Cervical Dysplasia and Associated Risk Factors in a Juvenile Detainee Population

Gander, Sarah; Scholten, Vicki; Osswald, I.; Sutton, Madeline Y.; Wylick, Richard van

doi:10.1016/j.jpag.2009.01.070

Cited by 24 publications

(22 citation statements)

References 29 publications

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“…T. vaginalis has also emerged as an important cofactor in amplifying the spread of human immunodeficiency virus (HIV) as individuals infected with this parasite have a significantly increased incidence of virus transmission (5,6). Additionally, chronic infection may increase the risk of cervical and aggressive prostate cancer (7)(8)(9)(10). Despite these serious consequences, the underlying biochemical processes that lead to T. vaginalis pathogenesis are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Protein Palmitoylation Plays an Important Role in Trichomonas vaginalis Adherence

Nievas

Vashisht

Corvi

et al. 2018

Molecular & Cellular Proteomics

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Section: Introductionmentioning

confidence: 99%

Protein Palmitoylation Plays an Important Role in Trichomonas vaginalis Adherence

Nievas

Vashisht

Corvi

et al. 2018

Molecular & Cellular Proteomics

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“…Asymptomatic infection by T. vaginalis is common; however, numerous symptoms and pathologies occur in both men and women, including vaginitis, urethritis, prostatitis, low‐birth‐weight infants and preterm delivery, premature rupture of membranes, and infertility (Fichorova, ; Swygard et al, ). T. vaginalis has also emerged as an important cofactor in amplifying human immunodeficiency virus spread (McClelland et al, ; Van Der Pol et al, ) and increasing the risk of cervical and prostate cancers (Gander, Scholten, Osswald, Sutton, & van Wylick, ; Stark et al, ; Sutcliffe et al, ; Twu et al, ).…”

Section: Introductionmentioning

confidence: 99%

Epigenetics regulates transcription and pathogenesis in the parasiteTrichomonas vaginalis

Pachano

Nievas

Lizarraga

et al. 2017

Cellular Microbiology

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Trichomonas vaginalis is a common sexually transmitted parasite that colonizes the human urogenital tract. Infections range from asymptomatic to highly inflammatory, depending on the host and the parasite strain. Different T. vaginalis strains vary greatly in their adherence and cytolytic capacities. These phenotypic differences might be attributed to differentially expressed genes as a consequence of extra-genetic variation, such as epigenetic modifications. In this study, we explored the role of histone acetylation in regulating gene transcription and pathogenesis in T. vaginalis. Here, we show that histone 3 lysine acetylation (H3KAc) is enriched in nucleosomes positioned around the transcription start site of active genes (BAP1 and BAP2) in a highly adherent parasite strain; compared with the low acetylation abundance in contrast to that observed in a less-adherent strain that expresses these genes at low levels. Additionally, exposition of less-adherent strain with a specific histone deacetylases inhibitor, trichostatin A, upregulated the transcription of BAP1 and BAP2 genes in concomitance with an increase in H3KAc abundance and chromatin accessibility around their transcription start sites. Moreover, we demonstrated that the binding of initiator binding protein, the transcription factor responsible for the initiation of transcription of ~75% of known T. vaginalis genes, depends on the histone acetylation state around the metazoan-like initiator to which initiator binding protein binds. Finally, we found that trichostatin A treatment increased parasite aggregation and adherence to host cells. Our data demonstrated for the first time that H3KAc is a permissive histone modification that functions to mediate both transcription and pathogenesis of the parasite T. vaginalis.

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“…5 In Canada, girls in juvenile detention had higher rates of abnormal Papanicolou (Pap) tests than the general adolescent female population. 6 Given these higher risks to incarcerated girls and women, a California study demonstrated that women frequently have had Pap testing in jails and prison and are willing to have Pap testing in correctional settings, 7 so opportunities exist to intervene in criminal justice settings.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Cervical Cancer in Criminal Justice Settings

Binswanger

Mueller²,

Clark³

et al. 2011

Journal of Women's Health

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Background: Women in criminal justice settings have an increased prevalence of cervical cancer compared with the general population. However, little is known about abnormal cervical cancer screening results among women in jail and community-based criminal justice settings. Thus, the aims of this study were to compare the prevalence of self-reported abnormal Papanicolou (Pap) test results in women in jail and under community criminal justice supervision and to examine factors associated with abnormal Pap tests in these criminal justice settings. Methods: We analyzed data from two cross-sectional surveys of women in jails and community corrections in two Southern cities (n = 380) about their history of abnormal Pap tests and risk factors for cervical cancer. Univariate analyses (analysis of variance [ANOVA] and chi-square) and a binary logistic regression analysis were conducted to test associations between a history of abnormal Pap testing and factors known to be associated with cervical cancer. Results: Nearly half of the women surveyed (n = 163, 43%) reported ever having an abnormal Pap test. There was a high prevalence of risk factors for cervical cancer among women with and without an abnormal Pap test. After controlling for age and race, there were significant associations between an abnormal Pap test and inconsistent use of barrier protection (odds ratio [OR] 2.01, 95% confidence interval [CI] 1.18-3.43), having a history of gynecologic infections (OR 1.68, 95% CI 1.05-2.67), and having a history of sexually transmitted diseases (OR 1.92, 95% CI 1.17-3.15). Conclusions: Women in jail and under community justice supervision reported a high prevalence of risk factors for cervical cancer. Because of their high prevalence of abnormal Pap testing, women in criminal justice settings may be appropriate targets for improved cervical cancer screening, prevention with human papillomavirus (HPV) vaccination, risk reduction education, and treatment.

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Cervical Dysplasia and Associated Risk Factors in a Juvenile Detainee Population

Cited by 24 publications

References 29 publications

Protein Palmitoylation Plays an Important Role in Trichomonas vaginalis Adherence

Protein Palmitoylation Plays an Important Role in Trichomonas vaginalis Adherence

Epigenetics regulates transcription and pathogenesis in the parasiteTrichomonas vaginalis

Risk Factors for Cervical Cancer in Criminal Justice Settings

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