Cervical Cancer Burden and Prevention Strategies: Asia Oceania Perspective

Garland, Suzanne M.; Bhatla, Neerja; Ngan, Hextan Y.S.

doi:10.1158/1055-9965.epi-12-0164

Cited by 26 publications

(18 citation statements)

References 31 publications

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“…g Downregulation of HOTAIR induced notably G1 phase arrest in HeLa cells, which was neutralized by the inhibition of p21. h Elevation of HOTAIR promoted the C33A cells into S phase, while abundant p21 reversed this phenomenon (the proliferative marker) was downregulated while p21 was upregulated by the knockdown of HOTAIR, and this effect was enhanced in the group of combination of HOTAIR knockdown and radiation heavy economic burden [27][28][29][30]. During the disease progression, tumor invasion and distant metastasis occur in a majority of patients, which accounts for most deaths related with cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

HOTAIR enhanced aggressive biological behaviors and induced radio-resistance via inhibiting p21 in cervical cancer

et al. 2014

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We previously reported the frequent overexpression of HOX Antisense Intergenic RNA (HOTAIR) in human cervical cancer, which was significantly correlated with tumor progression and poor prognosis. In the present study, we investigated the detailed biological functions of HOTAIR in cervical cancer. In vitro, upregulation of HOTAIR inhibited apoptosis and promoted cellular proliferation, cell cycle progression, migration, and invasion; on the contrast, downregulation of HOTAIR induced more apoptosis, suppressed cellular proliferation, cell cycle, migration, and invasion. Moreover, a high level of HOTAIR was notably associated with radio-resistance and downregulation of p21 in the primary cultured cervical cancer cells. Further, we demonstrated that elevated HOTAIR could induce radio-resistance via inhibiting p21 in HeLa cells, while knockdown of HOTAIR upregulated p21 and consequentially increased the radio-sensitivity of C33A cells. Consistently, stable knockdown of HOTAIR significantly suppressed tumor growth and sensitized cervical cancer to radiotherapy in vivo. In conclusion, HOTAIR served as an onco-lncRNA in cervical cancer which could enhance various aggressive biological behaviors. Moreover, we proved that HOTAIR execute its functions mainly through inhibiting the p21 expression. These results proposed that targeting HOTAIR might be a potent therapeutic strategy in cervical cancer, especially for those patients who accepted radiotherapy.

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Section: Discussionmentioning

confidence: 99%

HOTAIR enhanced aggressive biological behaviors and induced radio-resistance via inhibiting p21 in cervical cancer

et al. 2014

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“…The barriers listed where deducted from previous recommendations from successful cervical cancer prevention programs (Garland et al, 2008a; Garland et al, 2008b; Garland et al, 2012). Barriers were subsequently grouped as highly important (score of ten to eight), of medium importance (score of seven to four) or of low importance (score of three to one) and for each barrier the proportions of countries that reported each barrier of high, medium or low importance were calculated.…”

Section: Methodsmentioning

confidence: 99%

“…This translates into approximately 800 new cases of cervical cancer and 500 preventable deaths per year (Parkin et al, 2008; Foliaki et al, 2011; IARC, 2012; Obel et al, 2014). The Melanesian island countries rank among the highest cervical cancer incidence and mortality rates in the world (Ferlay et al, 2010; Garland et al, 2012; IARC, 2012) and recent cancer registration from the Micronesian islands found similarly high cervical cancer incidence with the great majority of cases diagnosed at advanced stages (stage II or higher) which is beyond the on-island treatment capacity (Buenconsejo-Lum et al, 2014). Despite the high burden of disease, only a few studies of HPV and cervical cancer have been conducted in the Pacific Region, and there is no updated regional information published regarding screening and vaccination practices in the Pacific Region.…”

Section: Introductionmentioning

confidence: 99%

Mapping HPV Vaccination and Cervical Cancer Screening Practice in the Pacific Region-Strengthening National and Regional Cervical Cancer Prevention

Obel

McKenzie²,

Buenconsejo-Lum³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Objective To provide background information for strengthening cervical cancer prevention in the Pacific by mapping current human papillomavirus (HPV) vaccination and cervical cancer screening practices, as well as intent and barriers to the introduction and maintenance of national HPV vaccination programmes in the region. Materials and Methods A cross-sectional questionnaire-based survey among ministry of health officials from 21 Pacific Island countries and territories (n=21). Results Cervical cancer prevention was rated as highly important, but implementation of prevention programs were insufficient, with only two of 21 countries and territories having achieved coverage of cervical cancer screening above 40%. Ten of 21 countries and territories had included HPV vaccination in their immunization schedule, but only two countries reported coverage of HPV vaccination above 60% among the targeted population. Key barriers to the introduction and continuation of HPV vaccination were reported to be: (i) Lack of sustainable financing for HPV vaccine programs; (ii) Lack of visible government endorsement; (iii) Critical public perception of the value and safety of the HPV vaccine; and (iv) Lack of clear guidelines and policies for HPV vaccination. Conclusion Current practices to prevent cervical cancer in the Pacific Region do not match the high burden of disease from cervical cancer. A regional approach, including reducing vaccine prices by bulk purchase of vaccine, technical support for implementation of prevention programs, operational research and advocacy could strengthen political momentum for cervical cancer prevention and avoid risking the lives of many women in the Pacific.

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“…1 It is also one of the biggest health threats to women in developing countries, especially in Asia, with more than 50% of cervical cancer cases worldwide. 2 It is reported that tumor metastasis has led to as much as 90% of cancer-related deaths. 3 For cervical cancer, invasion and migration play critical roles in the progression of cancer metastasis.…”

mentioning

confidence: 99%

RhoC Mediates Invasion and Migration of CaSki Cells Through the Rho-Associated Serine-Threonine Protein Kinase 1 Signaling Pathway

Chen¹,

Cheng²,

Zhang

et al. 2014

Int J Gynecol Cancer

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Cervical Cancer Burden and Prevention Strategies: Asia Oceania Perspective

Cited by 26 publications

References 31 publications

HOTAIR enhanced aggressive biological behaviors and induced radio-resistance via inhibiting p21 in cervical cancer

HOTAIR enhanced aggressive biological behaviors and induced radio-resistance via inhibiting p21 in cervical cancer

Mapping HPV Vaccination and Cervical Cancer Screening Practice in the Pacific Region-Strengthening National and Regional Cervical Cancer Prevention

RhoC Mediates Invasion and Migration of CaSki Cells Through the Rho-Associated Serine-Threonine Protein Kinase 1 Signaling Pathway

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