Cervical Cancer Induction Enhancement Potential of Chlamydia Trachomatis: A Systematic Review

Karim, Safae; Souho, Tiatou; Benlemlih, Mohammed; Bennani, Bahia

doi:10.1007/s00284-018-1439-7

Cited by 49 publications

(32 citation statements)

References 58 publications

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“…Mean values ± SD for each microbial parameter are shown. (Karim et al, 2018). Similarly, the protozoon Trichomonas vaginalis was not evidenced in any sample from our study group, contrary to previous reports (Ghosh et al, 2017).…”

Section: Discussioncontrasting

confidence: 99%

Vaginal Microbiota and Cytokine Microenvironment in HPV Clearance/Persistence in Women Surgically Treated for Cervical Intraepithelial Neoplasia: An Observational Prospective Study

Caselli

D’Accolti

Santi

et al. 2020

Front. Cell. Infect. Microbiol.

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High-risk human papillomaviruses (hrHPVs) are causally related to cervical intraepithelial neoplasia (CIN) and subsequent cervical cancer (CC). The vaginal microbiome has been suggested to play a role in the development of CC, but the effect of conservative surgical treatment on the microbiome and hrHPV elimination has not been elucidated. In this study, we aimed to characterize the vaginal microbiome and inflammatory chemokine profile in 85 women treated for CIN2-CIN3 lesions, before and after surgical CIN removal. The results showed, as expected, a high prevalence of dysbiotic microbiomes and vaginal proinflammatory cytokines in the CIN cohort, correlated with disease severity, at the basal level. By contrast, surgical CIN removal induced significant vaginal microbiome variations, and specific microbiome/cytokine profiles were associated with hrHPV clearance/ persistence at 6-month follow-up. hrHPV-cleared patients, in fact, showed a specific increase of L. crispatus and decrease of dysbiosis and inflammatory cytokines compared to hrHPV-persistent patients. These data highlight the crosstalk between HPV and the local microbiome, and suggest that vaginal microbiome modulation might represent a novel approach to modifying the natural history of hrHPV-related CC. Study registration n. ISRCTN34437150 (https://www.isrctn.com/ISRCTN34437150).

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Section: Discussioncontrasting

confidence: 99%

Vaginal Microbiota and Cytokine Microenvironment in HPV Clearance/Persistence in Women Surgically Treated for Cervical Intraepithelial Neoplasia: An Observational Prospective Study

Caselli

D’Accolti

Santi

et al. 2020

Front. Cell. Infect. Microbiol.

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“…The main reason for the death of patients with cervical cancer is cancer progression and metastasis. Hence, the current research investigated the underlying molecular mechanisms that participate in progression of cervical cancer [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-183-5p Inhibits Aggressiveness of Cervical Cancer Cells by Targeting Integrin Subunit Beta 1 (ITGB1)

Zhang

Liu

et al. 2018

Med Sci Monit

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BackgroundAccumulating studies demonstrate that microRNAs play crucial roles in multiple processes of cancer progression. Lower levels of miR-183 have ben observed in diverse types of tumors but the mechanism and precise function of miR-183-5p in cervical cancer have largely not been investigated.Material/MethodsThe level of miR-183-5p in different cervical cancer cell lines and clinical tissues was detected qRT-PCR assays. Transwell and wound-healing migration assays were conducted to assess the functional roles of miR-183-5p in over-expressing cervical cancer cells in vitro. Rescue assays were carried out to confirm the contribution of integrin subunit Beta 1 (ITGB1) to the aggressiveness of cancer cells regulated by miR-183-5p.ResultsmiR-183-5p was reduced in clinical tissues of cervical cancer and cell lines when compared to the normal subjects and normal cervical epithelial cell line, respectively. In addition, over-expression of miR-183-5p markedly inhibited migration and invasion in cervical cancer cells, and increased aggressiveness was observed in miR-183-5p inhibitor transfected cells. Furthermore, the luciferase reporter assays revealed that ITGB1 was the gene directly regulated by miR-183-5p. Notably, a negative association between the ITGB1 and miR-183-5p was found, and the gene expressions of ITGB1 was mediated by miR-183-5p in cervical cancer cells.ConclusionsmiR-183-5p serves as a latent anti-oncogene by targeting the metastasis-promoter gene, ITGB1.

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“…Роль ХЦ как ко-фактора при раке шейки матки доволь-но существенна. Исcледователи отметили положительную связь между воспалением шейки матки и плоскоклеточными интраэпителиальными поражениями [17,18].…”

Section: впч-инфекция цервицит и рак шейки маткиunclassified

Cervicitis: an Unresolved Gynecological Problem

Bebneva¹,

Оразов²,

Kostin³

2018

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Cervical Cancer Induction Enhancement Potential of Chlamydia Trachomatis: A Systematic Review

Cited by 49 publications

References 58 publications

Vaginal Microbiota and Cytokine Microenvironment in HPV Clearance/Persistence in Women Surgically Treated for Cervical Intraepithelial Neoplasia: An Observational Prospective Study

Vaginal Microbiota and Cytokine Microenvironment in HPV Clearance/Persistence in Women Surgically Treated for Cervical Intraepithelial Neoplasia: An Observational Prospective Study

MicroRNA-183-5p Inhibits Aggressiveness of Cervical Cancer Cells by Targeting Integrin Subunit Beta 1 (ITGB1)

Cervicitis: an Unresolved Gynecological Problem

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