Cervical cancer in pregnancy: diagnosis, staging and treatment

Howe, Tamara; Lankester, Kate; Kelly, Tony; Watkins, Ryan; Kaushik, Sonali

doi:10.1111/tog.12783

Cited by 5 publications

(10 citation statements)

References 35 publications

(53 reference statements)

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“… 3 Symptoms of cervical cancer in pregnancy are the same as in the non-pregnant population. 5 In the present case, our patient only complained of 1-month-long contact bleeding with no other additional symptoms. Early-stage cervical cancer may present as asymptomatic and can only be detected through cervical cytology.…”

Section: Discussionmentioning

confidence: 45%

“…The interval between termination and last chemotherapy cycle will allow both maternal and fetal bone marrow to recuperate. 5 , 7 …”

Section: Case Reportmentioning

confidence: 99%

“… 4 However, cervical cancer in pregnancy is still considered a rare occurrence, with an estimated incidence of 0.1–12.0 per 10.000 pregnancies. 5 Most patients are diagnosed in early stage due to the wide availability of prenatal screening. Furthermore, advanced diseases might hinder conception.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, antenatal care is often neglected by pregnant women, especially in developing countries, thus hindering tumor detection and leading to advanced stage upon presentation. 5 , 6 …”

Section: Introductionmentioning

confidence: 99%

“…Management of cervical cancer in pregnancy should involve a multidisciplinary team and should be individualized based on each patient’s gestational age and staging. 5 …”

Section: Introductionmentioning

confidence: 99%

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Clinical and Management Dilemmas Concerning Early-Stage Cervical Cancer in Pregnancy – A Case Report

Kurniadi¹,

Setiawan²,

Kireina³

et al. 2023

IJWH

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Background Cervical cancer in pregnancy is rare and its management remains a formidable challenge. Clinical upstaging is a serious concern. Presentation may mimic pregnancy-related conditions, thus delaying diagnosis and leading to an advanced stage at presentation. In addition, concerns regarding chemotherapy safety in pregnancy may hinder its administration. Definitive therapy may also be delayed due to pregnancy. Case Report A 37-year-old G3P2A0 10–11 weeks pregnant woman was diagnosed with stage IB2 cervical cancer. We originally planned to perform neoadjuvant chemotherapy with paclitaxel 175mg/m 2 and carboplatin 6 AUC every 21 days followed by caesarean section and radical hysterectomy. However, preoperatively, the tumor had grown further and progressed to stage IIB. Postpartum radiotherapy was thus indicated. Lower segmental caesarean section along with bilateral salpingectomy and ovarian transposition were performed. Radiotherapy was administered through external beam radiation therapy and brachytherapy. The patient delivered a small for gestational age male baby with no abnormalities. At 2-month follow-up, the infant appeared generally healthy. Conclusion Cancer diagnosis during pregnancy adversely impacts women’s physical and psychological states. Symptoms may mimic pregnancy-related conditions, thus delaying diagnosis. Its management involves a multidisciplinary team to protect both maternal and fetal health.

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Section: Discussionmentioning

confidence: 45%

“…The interval between termination and last chemotherapy cycle will allow both maternal and fetal bone marrow to recuperate. 5 , 7 …”

Section: Case Reportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Management of cervical cancer in pregnancy should involve a multidisciplinary team and should be individualized based on each patient’s gestational age and staging. 5 …”

Section: Introductionmentioning

confidence: 99%

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