Cervical adenoid basal tumors comprised of adenoid basal epithelioma associated with various types of invasive carcinoma: Clinicopathologic features, human papillomavirus DNA detection, and P16 expression

Parwani, Anil V.; Sehdev, Ann E. Smith; Kurman, Robert J.; Ronnett, Brigitte M.

doi:10.1016/j.humpath.2004.08.015

Cited by 55 publications

(54 citation statements)

References 19 publications

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“…Instead, these features have been taken as evidence to support an HPV-related form of ACC in other sites such as the cervix. (6–9) In the sinonasal tract, the dual presence of surface dysplasia and an invasive salivary-like carcinoma suggests that HPV infection with HPV-induced tumorigenesis may target the ductal system of intranasal minor salivary glands at or near its transition with the surface epithelium.…”

Section: Discussionmentioning

confidence: 99%

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Human Papillomavirus–related Carcinoma With Adenoid Cystic–like Features

Bishop¹,

Ogawa²,

Stelow

et al. 2013

American Journal of Surgical Pathology

145

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HPV-related carcinomas of the head and neck are characterized by a predilection for the oropharynx, a non-keratinizing squamous morphology, and infection with the HPV 16 type; but comprehensive HPV testing across all head and neck sites has shown that the pathologic features of HPV-related carcinoma may be more wide-ranging than initially anticipated. In particular, a subset of sinonasal carcinomas are HPV positive, and these include a variant that is histologically similar to adenoid cystic carcinoma (ACC). Cases were identified by retrospective and prospective analyses of head and neck carcinomas with ACC features. HPV analysis was performed using p16 immunohistochemistry and high risk HPV in-situ hybridization. HPV-positive cases were confirmed and typed using HPV type-specific quantitative PCR, and further characterized regarding their immunohistochemical profile and MYB gene status. HPV was detected in 8 carcinomas of the sinonasal tract, but it was not detected in any ACCs arising outside of the sinonasal tract. The HPV types were 33 (n=6), 35 (n=1) and indeterminate (n=1). Six patients were women and two were men, ranging in age from 40–73 years (mean 55). The carcinomas were characterized by a nested growth, a prominent basaloid component showing myoepithelial differentiation and forming microcystic spaces, and a minor epithelial component with ductal structures. Squamous differentiation, when present, was restricted to the surface epithelium. The carcinomas were not associated with the MYB gene rearrangement that characterizes a subset of ACCs. These cases draw attention to an unusual variant of HPV-related carcinoma that has a predilection for the sinonasal tract. Despite significant morphologic overlap with ACC, it is distinct in several respects including an association with surface squamous dysplasia, absence of the MYB gene rearrangement, and an association with HPV, particularly type 33. As HPV positivity confers distinct clinico-pathologic characteristics when encountered in the oropharynx, a more comprehensive analysis of risk factors, response to therapy and clinical outcomes is warranted for HPV-related carcinomas of the sinonasal tract.

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Section: Discussionmentioning

confidence: 99%

“…High risk HPV is frequently detected in the rare ACC arising in the cervix. (6–9) As for the head and neck, Boland et al detected high risk HPV in 7% of ACCs. (10) Notably, the HPV-positive cases were restricted to the sinonasal tract and exhibited a high grade solid component.…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus–related Carcinoma With Adenoid Cystic–like Features

Bishop¹,

Ogawa²,

Stelow

et al. 2013

American Journal of Surgical Pathology

145

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“…The co-existing ABC with occasionally identified transitional areas to other malignancy mainly ACC, also showing the potential precursor concept [5,9]. Additionally, an associated malignancy could occur by the co-incidence of transformed tumor by the common pathogenetic high-risk human papillomavirus (HPV) integration in both components [10-12]. Although the precise frequency of these rare co-existences is hampered by the selection bias on the case-report evidences, it has shown a substantial account [18] and thus stresses the significance of careful approach with a suspect of associating malignancy in any provisional diagnosed ABC.…”

Section: Discussionmentioning

confidence: 99%

“…Suggesting that theoretically, area of true invasive carcinoma may not represent in all tumor area or generally admixed with ABC component, but can produce a distinct infiltrate through the deep part of stroma [1,12] and that resulted in possibility of inadequate assessment by an excisional biopsy. The endocervical resection margin which markedly positive mostly by ABC indicated that we could not exclude a hiding admixed ACC or a further invasive SCC accompanied in the remaining cervix and a repeat conization would be recommended [21].…”

Section: Discussionmentioning

confidence: 99%

“…As the ABC rarely showed malignant behavior, the prognosis appears to depend on the associated malignancy component which also decides the treatment protocol [12]. Although the association of ABC with other malignancies has been reported from time to time, there is paucity of data regarding the specific clinical course, the appropriate diagnostic procedure and the recommended treatment approach.…”

Section: Introductionmentioning

confidence: 99%

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Cervical adenoid basal carcinoma associated with invasive squamous cell carcinoma: A report of rare co-existence and review of literature

et al. 2011

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Cervical adenoid basal carcinoma (ABC) rarely can harbor associated malignancies like adenoid cystic carcinoma or squamous cell carcinoma (SCC), which express markedly different prognosis from a pure ABC, making an appropriate biopsy essential to provide a clear diagnosis and therapeutic plan. We report a 64-year-old asymptomatic lady with an abnormal cervical cytology, who underwent a conization to reveal an ABC with overlying microinvasive SCC. Doubtful resection margins led us to perform radical hysterectomy with lymph node dissection. Subsequent pathological examination showed a true invasive SCC co-existing with ABC, with invasion of the parametrium. Unlike the indolent course of many pure ABC patients, the prognosis of 11 previously reported co-existing invasive SCC with ABC patients appears to depend on the SCC component. Our case reiterates the importance of adequate biopsy with careful interpretation to cover the possibility of a co-existent malignancy. Besides, it presents an argument in favor of radical surgery for the primary treatment of suspicious associated malignancy, and supports adjuvant treatment according to the unfavorable extent of the co-existent invasive carcinoma.

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Adenoid basal carcinoma combined with invasive squamous cell carcinoma of uterine cervix: A case report of a 37‐year‐old woman and literature review

Yüksel

Bektaş

Salman

2019

Diagnostic Cytopathology

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Adenoid basal carcinoma (ABC) is uncommon malignancy of the uterine cervix and it can be pure or combined with cervical intraepithelial lesions. There were less than 20 cases of ABC combined with invasive squamous carcinoma (mixed type) in English literature. These cases had similar properties as seen at postmenopausal women and diagnosed with abnormal cervical smear findings. Here we present a case of 37‐year‐old woman who suffered from spotting and received endocervical curettage. The pathological report revealed squamous cell carcinoma (SCC) of the cervix. The patient underwent type 3 radical hysterectomy and bilateral pelvic and para‐aortic lymph node dissection. The final pathological report revealed SCC coexisting with ABC. Human papillomavirus (HPV) 16,18 and others (11 types) were negative in both components of the mixed tumor by in situ hybridization detection. Our case was cytokeratin 7 negative, cytokeratin 8 positive and p63 positive which supports the hypothesis that mixed type cervical carcinoma originates from endocervical reserve cells.

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Cervical adenoid basal tumors comprised of adenoid basal epithelioma associated with various types of invasive carcinoma: Clinicopathologic features, human papillomavirus DNA detection, and P16 expression

Cited by 55 publications

References 19 publications

Human Papillomavirus–related Carcinoma With Adenoid Cystic–like Features

Human Papillomavirus–related Carcinoma With Adenoid Cystic–like Features

Cervical adenoid basal carcinoma associated with invasive squamous cell carcinoma: A report of rare co-existence and review of literature

Adenoid basal carcinoma combined with invasive squamous cell carcinoma of uterine cervix: A case report of a 37‐year‐old woman and literature review

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