Preterm birth (PTB) remains a the leading cause of neonatal morbidity and mortality globally. 1 Although births before 37 weeks of gestation are defined as preterm, most cases of neonatal mortality and morbidity occur before 28 weeks of gestation. This occurrence is referred to as extremely preterm (EP) birth, constituting less than 1% of all births and about 5% of all PTBs.Owing to advances in perinatal technology, the current mortality rate for neonates born EP has improved. For neonates born at 28 weeks gestation, the rate of survival is approximately 90%, and the rate of survival without morbidities is higher than 50%. 2-4 Accordingly, we focus on whether the gestation period reaches 28 weeks. However, relevant mortality and morbidity can only significantly change by improving the identification of women at high risk for PTB and providing an active intervention for them. Despite continued research efforts worldwide, the ability to predict and prevent PTB is limited.