Cervical cancer in young Japanese women

Ito, Tetsuhide; Ishizuka, Takao; Suzuki, Kazuhiro; Ikoma, Y.; Saito, Junko; Onuma, Makiko; Miwa, Takaaki; Hashiba, Yukihiro; Kuno, Naohiko; Horibe, N.; Mizuno, Kimio; Ishikawa, Kaoru; Kazeto, S.

doi:10.1007/s004040000076

Cited by 14 publications

(12 citation statements)

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“…Many reports have suggested that the incidence of cervical cancer in young women is continuing to increase steadily [23][24][25]. The majority of invasive cancers are squamous cell carcinomas, although greater prevalence of adenocarcinoma and adenosquamous carcinoma in young women have been reported [25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma

et al. 2009

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Adenosquamous carcinoma of the uterine cervix is a rare mixture of malignant squamous and glandular epithelial elements and accounts for approximately 10% of cervical carcinomas. The aims of the present study were to evaluate the prevalence, physical status, and viral load of HPV 16 and 18 in adenosquamous carcinoma. Formalin-fixed paraffin-embedded tissue samples from 20 cases of histologically diagnosed adenosquamous carcinoma were examined. The squamous and glandular components were separately microdissected and analyzed for their HPV DNA subtype, viral load, and physical status using real-time polymerase chain reaction (PCR). The percentages of HPV 16- and 18-positive cases among all the HPV-positive cases were 36.8% (7/19) and 57.9% (11/19) in the squamous epithelial elements and 33.3% (6/18) and 61.1% (11/18) in the glandular elements, respectively. PCR analysis with E2 primers revealed that seven of eleven (63.6%) HPV 18-positive cases had the pure integrated form in both elements. The mean HPV 16 DNA copy numbers/cell was 7.22 in the squamous elements and 1.33 in the glandular elements (p=0.04) while the corresponding mean HPV 18 DNA copy numbers/cell was 1.50 and 0.89, respectively. The prevalence of HPV 18 in adenosquamous carcinoma was high and many HPV 18-positive cases were the pure integrated form resulting in very low copy numbers/cell. It is possible that more aggressive transformation with early integration of HPV 18 results in cases with greater chromosomal instabilities, higher growth rates, and rapid progression.

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Section: Discussionmentioning

confidence: 99%

Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma

et al. 2009

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“…There has been an increase in the incidence of cervical cancer among young women in the developed countries (Wright et al 1994;Hamasaki et al 1998;Morimura et al 1998;Anttila et al 1999;Ito et al 2000). Very recently, the Ministry of Health, Labor and Welfare proposed that cervical cancer screening should be conducted for women aged 20 to 29 years old even in Japan.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, there has been an increase in incidence of cervical cancer among young women in Japan. While the overall morbidity rate of cervical cancer has been declining, the morbidity rate in the 20's and 30's age groups has been rising (Wright et al 1994;Hamasaki and Yoshida 1998;Morimura et al 1998;Sato et al 1998;Ito et al 2000; Miyagi Cancer Society subjects who required close examination, 34 cases underwent treatment, and 17 cases were under age 30. Moreover, all three cases of microinvasive and/or invasive carcinoma were under the age of 30 years (23, 23, 27 years old, respectively).…”

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confidence: 99%

Cervical Cytologic Examination During Physical Checkup of Pregnant Women: Cervical Cancer Screening in Women Under the Age of Thirty

Abe

Itō

Okamura

et al. 2004

Tohoku J. Exp. Med.

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Recently, the Ministry of Health, Labor and Welfare proposed that cervical cancer screening should be conducted for women aged 20 to 29 years old in Japan. However, there are insufficient data available in Japan concerning the screening conducted for women under the age of 30. Therefore, we made a survey of the results of cervical cytologic examination for pregnant women. 28 616 pregnant women were examined as subjects of a study group. A group of 108 289 women, subjected to group screening for cervical cancer in Miyagi Prefecture, were studied as a control group. The rate of subjects who required close examination in the pregnant women's group was significantly higher than that in the mass screening group (1.12% vs. 0.84%). The rate of close examination was significantly higher in the women 19 years old or younger compared to those in the age group of 25 to 39 years old. The rate was also significantly higher in women aged 20 to 24 years old than those who are 25 to 34 years old. Of the 321

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“…Although a substantial decrease in both incidence and mortality rates has been observed in the past 30 years, with the age of patients becoming increasingly younger (2,3). More than 100,000 cervical cancer cases are diagnosed in China each year, and lymph node metastasis is the most common form of metastasis in the early stages of cervical cancer (4).…”

Section: Introductionmentioning

confidence: 99%

Correlation of macrophage migration inhibitory factor gene polymorphism with the risk of early-stage cervical cancer and lymphatic metastasis

Lian

Tao

et al. 2011

Oncology Letters

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Abstract. Associations of functional single nucleotide polymorphisms in MIF-173G/C with early stage cervical cancer were investigated in a hospital-based case-control study on 250 patients with cervical cancer prior to surgery (including 49 cases with and 201 cases without lymphatic metastasis) and 147 healthy controls. The polymorphism was assessed using restriction fragment length polymorphism polymerase chain reaction, and the MIF serum concentration was examined using the enzyme-linked immunosorbent assay to analyze the correlation between the polymorphism and the MIF serum concentration. Carriers of the variant C allele in MIF-173 were at a significantly higher risk of cervical cancer compared to carriers of the wild-type allele (aOR=1.508; 95% CI, 1.128-2.016, p=0.05). The GC and CC genotypes may be the causative factors for cervical cancer (aOR=1.851; 95% CI, 1.132-3.027, p=0.013). Individuals with the GC+CC genotype and C allele at the MIF-173G/C site were at a significantly higher risk of cervical cancer and lymphatic metastasis. The risk of lymphatic metastasis in early stage cervical cancer was increased more than 1.6 times in patients with the CC and GC genotypes compared with those with the GG genotype. The genotype distribution and allele frequency of MIF-173G/C were statistically significant in the well-, moderately and poorly differentiated groups (P<0.05). Compared to the GG genotype and G allele, patients with GC and CC genotypes and C allele exhibited a lower degree of differentiation and a higher degree of malignancy. A significant difference was observed in MIF serum concentrations among the various subgroups (P<0.05). The early cervical cancer, lymphatic metastasis and poorly differentiated groups exhibited higher MIF levels in serum. Moreover, patients with the CC genotype exhibited higher MIF serum concentration, which could increase the risk of early stage cervical cancer and lymphatic metastasis. The results presented in this study provide the first evidence that the genetic polymorphism MIF-173 is associated with cervical cancer in humans. Detection of MIF serum concentration and genotyping may be used as biomarkers for early diagnosis and therapy for cervical cancer.

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Cervical cancer in young Japanese women

Cited by 14 publications

References 0 publications

Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma

Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma

Cervical Cytologic Examination During Physical Checkup of Pregnant Women: Cervical Cancer Screening in Women Under the Age of Thirty

Correlation of macrophage migration inhibitory factor gene polymorphism with the risk of early-stage cervical cancer and lymphatic metastasis

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