Cervical cancer screening programs and guidelines in low‐ and middle‐income countries

Olson, Brody; Gribble, Beth; Dias, Jasmyni; Curryer, Cassie; Vo, Kha; Kowal, Paul; Byles, Julie

doi:10.1016/j.ijgo.2016.03.011

Cited by 74 publications

(73 citation statements)

References 29 publications

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“…HPV vaccine has made a significant contribution to the primary prevention of cervical cancer, but there are still some new challenges ahead. Prevention of cervical cancer in some developing countries is still difficult to achieve in the short term [24,25]. Therefore, seeking a molecular biomarker of cervical cancer is still a hotspot issue.…”

Section: Discussionmentioning

confidence: 99%

CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8

Liu

Wang

Long

et al. 2018

Cell Physiol Biochem

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Background/Aims: Circular RNAs (circRNAs) play a significant role in the development and progression of various human cancers. However, the expression and function of circRNAs in cervical cancer (CC) have rarely been explored. The aim of this study was to investigate the biological function of circRNA8924 in CC and elucidate the possible molecular mechanism involved. Methods: Quantitative polymerase chain reaction was used to determine mRNA expression of circRNA8924, miR-518d-5p/519-5p and CBX8 in CC tissues and cells. CBX8 protein expression was measured by Western blotting. The CCK-8 assay was used to evaluate cell proliferation, and the transwell assay to determine cell migration and invasion. The luciferase reporter assay was used to determine the direct regulation of miR-518d-5p/519-5p and circRNA8924 or CBX8 Results: The study demonstrated that the expression level of circRNA8924 in CC was significantly higher than that in the adjacent normal tissues (P < 0.001), and that it was also associated with tumor size, FIGO staging and myometrial invasion. The knockdown of circRNA8924 significantly inhibited the proliferation, migration and invasion of CC cells SiHa and HeLa. The expression level of miR-518d-5p/519-5p was negatively correlated with circRNA8924, and circRNA8924 regulated CBX8 by competitively binding to miR-518d-5p/519-5p. Conclusions: CircRNA8924 is highly expressed in CC tissue and can be considered a competitive endogenous RNA of the miR-518d-5p/519-5p family to promote the malignant biological behavior of CC cells. It is suggested that it may serve as a new biomarker for CC diagnosis and disease progression and provide potential targets for targeted therapy.

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Section: Discussionmentioning

confidence: 99%

CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8

Liu

Wang

Long

et al. 2018

Cell Physiol Biochem

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“…Although cytology‐based CC screening programs have successfully reduced CC incidence in high‐income countries, such dramatic reduction in incidence has not been observed in low‐ and medium‐income countries (LMIC) . The incidence of invasive CC in sub‐Saharan Africa is expected to increase in the near future because of limited access of the population to information and health care facilities, an absence of sustained prevention programs, and high HIV prevalence .…”

Section: Introductionmentioning

confidence: 99%

Cervical cancer screening in a low‐resource setting: a pilot study on an HPV‐based screen‐and‐treat approach

et al. 2017

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Cervical cancer (CC) is the leading cause of cancer‐related death among women in sub‐Saharan Africa, primarily because of limited access to effective screening and preventive treatment. Our aim was to assess the feasibility of a human papillomavirus (HPV)‐based CC screen‐and‐treat approach in a low‐resource context. We recruited 1012 women aged 30–49 years through a CC screening campaign conducted in the District Hospital of Dschang, Cameroon. Participants performed HPV self‐sampling, which was tested for high‐risk HPV (HR‐HPV) DNA using the point‐of‐care Xpert HPV assay. All HPV‐positive women were invited for visual inspection with acetic acid and Lugol's iodine (VIA/VILI) to exclude CC or enable triage. A cervical sample for histological analysis was also collected. Women positive for HPV 16/18/45 and for other HR‐HPV with pathological VIA/VILI were selected to undergo treatment with thermocoagulation. The HPV prevalence in the study population was 18.5% (n = 187); of these cases, 20 (10.6%), 42 (22.3%) and 140 (74.9%) were positive for HPV16, HPV18/45 and other HR‐HPV types, respectively. Overall, 107/185 (57.8%) VIA/VILI examinations were classified as pathological and 78 (42.2%) as normal. Women positive for HPV16/18/45 were 4.2 times more likely to harbor cervical intraepithelial neoplasia grade 2 or worse (CIN2+) than those with other HPV types. The specificity of HPV 16/18/45 genotypes for detection of high‐grade lesions among HR‐HPV positive women was higher than that of VIA/VILI in all age groups. The sensitivity and specificity of VIA/VILI in detecting CIN2+ among HPV positive women were 80% and 44%, respectively. Overall, 110/121 screen‐positive women (90.9%) were eligible for, and were treated with, thermocoagulation. An HPV‐based screen‐and‐treat approach is feasible in a low‐resource context and may contribute to improving the effectiveness of CC prevention programs. Immediate thermocoagulation treatment for women who are HPV16‐ and/or HPV18/45‐positive is a practical approach for the treatment of CIN2+. The combination of HPV‐testing and VIA/VILI for CC screening might reduce overtreatment.

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“…Effective screening systems represent 1 best strategy for early detection and effective treatment of cervical cancer . Free cervical screening strategy in China was adapted in 2009, but participating rates remain relatively low . The lack of knowledge of cervical cancer risk and the unawareness of available screening service are considered as barriers .…”

Section: Introductionmentioning

confidence: 99%

“…7,8 Free cervical screening strategy in China was adapted in 2009, but participating rates remain relatively low. 9,10 The lack of knowledge of cervical cancer risk and the unawareness of available screening service are considered as barriers. 11 Findings from reported studies in other low-income and middle-income countries suggest women can be motivated to participate in screening by increase their knowledge of cervical cancer and awareness of screening services.…”

Section: Introductionmentioning

confidence: 99%

Protection motivation theory in predicting intention to receive cervical cancer screening in rural Chinese women

et al. 2017

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Cervical cancer screening programs and guidelines in low‐ and middle‐income countries

Abstract: Work must continue to improve the implementation of affordable, relevant, and achievable methods to improve screening coverage in LMICs.

Cited by 74 publications

References 29 publications

CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8

CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8

Cervical cancer screening in a low‐resource setting: a pilot study on an HPV‐based screen‐and‐treat approach

Protection motivation theory in predicting intention to receive cervical cancer screening in rural Chinese women

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