Cervical Chordoma in Childhood Without Typical Vertebral Bony Destruction

Zhou, Hua; Liu, Zhongjun; Liu, Cuiling; Ma, Qilong; Liu, Xiaoguang; Jiang, Liang; Wei, Feng

doi:10.1097/brs.0b013e3181a8ced8

Cited by 13 publications

(8 citation statements)

References 25 publications

(34 reference statements)

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“…Surgical resection of cervical chordomas is challenging because of the specific anatomic constraints of the cervical spine, including vertebral arteries, nerve roots, and pedicles 34, 49, 50. Moreover, chordomas tend to inﬁltrate into neighboring soft tissues 9, 31, 51. Experience with en bloc excisions for cervical chordomas is limited 31, 33, 50, 52, 53, and we have to perform intralesional piecemeal excisions of tumors in the upper cervical spine, in spite of multiple anterior/posterior surgeries.…”

Section: Discussionmentioning

confidence: 99%

Differential proteomic profiling of chordomas and analysis of prognostic factors

Zhou

Chen

Lan

et al. 2010

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 99%

Differential proteomic profiling of chordomas and analysis of prognostic factors

Zhou

Chen

Lan

et al. 2010

Journal of Surgical Oncology

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“…The presence of an accompanying soft tissue mass, spanning several vertebral levels, is characteristic of chordomas ( 15 ). Soft tissue mass without bone involvement, as observed in 1 of the cases reviewed, has been previously described ( 15 – 18 ). MRI is useful in demonstrating the soft tissue mass.…”

Section: Discussionmentioning

confidence: 76%

“…Hemangiomas exhibit a polka dot appearance on axial images or a corduroy vertebra on sagittal images on CT scans. A number of cases without bone involvement have been described previously ( 15 – 18 ). In such cases, differentiation between chordoma and nerve sheath tumor may be difficult.…”

Section: Discussionmentioning

confidence: 99%

“…In such cases, differentiation between chordoma and nerve sheath tumor may be difficult. However, a number of stripes may be identified in chordoma on magnetic resonance T2-weighted images ( 18 ). Furthermore, the location of the paravertebral tumor mass lateral and anterior to the vertebral body was not indicative of a tumor of nerve root origin ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

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Computed tomography and magnetic resonance imaging features of cervical chordoma

et al. 2018

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Computed tomography (CT) and magnetic resonance imaging (MRI) scans of 11 patients with histologically proven cervical chordoma were retrospectively evaluated. Imaging features assessed included location, morphology, association with adjacent structures, vertebral destruction, status of cortical bone, periosteal reaction, attenuation and calcification by CT, and signal intensity and enhancement pattern by MRI. Of 7 cases with CT, 6 exhibited lytic-sclerotic bone destruction. A total of 5 cases exhibited pressure erosion of outer cortex, 3 of which had spiculated periosteal reaction. Calcification was observed in 3 cases. All cases were heterogeneous and hypodense. MRI T2-weighted images (n=10) revealed heterogeneous hyperintense (n=5), intermediate (n=2) and intermediate-hyperintense signal intensity (n=3). Hypointense septa between lobules (n=5) and stripes (n=3) were observed on T2-weighted images. Post-contrast magnetic resonance images (n=6) demonstrated marked heterogeneous (n=3) and ring-like (n=3) enhancement. CT scanning is valuable in revealing the lytic-sclerotic bone destruction, pressure erosion of outer cortex and calcification. MRI is useful in demonstrating the results of soft tissue mass. The two examinations are necessary for differential diagnosis of patients with suspected cervical chordoma.

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“…Chordomas rarely occur in people below 40 years old; however, numerous cases of pediatric chordomas have been reported (e.g., [4, 5]) and generally were associated with cranial locations [6]. While cranially located chordomas affect both genders equally, sacrococcygeal tumors are more frequent in males, with the male : female ratio being approximately 2 : 1 ([7], and references therein).…”

Section: Chordoma: Epidemiology Classification and Histopathologmentioning

confidence: 99%

From Notochord Formation to Hereditary Chordoma: The Many Roles ofBrachyury

Nibu

José-Edwards

Gregorio

2013

BioMed Research International

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Chordoma is a rare, but often malignant, bone cancer that preferentially affects the axial skeleton and the skull base. These tumors are both sporadic and hereditary and appear to occur more frequently after the fourth decade of life; however, modern technologies have increased the detection of pediatric chordomas. Chordomas originate from remnants of the notochord, the main embryonic axial structure that precedes the backbone, and share with notochord cells both histological features and the expression of characteristic genes. One such gene is Brachyury, which encodes for a sequence-specific transcription factor. Known for decades as a main regulator of notochord formation, Brachyury has recently gained interest as a biomarker and causative agent of chordoma, and therefore as a promising therapeutic target. Here, we review the main characteristics of chordoma, the molecular markers, and the clinical approaches currently available for the early detection and possible treatment of this cancer. In particular, we report on the current knowledge of the role of Brachyury and of its possible mechanisms of action in both notochord formation and chordoma etiogenesis.

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Cervical Chordoma in Childhood Without Typical Vertebral Bony Destruction

Abstract: Giant notochordal rest and benign notochordal cell tumors (BNCTs) need to be recognized for differential diagnosis of this atypical chordoma. A long-term follow-up might be necessary for the diagnosis of this nontypical patient.

Cited by 13 publications

References 25 publications

Differential proteomic profiling of chordomas and analysis of prognostic factors

Differential proteomic profiling of chordomas and analysis of prognostic factors

Computed tomography and magnetic resonance imaging features of cervical chordoma

From Notochord Formation to Hereditary Chordoma: The Many Roles ofBrachyury

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