Cervical cancer

Cohen, Paul A.; Jhingran, A.; Oaknin, Ana; Denny, Lynette

doi:10.1016/s0140-6736(18)32470-x

Cited by 1,736 publications

(1,532 citation statements)

References 103 publications

Supporting

Mentioning

1,327

Contrasting

Unclassified

Order By: Relevance

“…Human papillomavirus infection is an essential causal factor of cervical cancer, but the role of other etiological factors is unclear [24]. Cervix is often exposed to bacteria, and Gram-negative bacteriarelated inflammation has been reported [20].…”

Section: Discussionmentioning

confidence: 99%

HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancer

Liu

Fei

et al. 2020

Infect Agents Cancer

View full text Add to dashboard Cite

Cervical cancer is the fourth most common malignant tumor in women worldwide. The persistent infection of high-risk Human Papillomavirus (hrHPV) is considered to be the primary cause of this disease. As an innate immune receptor, the nucleotide-binding oligomerization domain protein-1 (NOD1) recognizes the pathogen-associated molecular pattern (PAMP), subsequently initiating immune responses. NOD1 is also involved in the apoptotic signaling pathway and mutates in many cancer cells. In the study, we revealed that NOD1 expression decreased during the progression of cervical intraepithelial neoplasia to cervical cancer and that HPV16 E6/E7 oncoproteins induced down-regulation of NOD1. Moreover, the activation of NOD1 promoted the apoptosis of HPV16-positive cervical cancer cells. The data indicated that the dysregulation of NOD1-mediated inflammation and apoptosis may contribute to cervical intraepithelial neoplasia progression and cervical cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancer

Liu

Fei

et al. 2020

Infect Agents Cancer

View full text Add to dashboard Cite

show abstract

“…[46] Cervical carcinoma (CC) is the cause of death of 300,000 women globally every year and patients with metastases and suffering from relapse have a poor prognosis. [47] Garcinol showed activity against CC models. Tumorigenesis of CC was correlated with Tcadherin expression and garcinol induced T-cadherin in vitro and in vivo via activation of PI3 K/AKT signaling in CC.…”

Section: Miscellaneous Cancersmentioning

confidence: 98%

“…Cervical carcinoma (CC) is the cause of death of 300,000 women globally every year and patients with metastases and suffering from relapse have a poor prognosis . Garcinol showed activity against CC models.…”

Section: An Update On the Activities Of Garcinol And Isogarcinol Agaimentioning

confidence: 99%

Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments

Schobert

Biersack

2019

Chemistry & Biodiversity

View full text Add to dashboard Cite

The natural polyisoprenylated benzophenone derivatives garcinol and isogarcinol are secondary plant metabolites isolated from various Garcinia species including Garcinia indica. This review takes stock of the recent chemical and biological research into these interesting natural compounds over the last five years. New biological sources and chemical syntheses are discussed followed by new insights into the activity of garcinol and isogarcinol against cancer, pathogenic bacteria, parasite infections and various inflammatory diseases.

show abstract

“…Cervical cancer is the fourth most common female malignancy worldwide [1]. Each year, more than half a million women are diagnosed with cervical cancer, and the disease results in over 300,000 deaths [2]. Cervical squamous cell carcinoma (SCC), as the most common histologic subtype, accounts for approximately 70% of all cases [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Each year, more than half a million women are diagnosed with cervical cancer, and the disease results in over 300,000 deaths [2]. Cervical squamous cell carcinoma (SCC), as the most common histologic subtype, accounts for approximately 70% of all cases [2,3]. Squamous cell carcinoma antigen (SCC-Ag) is well known as the most useful marker for cervical squamous cell carcinoma [4,5].…”

Section: Introductionmentioning

confidence: 99%

The kinetic profile and clinical implication of SCC-Ag in squamous cervical cancer patients undergoing radical hysterectomy using the Simoa assay: a prospective observational study

Sun

Kang

et al. 2020

BMC Cancer

View full text Add to dashboard Cite

Background: To study the kinetic profile and clinicopathological implications of squamous cell carcinoma antigen (SCC-Ag) in cervical cancer patients who underwent surgery by a self-developed SCC-Ag single molecule assay (Simoa) prototype immunoassay. Methods: Participants were prospectively enrolled between 04/2016 and 06/2017. Consecutive serum samples were collected at five points: day 0 (the day before surgery), postoperative day 4, weeks 2-4, months 2-4 and months 5-7. In total, 92 patients and 352 samples were included. The kinetic change in SCC-Ag levels and their associations with clinicopathological characteristics were studied. Results: Simoa SCC-Ag was validated by comparison with the Architect assay. SCC-Ag levels measured by the Simoa assay were highly correlated with the Architect assay's levels (Pearson's correlation coefficient = 0.979, Passing-Bablok regression slope 0.894 (0.847 to 0.949), intercept − 0.009 (− 0.047 to 0.027)). The median values for each time-point detected by the Simoa assay were 2.49, 0.66, 0.61, 0.72, and 0.71 ng/mL, respectively. The SCC-Ag levels decreased dramatically after surgery and then stabilized and fluctuated to some extent within 6 months. Patients with certain risk factors had significantly higher SCC-Ag values than their negative counterparts before surgery and at earlier time points after surgery, while no difference existed at the end of observation. Furthermore, although patients with positive lymph nodes had sustained higher SCC-Ag levels compared to those with negative lymph nodes, similar kinetic patterns of SCC-Ag levels were observed after surgery. Patients who received postoperative treatment had significantly higher SCC-Ag values than those with surgery only at diagnosis, while no difference existed after treatment. Conclusions: The Simoa SCC-Ag prototype was established for clinical settings. The SCC-Ag levels were higher in patients with risk factors, whereas the kinetic trend of SCC-Ag might be mainly affected by postoperative adjuvant therapy. These data indicate that the SCC-Ag level might be a good predictor for the status of cervical cancer, including disease aggressiveness and treatment response.

show abstract

Cervical cancer

Cited by 1,736 publications

References 103 publications

HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancer

HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancer

Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments

The kinetic profile and clinical implication of SCC-Ag in squamous cervical cancer patients undergoing radical hysterectomy using the Simoa assay: a prospective observational study

Contact Info

Product

Resources

About