Cervical Cancer and Genital Infections: Assessment of Performance and Validation in Human Papillomavirus Genotyping Assays in Iran, its Neighbouring Countries and Persian Gulf Area

Sohrabi, Amir; Hajia, Massoud

doi:10.30699/ijp.2017.24229

Cited by 15 publications

(15 citation statements)

References 55 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was reported that HPV prevalence in worldwide women had significantly regional variation, for example in 2012 Africa had the highest HPV prevalence (24%), which followed by Eastern Europe (21%), Latin American (16%) and South Eastern Asia (14%) in turn [11]. In the current study, the overall HPV prevalence (10.16%) in Hengyang district of Hunan Province was comparable to those reported in Zhejiang Province (13.3%) [12] in China, and those reported in other countries, such as in Guatemala (13%) [13] and in Iran, its Neighbouring Countries and Persian Gulf Area (0.62%~25%) [14], but was lower than those reported in some regions of China, such as Shenzhen City (15.9%) [15], the northwestern Yunnan Province (18.4%) [16], southern Yunnan Province (14.7%) [17],…”

Section: Discussionsupporting

confidence: 65%

HPV prevalence and genotype distribution among women from Hengyang district of Hunan province, China

Tang

Ding

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Human papillomavirus (HPV) infection can cause a variety of epithelial lesions, including even various malignant cancers, such as cervical cancer, vulvar cancer and etc. Most cervical cancers were closely associated with HPV infections. Therefore, understanding the ecological diversity of HPV prevalence and genotype distribution among various populations in different geographical regions was essential for optimizing HPV vaccination and maximizing vaccination effects. Aim This study was designed to investigate HPV infection prevalence and genotype distribution among women from Hengyang district of Hunan province in China.Methods A total of 12053 patient data from the three-level hospitals in Hengyang city between July 2016 and July 2017 were retrospectively analyzed. The HPV positive was identified by Polymerase chain reaction (PCR). The HPV PCR-Flow fluorescence assay was used for HPV genotyping. The Chi-square test was performed to compare the differences among HPV infection rates or HR-HPV ratio-in-positives.Results In this study, the HPV prevalence was 10.16% overall, and the multiple-type infection rate was 1.83%. The HR-HPV infection rate was 8.52%. The top six HPV genotypes were as follows in a descending order: HPV16, HPV58, HPV52, HPV39, HPV51, and HPV53. The patients who were above 60 years and below 21 years old were the most and second HPV prevalent group, respectively, the corresponding HR-HPV infection rates were the most and the third, respectively. The infection rates of HPV and HR-HPV among outpatients were lower than those among hospitalized-patients, respectively. Among the hospitalized-patients, the infection rates of HPV and HR-HPV among 50~60 years group were both the most, following by those among above 60 years group. The HR-HPV ratio-in-positive among HPV-positive patients with histopathologic examination was higher than that among those patients without. Among 52 HPV-positive patients with cervical squamous carcinoma, the ratio-in-positive of HPV16 was 61.54%.Conclusions This study demonstrated that the HPV prevalence varied with the age among women from Hengyang district of Hunan province in China and showed their HPV genotype distribution that HPV16, HPV58, HPV52, HPV39, HPV51 and HPV53 infection were more popular in this region, which could provide the experimental basis for Chinese public health measures on cervical cancer prevention.

show abstract

Section: Discussionsupporting

confidence: 65%

HPV prevalence and genotype distribution among women from Hengyang district of Hunan province, China

Tang

Ding

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Recently, it has been reported that mHPV infections are apparently more widespread than expected [13, 14]. Although the genital infections with mHPVs are common in either men or women [1, 15–17], the relative rates might not be representative for the prevalence due to the limited number of patients studied [13, 14, 18]. Nevertheless, since when the HPV-types have been performed by polymerase chain reaction (PCR) assays, mHPV infections have been more consistently described [19].…”

Section: Introductionmentioning

confidence: 99%

Epidemiological evaluation of human papillomavirus genotypes and their associations in multiple infections

et al. 2019

View full text Add to dashboard Cite

The aim of this study was to determine the frequency of multiple type human papillomavirus (HPV) infections, and whether any types are involved in multiple HPV-type infections (mHPV) more or less frequently than expected. From January 2012 to February 2018, 2848 cervico-vaginal swabs were analysed in the UOC Microbiology and Virology of Policlinico of Bari, Italy. HPV DNA detection was performed using initially nested-polymerase chain reaction (PCR) and subsequently multiplex real-time PCR assay. 1357/2848 samples (47.65%) were HPV DNA positive and 694/1357 (51.14%) showed mHPVs. The median number of mHPVs was 2 (interquartile range: 2–3). HPV-types more frequently detected were 42 (9.97%), 16 (8.92%), 53 (7.23%) and 31 (7.16%). Each detected HPV-type was involved in mHPVs in more than 50% of cases. Statistical analysis showed significant associations for all HPV-types except for 33, 43, 51, 58 and 82 HPV-types. The major number of significant pairwise associations were detected for the types 42 and 70. Only positive associations were detected. Further data are necessary to evaluate the clinical impact of the single combinations.

show abstract

“…As a result, some genital infections such as high-risk HPVs and STIs are the common causative pathogens of cervical cancer and genital disorders. In addition, multiple co-pathogens appear more likely to be linked and potential risk factors in development of cervical abnormalities, especially in patients with genital infections [14,[20][21][22][23][24]. The function of SNPs in the pathogenesis of cervical cancer coexisting with HPV genotypes and other microorganisms such as C. trachomatis, M. genitalium and HSV2 in genital disorders has not been extensively studied in developing countries.…”

Section: Discussionmentioning

confidence: 99%

The Impact of MTHFR 1298 A > C and 677 C > T Gene Polymorphisms as Susceptibility Risk Factors in Cervical Intraepithelial Neoplasia Related to HPV and Sexually Transmitted Infections

Sohrabi

Bassam-Tolami

Imani

2020

J Obstet Gynecol India

Self Cite

View full text Add to dashboard Cite

Background HPV genotypes are the most common etiological factor for genital neoplasia. It would appear that sexually transmitted infections accompanied with HPV genotypes might have synergistic interactions in cancer progression. The genetic polymorphisms are involved in metabolizing carcinogens which may contribute to the susceptibility of developing genital cancers by less efficient or overly down metabolic pathways and cell signaling. MTHFR polymorphisms are related to several metabolic disorders and human cancers. We investigated the contribution of MTHFR 1298 and MTHFR 677 polymorphisms as potential risk factors for outcomes with HPV genotypes and STIs in Iranian population. Materials and Methods As a case-control study, MTHFR A1298C and C677T were assessed for SNPs analysis using a PCR-RFLP assay in 50 cervical intraepithelial neoplasia (CIN) cases, 98 HPV-positive subjects and 47 non-cancerous/ non-HPV patients as healthy controls. Results Finding suggested a significant association between the MTHFR 1298 CC polymorphisms (OR = 3.5, 95% CI = 1.13-10.82, P ≤ 0.05) in women with CIN as compared to non-cancerous/non-HPV subjects. There was not a significant difference of MTHFR 677 between outcomes. Discussion It would seem MTHFR 1298 CC is more likely to be a potential risk factor for HPV-cervical cancer progression. Consequences support further attempts to understand the clinical manifestations of neoplasia related to genital infections and gene mutations.

show abstract

Cervical Cancer and Genital Infections: Assessment of Performance and Validation in Human Papillomavirus Genotyping Assays in Iran, its Neighbouring Countries and Persian Gulf Area

Cited by 15 publications

References 55 publications

HPV prevalence and genotype distribution among women from Hengyang district of Hunan province, China

HPV prevalence and genotype distribution among women from Hengyang district of Hunan province, China

Epidemiological evaluation of human papillomavirus genotypes and their associations in multiple infections

The Impact of MTHFR 1298 A > C and 677 C > T Gene Polymorphisms as Susceptibility Risk Factors in Cervical Intraepithelial Neoplasia Related to HPV and Sexually Transmitted Infections

Contact Info

Product

Resources

About