Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Clinical trials in low and middle-income countries — Successes and challenges

“…In the 2016 ASCO Resource-Stratified Clinical Practice Guideline, recommendations were made on alternative best treatment options for clinicians practicing in these settings (Chuang et al, 2016). The Guideline was developed based on review of existing guidelines or expert consensus opinions when evidence was not available (Colombo et al, 2012, Ebina et al, 2015, Hirte et al, 2015, Koh et al, 2015). A four-tier approach (basic, limited, enhanced, and maximal) was developed based on recommendations by the Breast Health Global Initiative (Anderson & Distelhorst, 2008).…”

Clinical and Histopathological Comparison of Two Historical Series of 142 Wertheim-Meigs Operations Performed in a Reference Center in Brazil

“…Without treatment, the transition from dysplasia to invasive carcinoma may take years to decades to develop in most women. In addition, adenocarcinoma in situ appears to be more difficult to detect on Papanicolaou testing and this is thought to be one of the reasons for the increasing incidence of subtype of cervical cancer (HPV 18) [8,11]. The screening is realized through cytology each 3 years and with HPV and cytology co-testing every 5 years, preferred [7].…”

“…This examination has better effectiveness in identifying intraepithelial neoplasias and precursors of SCC in relation to precursors of adenocarcinomas. Positive pelvic lymph node is one of the most important prognostic factors in cervical cancer [4,[7][8][9]13,18,19]. Increased rates of lymph node metastasis in the comparison of the two historical series maintained a close relationship with the concomitant growth of adenocarcinoma type.…”

“…According to the NCCN, this surgery could also be indicated in stages IB2, although the most usual approach is to use radiotherapy with concurrent chemotherapy in such cases [4,7]. Alternatively, ESMO suggest neoadjuvant chemotherapy followed by radical hysterectomy in selected cases, although it is not a standard practice [8].…”

Follow-Up for Cervical Cancer: A Program in Evidence-Based Care Systematic Review and Clinical Practice Guideline Update

“…Most cervical cancers are squamous cell carcinomas (sccs); adenocarcinoma accounts for 10%-15% of cases 2 . Depending on disease stage, treatment consists of surgery, radiation therapy, or a combination of radiation and chemotherapy 2 , and the risk of recurrence ranges from 13% to 17% 3 .…”