Cervical Castleman's Disease in Childhood

Souza, Kelen Christine N.; Silva, Sindeval José; Salomão, Eliana Chaves; Silva, Arnaldo Moreira; Faria, Paulo Rogério de; Queiroz, Luciana Freitas; Cardoso, Sérgio Vitorino; Loyola, Adriano Mota

doi:10.1016/j.joms.2007.06.678

Cited by 12 publications

(11 citation statements)

References 19 publications

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“…More recently, Farruggia et al (2011) reviewing pediatric cases of Castleman disease, found a number of about 100 reported cases 12. The cases of CD in childhood are mostly of unicentric hyaline-vascular type10, like in the case reported here.…”

Section: Discussionsupporting

confidence: 60%

“…In the pediatric population, until 1999, 83 cases have been reported in the literature. Most of them were localized (86,7%), 27,7% in thoracic, 20% in abdominal lymph nodes, 15,6% in cervical and 6% in axillary topography 10 , 11. More recently, Farruggia et al (2011) reviewing pediatric cases of Castleman disease, found a number of about 100 reported cases 12.…”

Section: Discussionmentioning

confidence: 98%

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Castleman disease: an uncommon diagnosis in pediatrics

Vianna¹,

Pastore²,

Cristófani³

et al. 2012

ACR

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First described by Dr. Benjamin Castleman in 1956, Castleman disease is an uncommon disease of an etiology that is not yet thoroughly known. Three distinct histological subtypes have already been described: hyaline-vascular-, plasma cell-, and human herpes virus 8-associated variant, clinically distinguished in multi or unicentric types. Castleman disease is occasionally diagnosed in children, but more often in young adults, with no gender predominance. The symptoms are rather heterogeneous, varying from an asymptomatic mass in the unicentric Castleman disease type, to life-threatening systemic inflammatory state with systemic symptoms in the multicentric Castleman disease type. The authors report a case of a 15-year-old boy who sought medical attention due to a cervical tumor mass, without systemic symptoms. Pathology exam of the excised mass diagnosed a very typical example of the hyaline-vascular unicentric type of Castleman disease.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 98%

Castleman disease: an uncommon diagnosis in pediatrics

Vianna¹,

Pastore²,

Cristófani³

et al. 2012

ACR

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“…One nodal group or multiple nodal groups can be involved with greater than 90% of neck lesions being unifocal. [51][52][53][54][55] CECT typically demonstrates moderate to marked homogenous nodal contrast enhancement. Nodes are typically hypointense or isointense on T1WI and hyperintense on T2WI.…”

Section: Rare Lymphadenopathy Diseasesmentioning

confidence: 99%

Imaging of Head and Neck Lymph Nodes

Eisenmenger¹,

Wiggins²

2015

Radiologic Clinics of North America

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“…Given the largely nonspecific preoperative diagnostics, CD is a particularly difficult disease to diagnose without x x x Penfold 5 x x x Glazer 25 x None x Tuerlinckx 23 x None x Tuerlinckx 23 x Reference values not given Hodgkin's Lymphoma Patel 26 x x Enlarged, necrotic LN Bond 10 x x x Tan 27 x x x Zhong 17 x None x Chen 28 x x x Song 19 Inconclusive None x Song 19 Inconclusive None x Song 19 Inconclusive None x Chen 29 x x x Souza 11 Unspecific reactive lymphoid hyperplasia Positive-IgG rubella, CMV Lymphoma, reactive lymphadenitis Souza 11 Unspecific lymphoid hyperplasia from previous cytology Hypochromic microcytic anemia, thrombocytosis, high ESR, rheumatoid factor positive Cystic hygroma removed from same area 4 years prior Souza 11 Many small lymphocytes and lymph-histiocytic aggregates None Lymphoid hyperplasia, lymphangioma Rao 21 x None Reactive lymphadenopathy Cakabay 4 x None x Lin 14 x x x Zhong 6 x None x Zhong 6 x None x Lin 14 x x x Lin 14 x x x Chen 18 x x x Chen 18 x x x Chen 18 x x x Chen 18 x x x…”

Section: Implications For Practicementioning

confidence: 99%

“…Castleman disease can occur anywhere throughout the lymphatic system. The most common sites include the mediastinum (60%), neck (14%), abdomen (11%), and axilla (4%) 6‐11 . Although the underlying etiology is unknown, several hypotheses have been suggested.…”

mentioning

confidence: 99%

Castleman Disease in the Pediatric Neck: A Literature Review

Rabinowitz

Levi

Conard

et al. 2013

Otolaryngol.--head neck surg.

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In this article, we provide the largest known literature review of pediatric patients with cervical Castleman disease. Although Castleman disease is rare, it should be considered on the differential for a pediatric neck mass, particularly when presenting with an asymptomatic posterior neck mass and equivocal workup. Fortunately, our study suggests that if diagnosed as Castleman disease, the most likely diagnosis is hyaline-vascular type, for which the long-term prognosis is good. Surgical excision is both diagnostic and therapeutic.

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Cervical Castleman's Disease in Childhood

Cited by 12 publications

References 19 publications

Castleman disease: an uncommon diagnosis in pediatrics

Castleman disease: an uncommon diagnosis in pediatrics

Imaging of Head and Neck Lymph Nodes

Castleman Disease in the Pediatric Neck: A Literature Review

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