Ceruminous adenocarcinoma: An analysis of the Surveillance Epidemiology and End Results (SEER) database

Ruhl, Douglas S.; Tolisano, Anthony M.; Swiss, Tyler P.; Littlefield, Philip D.; Golden, J. Blake

doi:10.1016/j.amjoto.2015.11.005

Cited by 7 publications

(10 citation statements)

References 8 publications

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“…The average age at presentation for carcinomas is about a decade earlier compared to ceruminous adenomas. In addition, age greater than 60 years at diagnosis may be associated with decreased survival [41]. The tumors most commonly arose from the posterosuperior quadrant of the lateral EAC [2].…”

Section: Malignant Ceruminous Neoplasmsmentioning

confidence: 99%

“…Adjuvant radiation therapy is indicated for large tumors, high-grade carcinomas and for recurrent tumors [2,8,53]. Analysis of SEER database revealed that patients that underwent radiation therapy had decreased survival compared to those that did not [41]. This is likely a reflection of the advanced tumor stage and aggressive nature of these carcinomas.…”

Section: Outcome and Managementmentioning

confidence: 99%

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Ceruminous Neoplasms of the Ear

Nagarajan

2018

Head and Neck Pathol

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Ceruminous glands are modified apocrine glands located in the external auditory canal (EAC). Neoplastic lesions arising from these glands are rare in humans and constitute a major differential diagnosis for glandular neoplasms of the EAC. Due to anatomic restrictions, benign and malignant neoplasms present with similar symptoms and to some extent even comparable radiologic features, particularly when the tumors are localized. Biopsies are frequently limited by small size, fragmentation and improper anatomic and architectural orientation, thereby hampering our ability to appreciate the relationship of peripheral edges of the tumor to the surrounding tissue. Benign and malignant tumors may also have overlapping histomorphologic features, which further magnifies the challenges in accurate diagnosis and management strategies. This article summarizes the salient clinical, radiologic and histologic features of common ceruminous gland tumors, in addition to discussing features that can aid in differentiating ceruminous tumors from other EAC tumors and to distinguish benign from malignant entities.

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Section: Malignant Ceruminous Neoplasmsmentioning

confidence: 99%

Section: Outcome and Managementmentioning

confidence: 99%

Ceruminous Neoplasms of the Ear

Nagarajan

2018

Head and Neck Pathol

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“…In some cases, the lesions are multiple and seen in various loci in external ear and scalp as a part of so-called turban tumour [1,2]. A primary malignant tumour of such localization is a ceruminous adenocarcinoma accounting less than 2.5% of tumours of external auditory meatus, which is characterized by a t(6:9) chromosomal translocation, resulting in MYB-NFIB gene fusion [22]. The aural polyp in the external acoustic meatus could be visible in young children [23,24].…”

Section: Primary and Secondary Tumoursmentioning

confidence: 99%

Benign and Malignant Tumours of the Ear and Temporal Bone

Burdan¹

2018

Imaging of the Temporomandibular Joint

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Neoplasms of the temporal bone, especially malignant ones, are rare. Their occurrence is estimated on 0.2% of all tumours of the head and neck, including lesions of the skin of the pinna that spread to the temporal bone, primary tumours of the external auditory meatus, middle ear and various parts to the temporal bone. Among benign neoplasms, the most common are adenoma, chordoma, lipoma, neurofibroma and schwannoma. Malignancies are usually represented by acinic cell carcinoma, adenocarcinoma, adenoid cystic carcinoma, basal cell carcinoma, squamous cell carcinoma, chondrosarcoma, osteosarcoma, haemato-lymphoid tumours (including lymphomas), rhabdomyosarcoma, melanoma, malignant neuroma and paraganglioma as well as metastatic lesions and infiltration by pharyngeal, parotid and CNS tumours [1,2]. The lymphatic drainage is typically exclusive for structures of external and middle ear (membranes labyrinth does not have lymph vessels), and their primary lymph nodes are retroauricular, paraauricular and upper deep cervical ones (radiological group II) that drain the lymph from both previous groups. Lymph from the auditory tube is also drained into retropharyngeal nodes but finally is collected by deep cervical ones-group II and III [3][4][5].

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“…As locally invasive lesions, they can induce aural atresia and nerve paralysis as they progress. Although complete surgical resection is sufficient in most cases, some cases have reported disappointing outcomes 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

“…Based on their patterns of growth and cell types, ceruminous adenocarcinomas have been subclassified as adenocarcinoma (not otherwise specified, NOS), adenoid cystic carcinoma and mucoepidermoid carcinoma 6 . Fewer than 30 cases of human ceruminous adenocarcinoma (NOS) have been reported in the English literature 1 , 4 . The histological features of adenoid cystic carcinoma and mucoepidermoid carcinoma are identical to those of normal salivary gland cells 7 .…”

Section: Introductionmentioning

confidence: 99%