Cervical cancer incidence and mortality rates in Kentucky

Silva, Scott R.; Gaskins, Jeremy; Nichols, Matthew; Metzinger, Daniel S.; Todd, Sarah; Eldredge-Hindy, Harriet

doi:10.1016/j.ygyno.2020.05.011

Cited by 5 publications

(8 citation statements)

References 34 publications

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“…Our study showed increasing trends of cervical cancer incidence in Guangzhou from 2004 to 2018, which were driven by cohort and period effects. Similar increasing trends were also observed in other regions of China [ 4 ], Russia [ 20 ], some countries of Central and Eastern Europe [ 21 ] and Africa [ 7 , 22 , 23 ]. As high-risk human papillomavirus (HPV) types are necessary cause of cervical cancer, the increasing cervical cancer incidence in Guangzhou could be due to the following reasons.…”

Section: Discussionsupporting

confidence: 80%

Disparities in the increases of cervical cancer incidence rates: observations from a city-wide population-based study

Wang

et al. 2022

BMC Cancer

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Background Globally cervical cancer incidence rate has been declining continuously. However, an unfavorable trend has been observed in China during the past decades, and the underlying reasons remain unclear. We hereby explore the recent trends of cervical cancer incidence, as well as the underlying determinants using data from Guangzhou, one of biggest cities in China. Methods City-wide cancer registration data were obtained from the Guangzhou Center for Disease Prevention and Control from 2004 to 2018. We used the Joinpoint regression models to estimate the average annual percentage change (AAPC) of age-standardized and age-specific incidence rates by regions and by histological subtype. Age-period-cohort models were applied to analyze the period and birth cohort effects on the time trends. Results The age-standardized rates (ASRs) of cervical cancer incidence increased at an annual rate of 2.1% [95% confidence interval (CI): 1.0%-3.2%] during 2004–2018. The largest increase in ASRs was found for rural regions, with AAPC of 6.6% [95% CI: 3.7%-9.5%], followed by the suburbs (2.2% [95% CI: 1.0%-3.4%]), while there was no statistically significant increase in urban regions. The ASRs of adenocarcinoma increased faster than those of the squamous cell carcinoma (AAPC = 6.53% [95% CI: 5.0%-8.1%] versus 1.79% [95% CI: 0.8%-2.8%]). A downward trend in urban regions was found in the 20–49 age group, whereas an upward trend was found in the 50 + age group, especially in rural regions. An inverted V-shape was found for cohort effects, with the peak varied by regions, i.e., peaked in the 1966 and 1971 birth cohort in the urban and suburb regions, respectively. Period effects kept increasing during the study period. Conclusions We systematically examine the disparities in the increases of cervical cancer incidence rates using city-wide data from Guangzhou. Extensive efforts are warranted to address the large urban–rural disparities in cervical cancer prevention. The combined strategies of vaccination, screening, and health education should be reinforced and locally customized.

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Section: Discussionsupporting

confidence: 80%

Disparities in the increases of cervical cancer incidence rates: observations from a city-wide population-based study

Wang

et al. 2022

BMC Cancer

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“…Our study showed increasing trends of cervical cancer incidence in Guangzhou from 2004 to 2018, which were driven by cohort and period effects. Similar increasing trends were also observed in other regions of China [4], Russia [19], some countries of Central and Eastern Europe [20] and Africa [7,21,22]. As high-risk human papillomavirus (HPV) types are necessary cause of cervical cancer, the increasing cervical cancer incidence in Guangzhou could be due to the following reasons.…”

Section: Discussionsupporting

confidence: 58%

Disparities in the Increases of Cervical Cancer Incidence Rates: Observations from a City-wide Population-based Study

Wang

et al. 2021

Preprint

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Background: Globally cervical cancer incidence rate has been declining continuously. However, an unfavorable trend has been observed in China during the past decades, and the underlying reasons remain unclear. We hereby explore the recent trends of cervical cancer incidence, as well as the underlying determinants using data from Guangzhou, one of biggest cities in China. Methods：City-wide cancer registration data were obtained from the Guangzhou Center for Disease Prevention and Control from 2004 to 2018. We used the Joinpoint regression models to estimate the average annual percentage change (AAPC) of age-standardized and age-specific incidence rates by regions and by histological subtype. Age-period-cohort models were applied to analyze the period and birth cohort effects on the time trends. Results: The age-standardized rates (ASRs) of cervical cancer incidence increased at an annual rate of 2.1% [95% confidence interval (CI): 1.0%-3.2%] during 2004-2018. The largest increase in ASRs was found for rural regions, with AAPC of 6.6% [95% CI: 3.7%-9.5%], followed by the suburbs (2.2% [95% CI: 1.0%-3.4%]), while there was no statistically significant increase in urban regions. The ASRs of adenocarcinoma increased faster than those of the squamous cell carcinoma (AAPC=6.53% [95% CI: 5.0%-8.1%] versus 1.79% [95% CI: 0.8%-2.8%]). A downward trend in urban regions was found in the 20-49 age group, whereas an upward trend was found in the 50+ age group, especially in rural regions. An inverted V-shape was found for cohort effects, with the peak varied by regions, i.e., peaked in the 1966 and 1971 birth cohort in the urban and suburb regions, respectively. Period effects kept increasing during the study period. Conclusions: We systematically examine the disparities in the increases of cervical cancer incidence rates using city-wide data from Guangzhou. Extensive efforts are warranted to address the large urban-rural disparities in cervical cancer prevention. The combined strategies of vaccination, screening, and health education should be reinforced and locally customized.

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“…The different geographic areas within Kentucky were previously described. 9 Briefly, urban and rural counties in this study are defined by the US Office of Management and Budget (OMB). The OMB states that for an area to be considered metropolitan, it must have an urban core population of at least 50,000, which includes any neighboring counties that have a high degree of interaction with the urban core.…”

Section: Methodsmentioning

confidence: 99%

Trends in Incidence and Mortality Rates of Uterine Cancer in Kentucky

Nichols¹,

Gaskins²,

Metzinger³

et al. 2021

Southern Medical Journal

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Objectives: The objective of this analysis was to gauge how the incidence and mortality of uterine cancer in Kentucky have changed from 1995 through 2017. An assessment of the trends in incidence and mortality across different geographic areas and between different races was also performed.Methods: Age-adjusted annual incidence and mortality rates for uterine cancer were obtained from the Kentucky Cancer Registry. A metaregression framework was used to assess changes in incidence and mortality rates during the time frame and to determine differences in these rates between rural versus urban counties, Appalachian versus non-Appalachian counties, and Black versus White women. Results:The incidence of uterine cancer has significantly increased throughout the state of Kentucky since 1995. Uterine cancer incidence was 10% and 22% higher in rural and Appalachian counties, respectively, compared with urban and non-Appalachian counties (P < 0.0001) from 1995 through 2017. In contrast, urban and non-Appalachian women had higher or equivalent age-adjusted mortality from uterine cancer, compared with rural and Appalachian women, respectively. The incidence of uterine cancer was significantly higher in White women compared with Black women from 1995 through 2006, but since 2007, there has been no significant difference in uterine cancer incidence based on race. Black women had higher age-adjusted mortality than White women throughout the entire time period examined. Conclusions:The incidence of uterine cancer is higher in rural and Appalachian Kentucky, without a corresponding geographic trend in mortality. Uterine cancer mortality is significantly higher in Black women.

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Cervical cancer incidence and mortality rates in Kentucky

Cited by 5 publications

References 34 publications

Disparities in the increases of cervical cancer incidence rates: observations from a city-wide population-based study

Disparities in the increases of cervical cancer incidence rates: observations from a city-wide population-based study

Disparities in the Increases of Cervical Cancer Incidence Rates: Observations from a City-wide Population-based Study

Trends in Incidence and Mortality Rates of Uterine Cancer in Kentucky

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