women

Teixeira¹,

Araújo²,

Corrêa³

et al. 2012

Braz J Infect Dis

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“…This was comparable to a study conducted in Cameroun which reported a prevalence of 43.5% [20], further giving credence to the fact that CIN changes are more in patients with HIV infection. Other studies conducted in Nigeria and Ethiopia, however, showed lower prevalence rates [21,22]. The difference in the prevalence rates may be due to the use of cytological smears for the diagnosis of CIN as opposed to histologically confirmed lesions used in this study.…”

Section: Discussionmentioning

confidence: 58%

Cervical Cytology or Colposcopy in the Identification of Cervical Intraepithelial Neoplastic Changes in Human Immunodeficiency Virus Positive Patients in an African Population?

Nyengidiki

Bassey

Sapira-Odu

et al. 2017

Indian J Gynecol Oncolog

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Background Effective screening methods for early detection of cervical premalignant lesions among women with human immunodeficiency virus are needful since cervical cancer is one of the AIDS-defining malignancies. Aim To determine whether cervical cytology is superior to colposcopy as screening test among women infected with human immunodeficiency virus. Method A cross-sectional study was conducted at the cancer screening centre of the University of Port Harcourt Teaching Hospital from June to August 2015. Ninety-one women attending the infectious disease clinic were recruited. A pre-structured questionnaire was used to obtain information on sociodemographic characteristics. Cervical cytology, colposcopy and colposcopically directed biopsy were carried out on each patient. The data collated analysed, validity determined, and the degree of agreement of the two test screening methods was determined using Kappa statistical analysis. Results The mean age of the respondents was 36.92 ± 6.68 years with age range of 20-58 years. Among the 91 subjects analysed, the prevalence of cervical intraepithelial neoplasia was 40.7% from histological analysis. The sensitivity, specificity, positive predictive value and negative predictive value cytology were 21.62, 79.63, 42.11 and 59.72% while colposcopy had 72.97, 57.41, 54.0 and 75.61%, respectively. The Kappa value for cytology (j = 0.014; p value = 0.885) as against that for colposcopy (j = 0.288; p value = 0.004). Conclusion The prevalence of cervical intraepithelial neoplasia among HIV-positive women was high. Colposcopy is superior to the traditional cervical cytology as screening test for the identification of cervical intraepithelial neoplastic changes in acquired immunodeficiencypositive patients in Nigeria. There is fair degree of agreement of colposcopy with histological diagnosis among these patients.

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Cervical dysplasia in Nigerian women infected with HIV

Abstract: A high prevalence of cervical dysplasia was found among HIV-positive Nigerian women, which was associated with increased immune suppression.

Cited by 38 publications

References 22 publications

Sociodemographic determinants of abnormal cervical cytology among HIV positive women in Nnewi, Nigeria

Sociodemographic determinants of abnormal cervical cytology among HIV positive women in Nnewi, Nigeria

Prevalence and risk factors for cervical intraepithelial neoplasia among HIV-infected women

Cervical Cytology or Colposcopy in the Identification of Cervical Intraepithelial Neoplastic Changes in Human Immunodeficiency Virus Positive Patients in an African Population?

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