Cervical cord area is associated with infratentorial grey and white matter volume predominantly in relapsing–remitting multiple sclerosis: A study using semi-automated cord volumetry and voxel-based morphometry

Bellenberg, Barbara; Schneider, Ruth; Weiler, Florian; Suchan, Boris; Haghikia, Aiden; Hoffjan, Sabine; Gold, Ralf; Köster, O.; Lukas, Carsten

doi:10.1016/j.msard.2015.04.003

Cited by 12 publications

(13 citation statements)

References 39 publications

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“…By contrast, in MS, we found predominant correlations between cervical cord atrophy and, volume loss of BS and the CV suggesting different underlying etiopathogenesis like infratentorial atrophy and consecutive secondary degeneration. These findings were in accordance with a recent VBM study showing significant associations between UCCA atrophy and infratentorial volume loss in early MS .…”

Section: Discussionsupporting

confidence: 93%

Cervical cord and ventricle affection in neuromyelitis optica

et al. 2016

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Section: Discussionsupporting

confidence: 93%

Cervical cord and ventricle affection in neuromyelitis optica

et al. 2016

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“…This is in line with previous studies reporting similar subcortical volume changes as well as associations with clinical changes in clinical isolated syndrome (CIS) or later stages of RRMS [66–73]. The brainstem is known to be involved in MS, showing both evidence of WML as well as volume loss, which are associated with clinical symptomatology [74–76]. Here we observed brainstem volume loss in a very early-stage of RRMS, which is corroborated by findings from Eshaghi et al (2018) [14].…”

Section: Discussionsupporting

confidence: 91%

Patterns of brain degeneration in early-stage relapsing-remitting multiple sclerosis

Meijboom

York

Kampaite

et al. 2021

Preprint

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Recurrent neuroinflammation in relapsing-remitting MS (RRMS) is thought to lead to neurodegeneration, resulting in progressive disability. Repeated magnetic resonance imaging (MRI) of the brain provides non-invasive measures of atrophy over time, a key marker of neurodegeneration. This study investigates regional neurodegeneration of the brain in early-stage RRMS using volumetry and voxel-based morphometry (VBM).RRMS patients (N=354) underwent 3T structural MRI at diagnosis and 1-year follow-up, as part of the Scottish multicentre ‘FutureMS’ study. MRI data were processed using FreeSurfer to derive volumetrics, and FSL for VBM (grey matter (GM) only), to establish patterns of change in GM and normal-appearing white matter (NAWM) over time throughout the cerebrum, cerebellum and brainstem.Volumetric analyses showed a decrease over time (q<0.05) in bilateral cortical GM and NAWM, multiple subcortical structures, cerebellar GM and the brainstem. Additionally, NAWM and GM volume decreased respectively in the following cortical regions, frontal: 14 out of 28 regions and 17/28; temporal: 18/18 and 15/18; parietal: 14/14 and 11/14; occipital: 7/8 and 8/8. Left GM and NAWM asymmetry was observed in the frontal lobe. GM VBM analysis showed three major clusters of decrease over time: 1) temporal lobe and subcortical areas, 2) cerebellum, 3) anterior cingulum and supplementary motor cortex; and four smaller clusters within the occipital lobe.Widespread neurodegeneration was observed in early-stage RRMS; particularly in the brainstem, cerebellar GM, and subcortical and occipital-temporal regions. Volumetric and VBM results emphasise different as well as overlapping patterns of longitudinal change, and provide potential response markers for existing therapies and trials of neuroprotective agents.

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“…Larger cohort studies with long(er) FU are necessary to further explore the role of early infratentorial and spinal cord lesions on disability progression, especially long-term disability progression. Also, connectivity and atrophy of cerebellum, brainstem, 29,30 and spinal cord 19,31 might have been interesting to examine in relation to disability progression, but unfortunately this was not possible using data from this cohort.…”

Section: Discussionmentioning

confidence: 99%

Infratentorial and spinal cord lesions: Cumulative predictors of long-term disability?

et al. 2019

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Objective: The objective of the study was to determine whether early infratentorial and/or spinal cord lesions are long-term cumulative predictors of disability progression in multiple sclerosis (MS). Methods: We selected 153 MS patients from the longitudinal Amsterdam MS cohort. Lesion analysis was performed at baseline and year 2. Disability progression after 6 and 11 years was measured using the Expanded Disability Status Scale (EDSS) and EDSS-plus (including 25-foot walk and 9-hole peg test). Patients with spinal cord or infratentorial lesions were compared for the risk of 6- and 11-year disability progression to patients without spinal cord or infratentorial lesions, respectively. Subsequently, patients with lesions on both locations were compared to patients with only spinal cord or only infratentorial lesions. Results: Baseline spinal cord lesions show a higher risk of 6-year EDSS progression (odds ratio (OR): 3.6, p = 0.007) and EDSS-plus progression (OR: 2.5, p = 0.028) and 11-year EDSS progression (OR: 2.8, p = 0.047). Patients with both infratentorial and spinal cord lesions did not have a higher risk of 6-year disability progression than patients with only infratentorial or only spinal cord lesions. Conclusion: The presence of early spinal cord lesions seems to be a dominant risk factor of disability progression. Simultaneous presence of early infratentorial and spinal cord lesions did not undisputedly predict disability progression.

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Cervical cord area is associated with infratentorial grey and white matter volume predominantly in relapsing–remitting multiple sclerosis: A study using semi-automated cord volumetry and voxel-based morphometry

Cited by 12 publications

References 39 publications

Cervical cord and ventricle affection in neuromyelitis optica

Cervical cord and ventricle affection in neuromyelitis optica

Patterns of brain degeneration in early-stage relapsing-remitting multiple sclerosis

Infratentorial and spinal cord lesions: Cumulative predictors of long-term disability?

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